Complex genetics of complex traits: the case of primary open‐angle glaucoma
10.1111/j.1442-9071.2006.01268.x
Crossref journal-article
Wiley
Clinical & Experimental Ophthalmology (311)
Abstract

AbstractGlaucoma, which is a complex heterogeneous disease, presents an ideal case for genetic investigation. Primary open‐angle glaucoma (POAG) is the commonest subtype and will be the focus of this review. When detected early, POAG is amenable to therapeutic intervention. Unfortunately, current population‐based clinical screening lacks efficacy. If individuals with a genetic predisposition for developing POAG can be identified, then efficient and cost‐effective population‐based screening programs could be designed. Although considerable inroads have been made in understanding the natural history of POAG caused by mutations in the myocilin and optineurin genes, other POAG genes accounting for most cases remain to be identified. This review explores the genetic mechanisms that have been unequivocally linked to the glaucomatous process and then discusses potential avenues for future breakthroughs.

Bibliography

Hewitt, A. W., Craig, J. E., & Mackey, D. A. (2006). Complex genetics of complex traits: the case of primary open‐angle glaucoma. Clinical & Experimental Ophthalmology, 34(5), 472–484. Portico.

Authors 3
  1. Alex W Hewitt (first)
  2. Jamie E Craig (additional)
  3. David A Mackey (additional)
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Dates
Type When
Created 19 years, 1 month ago (July 12, 2006, 5:08 a.m.)
Deposited 1 year, 10 months ago (Oct. 10, 2023, 1:23 a.m.)
Indexed 9 months, 2 weeks ago (Nov. 19, 2024, 11 a.m.)
Issued 19 years, 2 months ago (July 1, 2006)
Published 19 years, 2 months ago (July 1, 2006)
Published Online 19 years, 1 month ago (July 12, 2006)
Published Print 19 years, 2 months ago (July 1, 2006)
Funders 0

None

@article{Hewitt_2006, title={Complex genetics of complex traits: the case of primary open‐angle glaucoma}, volume={34}, ISSN={1442-9071}, url={http://dx.doi.org/10.1111/j.1442-9071.2006.01268.x}, DOI={10.1111/j.1442-9071.2006.01268.x}, number={5}, journal={Clinical &amp; Experimental Ophthalmology}, publisher={Wiley}, author={Hewitt, Alex W and Craig, Jamie E and Mackey, David A}, year={2006}, month=jul, pages={472–484} }