DOI: 10.1111/j.1440-1827.1994.tb02582.x. Anatomical distribution of HTLV‐I proviral sequence in an autopsy case of HTLV‐I associated myelopathy: A polymerase chain reaction study

Anatomical distribution of HTLV‐I proviral sequence in an autopsy case of HTLV‐I associated myelopathy: A polymerase chain reaction study

10.1111/j.1440-1827.1994.tb02582.x

Crossref journal-article

Wiley

Pathology International (311)

Abstract

HTLV‐I associated myelopathy (HAM) is a slowly progressive paraplegia of the lower extremities observed among HTLV‐I carriers. An autopsy of a typical HAM case in which perivascular lymphocytic infiltration was not limited to the central nervous system was examined. Spinal dorsal roots, salivary gland, lungs, liver and kidney showed non‐specific, but unusual sporadic perivascular lymphocytic infiltration, which resembled the findings in the spinal cord. To investigate the anatomical distribution of HTLV‐I provirus, the HTLV‐I proviral sequences, tax and pol, were amplified from the formalin‐fixed paraffin‐embedded tissues of the autopsy case using polymerase chain reaction (PCR). By PCR, strong HTLV‐I provirus signals were detected in the spinal cord, peripheral nerve, muscle, lungs and liver. Weak signals were detected in the medulla oblongata, optic nerve and lymph node, while the other organs, including the cerebrum, were negative. The data from this study show the specific distribution of HTLV‐I provirus in the distinct organs of a HAM patient.

Bibliography

Sueyoshi, K., Goto, M., Johnosono, M., Sato, E., & Shibata, D. (1994). Anatomical distribution of HTLVâI proviral sequence in an autopsy case of HTLVâI associated myelopathy: A polymerase chain reaction study. Pathology International, 44(1), 27â33. Portico.

Authors 5

Kazunobu Sueyoshi (first)
Masamichi Goto (additional)
Manabu Johnosono (additional)
Eiichi Sato (additional)
Darryl Shibata (additional)

References 33 Referenced 9

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Dates

Type	When
Created	16 years, 8 months ago (Dec. 11, 2008, 2:49 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 8:35 a.m.)
Indexed	5 months, 1 week ago (March 27, 2025, 11:54 a.m.)
Issued	31 years, 8 months ago (Jan. 1, 1994)
Published	31 years, 8 months ago (Jan. 1, 1994)
Published Online	16 years, 8 months ago (Dec. 11, 2008)
Published Print	31 years, 8 months ago (Jan. 1, 1994)

Funders 0

None

BibTeX

@article{Sueyoshi_1994, title={Anatomical distribution of HTLV‐I proviral sequence in an autopsy case of HTLV‐I associated myelopathy: A polymerase chain reaction study}, volume={44}, ISSN={1440-1827}, url={http://dx.doi.org/10.1111/j.1440-1827.1994.tb02582.x}, DOI={10.1111/j.1440-1827.1994.tb02582.x}, number={1}, journal={Pathology International}, publisher={Wiley}, author={Sueyoshi, Kazunobu and Goto, Masamichi and Johnosono, Manabu and Sato, Eiichi and Shibata, Darryl}, year={1994}, month=jan, pages={27–33} }

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