DOI: 10.1111/j.1440-1681.1994.tb02484.x. EFFECT OF TRANSFORMING GROWTH FACTOR‐β1 ON PLATELET‐DERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS

EFFECT OF TRANSFORMING GROWTH FACTOR‐β1 ON PLATELET‐DERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS

10.1111/j.1440-1681.1994.tb02484.x

Crossref journal-article

Wiley

Clinical and Experimental Pharmacology and Physiology (311)

Abstract

SUMMARY1. This study examined the effects of transforming growth factor‐βl (TGF‐β1) on platelet‐derived growth factor‐BB (PDGF‐BB)‐stimulated DNA synthesis, [125I]‐PDGF‐BB receptor binding and PDGF‐β receptor mRNA expression in vascular smooth muscle cells (VSMC) isolated from Wistar‐Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).2. TGF‐β1 inhibited by 40% DNA synthesis stimulated by PDGF‐BB in VSMC from WKY rats but potentiated by 20% growth factor‐stimulated DNA synthesis in VSMC from the SHR.3. Since the difference in effect of TGF‐β1 could not be attributed to differential regulation of [125I]‐PDGF‐BB binding activity and PDGF‐β receptor mRNA expression, it is suggested that alterations in intracellular signalling pathways may account for the differential effects of TGF‐β1 on PDGF‐BB‐stimulated DNA synthesis in VSMC from SHR and WKY rats.

Bibliography

Agrotis, A., Saltis, J., & Bobik, A. (1994). EFFECT OF TRANSFORMING GROWTH FACTORâÎ²1 ON PLATELETâDERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS. Clinical and Experimental Pharmacology and Physiology, 21(2), 145â148. Portico.

Authors 3

Alex Agrotis (first)
John Saltis (additional)
Alex Bobik (additional)

References 14 Referenced 10

Dates

Type	When
Created	18 years, 2 months ago (June 29, 2007, 2:05 a.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, noon)
Indexed	2 months, 2 weeks ago (June 11, 2025, 5:29 a.m.)
Issued	31 years, 6 months ago (Feb. 1, 1994)
Published	31 years, 6 months ago (Feb. 1, 1994)
Published Online	18 years, 2 months ago (June 28, 2007)
Published Print	31 years, 6 months ago (Feb. 1, 1994)

Funders 0

None

BibTeX

@article{Agrotis_1994, title={EFFECT OF TRANSFORMING GROWTH FACTOR‐β1 ON PLATELET‐DERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS}, volume={21}, ISSN={1440-1681}, url={http://dx.doi.org/10.1111/j.1440-1681.1994.tb02484.x}, DOI={10.1111/j.1440-1681.1994.tb02484.x}, number={2}, journal={Clinical and Experimental Pharmacology and Physiology}, publisher={Wiley}, author={Agrotis, Alex and Saltis, John and Bobik, Alex}, year={1994}, month=feb, pages={145–148} }

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