DOI: 10.1111/j.1432-1033.1996.0712p.x. Selection <i>in vitro</i> of <i>Trans</i> ‐Acting Genomic Human Hepatitis Delta Virus (HDV) Ribozymes

Selection in vitro of Trans ‐Acting Genomic Human Hepatitis Delta Virus (HDV) Ribozymes

10.1111/j.1432-1033.1996.0712p.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

In an effort to identify the functional structure as well as new active variants of the trans‐ acting genomic ribozyme of human hepatitis delta virus (HDV), we applied an in vitro selection procedure. A total of 14 rounds of selection and amplification was repeated and various mutant ribozymes in G10 and G14 pools analyzed. Active ribozymes which were isolated in the present study (from G10 and G14) all possessed conserved bases (that were identified earlier) in the m‐acting molecule. A dominant clone G10‐68 variant was accumulated in generation 14. Interestingly, when base substitutions were analyzed in G10‐68 variant, we found that this variant appears to be close to antigenome‐like HDV ribozyme molecule. Further investigations of G10‐68 confirmed that each mutated base was the most appropriate nucleotide at every position of the HDV ribozyme.

Bibliography

Nishikawa, F., Kawakami, J., Chiba, A., Shirai, M., Kumar, P. K. R., & Nishikawa, S. (1996). Selection in vitro of Trans âActing Genomic Human Hepatitis Delta Virus (HDV) Ribozymes. European Journal of Biochemistry, 237(3), 712â718. Portico.

Authors 6

Fumiko Nishikawa (first)
Junji Kawakami (additional)
Atsushi Chiba (additional)
Makoto Shirai (additional)
Penmetcha K. R. Kumar (additional)
Satoshi Nishikawa (additional)

References 31 Referenced 15

10.1016/S0016-5085(84)80153-5 / Gasteroenterology by Govindarajan S. (1984)
10.1128/JVI.62.12.4439-4444.1988
10.1128/JVI.62.8.2674-2679.1988
10.1021/bi00155a015
10.1038/350434a0
10.1093/nar/19.19.5409
10.1073/pnas.88.22.10163
10.1016/0022-2836(92)90728-3
10.1093/nar/20.4.747
10.1093/nar/20.15.3919
10.1096/fasebj.7.1.8422958
10.1016/0014-5793(93)81782-U
10.1111/j.1432-1033.1993.tb18214.x
10.1021/bi00168a025
10.1016/S0960-9822(00)00109-3
10.1093/nar/22.18.3722
10.1021/bi00162a024
10.1093/nar/21.18.4253
10.1101/gad.6.1.129
10.1021/bi00131a001
10.1126/science.1496376
10.1038/358560a0
10.1038/361182a0
10.1101/gad.7.1.130
10.1021/bi00185a038
10.1006/bbrc.1995.2301
{'key': 'e_1_2_3_28_2', 'first-page': '11', 'volume': '1', 'author': 'Leung D. W.', 'year': '1989', 'journal-title': 'Technique'} / Technique by Leung D. W. (1989)
10.1093/nar/21.17.3959
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10.1021/bi00116a004

Dates

Type	When
Created	20 years, 11 months ago (Aug. 31, 2004, 10:14 a.m.)
Deposited	1 year, 9 months ago (Oct. 31, 2023, 7:15 a.m.)
Indexed	1 year, 9 months ago (Nov. 1, 2023, 3:35 a.m.)
Issued	29 years, 3 months ago (May 1, 1996)
Published	29 years, 3 months ago (May 1, 1996)
Published Online	20 years, 11 months ago (Aug. 31, 2004)
Published Print	29 years, 3 months ago (May 1, 1996)

Funders 0

None

BibTeX

@article{Nishikawa_1996, title={Selection in vitro of Trans ‐Acting Genomic Human Hepatitis Delta Virus (HDV) Ribozymes}, volume={237}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1996.0712p.x}, DOI={10.1111/j.1432-1033.1996.0712p.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={Nishikawa, Fumiko and Kawakami, Junji and Chiba, Atsushi and Shirai, Makoto and Kumar, Penmetcha K. R. and Nishikawa, Satoshi}, year={1996}, month=may, pages={712–718} }

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