DOI: 10.1111/j.1432-1033.1995.1096g.x. A Human Homologue of the Yeast Replication Protein Cdc21

A Human Homologue of the Yeast Replication Protein Cdc21

10.1111/j.1432-1033.1995.1096g.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

We present the amino acid sequence of the human homologue of the yeast replication protein Cdc21, a member of the Mcm family of nuclear proteins. Specific antibodies, raised against protein hCdc21, were used to investigate the expression of the protein through the cell cycle. The protein is highly phosphorylated in mitotic cells. The phosphorylated form of protein hCdc21 appears to be less tightly bound to nuclear structures than the underphosphorylated form suggesting that phosphorylation/dephosphorylation reactions may determine the nuclear distribution of the protein. Protein hCdc21 forms a stable trimeric complex with two novel human Mcm proteins, p85Mcm and p105Mcm. Protein BM28/Mcm2 is more loosely associated with the trimeric hCdc21 complex.

Bibliography

Musahl, C., Schulte, D., Burkhart, R., & Knippers, R. (1995). A Human Homologue of the Yeast Replication Protein Cdc21. European Journal of Biochemistry, 230(3), 1096â1101. Portico.

Authors 4

Christine Musahl (first)
Dorothea Schulte (additional)
Roland Burkhart (additional)
Rolf Knippers (additional)

References 24 Referenced 11

10.1016/0076-6879(92)19013-V
10.1111/j.1432-1033.1995.0431n.x
10.1002/yea.320090714
10.1093/nar/20.21.5571
10.1242/jcs.107.10.2779 / J. Cell Sci. / The fission yeast cdc19 + gene encodes a member of the MCM family of replication proteins by Forsburg S. L. (1994)
10.1128/MCB.10.11.5707
{'key': 'e_1_2_2_8_1', 'volume-title': 'Antibodies, A. laboratory handbook', 'author': 'Harlow E.', 'year': '1988'} / Antibodies, A. laboratory handbook by Harlow E. (1988)
10.1093/nar/21.23.5289-a
10.1016/0968-0004(90)90073-K
10.1002/j.1460-2075.1994.tb06751.x
10.1083/jcb.115.4.887
10.1111/j.1462-5822.2007.00901.x
10.1159/000133918
10.1007/BF00422777
10.1016/0962-8924(93)90011-O
10.1016/0092-8674(91)90245-T
{'key': 'e_1_2_2_18_1', 'volume-title': 'Molecular cloning: a laboratory manual', 'author': 'Sambrook J. E. E.', 'year': '1989'} / Molecular cloning: a laboratory manual by Sambrook J. E. E. (1989)
10.1242/jcs.108.4.1381 / J. Cell Sci. / Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein by Schulte D. (1995)
10.1242/jcs.107.1.253 / J. Cell Sci. / A human nuclear protein with sequence homology to a family of early S phase proteins is required for the entry into S phase and for cell division by Todorov I. T. (1994)
10.1073/pnas.76.9.4350
10.1016/S0968-0004(00)88960-4
10.1016/0962-8924(94)90200-3
10.1101/gad.5.6.944
10.1101/gad.7.11.2149

Dates

Type	When
Created	15 years, 1 month ago (July 21, 2010, 1:29 p.m.)
Deposited	1 year, 9 months ago (Nov. 23, 2023, 9:08 a.m.)
Indexed	1 year, 7 months ago (Jan. 2, 2024, 5:23 a.m.)
Issued	30 years, 3 months ago (June 1, 1995)
Published	30 years, 3 months ago (June 1, 1995)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	30 years, 3 months ago (June 1, 1995)

Funders 0

None

BibTeX

@article{Musahl_1995, title={A Human Homologue of the Yeast Replication Protein Cdc21: Interactions with Other Mcm Proteins}, volume={230}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1995.1096g.x}, DOI={10.1111/j.1432-1033.1995.1096g.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={Musahl, Christine and Schulte, Dorothea and Burkhart, Roland and Knippers, Rolf}, year={1995}, month=jun, pages={1096–1101} }

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