DOI: 10.1111/j.1432-1033.1993.tb18151.x. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to <i>Drosophila</i> enhancer of split groucho protein

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein

10.1111/j.1432-1033.1993.tb18151.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

Mouse and human cDNA encoding AES (amino‐terminal enhancer of split) and ESG (enhancer of split groucho) proteins with strong similarity to Drosophila enhancer of split groucho protein were isolated and sequenced. Mouse AES‐1 and AES‐2 proteins, probably resulting from alternative splicing, contain 202 and 196 amino acids, respectively, while mouse ESG protein consists of 771 amino acids. The amino acid sequences of mouse and human AES proteins were found to exhibit approximately 50% identity to the amino‐terminal region of Drosophila groucho, mouse ESG and human transducin‐like enhancer of split (TLE) proteins. Mouse AES transcripts of 1.5 kb and 1.2 kb were abundantly expressed in muscle, heart and brain. Human AES transcripts of 1.6 kb and 1.4 kb were predominantly present in muscle, heart and placenta. Mouse ESG (homolog of human TLE 3) transcripts of 3.3 kb and 4.0 kb were found only in testis, while human TLE 1 transcripts of 4.5 kb was more abundant in muscle and placenta compared to heart, brain, lung, liver, kidney and pancreas. Human AES, TLE 1 and TLE 3 genes were mapped to chromosomes 19, 9 and 15, respectively, using human and Chinese hamster hybrid cell lines.

Bibliography

MIYASAKA, H., CHOUDHURY, B. K., HOU, E. W., & LI, S. S. âL. (1993). Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. European Journal of Biochemistry, 216(1), 343â352. Portico.

Authors 4

Hitoshi MIYASAKA (first)
Barun K. CHOUDHURY (additional)
Esther W. HOU (additional)
Steven S.‐L. LI (additional)

References 20 Referenced 58

10.1146/annurev.ne.14.030191.002151
10.1016/0092-8674(88)90134-1
10.1073/pnas.83.7.2162
10.1038/ng1092-119
10.1095/biolreprod46.5.869
10.1073/pnas.87.4.1501
{'key': 'e_1_2_2_8_2', 'volume-title': 'Molecular Cloning: a laboratory manual', 'author': 'Sambrook J.', 'year': '1989'} / Molecular Cloning: a laboratory manual by Sambrook J. (1989)
10.1073/pnas.80.13.3963
10.1093/nar/12.1Part1.387
10.1016/0006-291X(92)91700-Z
10.1126/science.2047873
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10.1016/0022-2836(87)90646-2
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10.1016/0378-1119(91)90047-F
10.1126/science.3289117
10.1038/336646a0
10.1016/0092-8674(92)90145-3

Dates

Type	When
Created	20 years, 5 months ago (March 4, 2005, 3:50 a.m.)
Deposited	1 year, 9 months ago (Nov. 22, 2023, 10:17 p.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 9:50 a.m.)
Issued	32 years ago (Aug. 1, 1993)
Published	32 years ago (Aug. 1, 1993)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	32 years ago (Aug. 1, 1993)

Funders 0

None

BibTeX

@article{MIYASAKA_1993, title={Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein}, volume={216}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1993.tb18151.x}, DOI={10.1111/j.1432-1033.1993.tb18151.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={MIYASAKA, Hitoshi and CHOUDHURY, Barun K. and HOU, Esther W. and LI, Steven S.‐L.}, year={1993}, month=aug, pages={343–352} }

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