DOI: 10.1111/j.1432-1033.1992.tb17422.x. Characterization of a nitric‐oxide‐catalysed ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase

Characterization of a nitric‐oxide‐catalysed ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase

10.1111/j.1432-1033.1992.tb17422.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

Auto‐ADP‐ribosylation of the glycolytic enzyme glyceraldehyde‐3‐phosphate dehydrogenase (GraPDH) has recently been demonstrated to be dramatically stimulated in the presence of nitric oxide. In order to obtain insight into the sequence of events leading to ADP‐ribosylation of GraPDH, we studied the target amino acid, the nucleotide cofactor requirement, pH dependency and the stoichiometry of the reaction. Basal as well as stimulated ADP‐ribose transfer is inhibited by the SH‐group alkylating reagent, N‐ethylmaleimide. Furthermore, the radiolabel of auto‐[32P]ADP‐ribosylated GraPDH is removed by treatment with HgCl2, suggesting an ADP‐ribose–cysteine bond. Several indirect and direct mechanistic considerations point to NAD+ as the only cofactor for the ADP‐ribosylation reaction, excluding the possibility of a reaction sequence involving a NAD‐glycohydrolase(s) followed by nonenzymatic ADP‐ribose transfer to GraPDH. Optimal ADP‐ribosylations were carried out at alkaline pH values using 10 μM free NAD+ as the sole nucleotide cofactor. Bovine serum albumin with an S‐nitrosylated SH group can serve as a model of ADP‐ribose transfer from NAD+ and suggests that the nitric‐oxide‐modified SH group (S‐nitrosylated SH group) is a prerequisite for the reaction.

Bibliography

DIMMELER, S., & BRÃNE, B. (1992). Characterization of a nitricâoxideâcatalysed ADPâribosylation of glyceraldehydeâ3âphosphate dehydrogenase. European Journal of Biochemistry, 210(1), 305â310. Portico.

Authors 2

Stefanie DIMMELER (first)
Bernhard BRÜNE (additional)

References 45 Referenced 47

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Dates

Type	When
Created	20 years, 5 months ago (March 4, 2005, 2:36 a.m.)
Deposited	1 year, 9 months ago (Oct. 30, 2023, 11:38 p.m.)
Indexed	1 year, 1 month ago (July 6, 2024, 10:34 a.m.)
Issued	32 years, 9 months ago (Nov. 1, 1992)
Published	32 years, 9 months ago (Nov. 1, 1992)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	32 years, 9 months ago (Nov. 1, 1992)

Funders 0

None

BibTeX

@article{DIMMELER_1992, title={Characterization of a nitric‐oxide‐catalysed ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase}, volume={210}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1992.tb17422.x}, DOI={10.1111/j.1432-1033.1992.tb17422.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={DIMMELER, Stefanie and BRÜNE, Bernhard}, year={1992}, month=nov, pages={305–310} }

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