DOI: 10.1111/j.1432-1033.1991.tb16003.x. Comparison of multiple forms of the high mobility group I proteins in rodent and human cells

Comparison of multiple forms of the high mobility group I proteins in rodent and human cells

10.1111/j.1432-1033.1991.tb16003.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

The class I of the high mobility group (HMG) proteins is formed by phosphoproteins which are associated with AT‐rich DNA sequences in the nucleus. Three HMGI proteins have previously been described in proliferating rodent cells (HMG Y, HMG I and HMGI‐C). All three proteins exhibit microheterogeneity. The microheterogeneity of mouse HMG Y has been investigated in detail and shown to be due to phosphorylation of the protein which is sensitive to alkaline‐phosphatase treatment. HMG I is similarly modified. Human cells have up to now only been found to contain HMG Y and HMG I. A search for the third protein, HMGI‐C, in human cells was carried out and the protein was found in a hepatoma cell line, but not in normal or transformed T‐cells. This HMGI‐C protein was found to be modified by phosphorylation, part of which was found to be phosphatase insensitive. An unexpected additional finding in this study was that human cells contain two HMG17 proteins which differ in their N‐terminal primary sequences.

Bibliography

GIANCOTTI, V., BANDIERA, A., BURATTI, E., FUSCO, A., MARZARI, R., COLES, B., & GOODWIN, G. H. (1991). Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. European Journal of Biochemistry, 198(1), 211â216. Portico.

Authors 7

Vincenzo GIANCOTTI (first)
Antonella BANDIERA (additional)
Emanuele BURATTI (additional)
Alfredo FUSCO (additional)
Roberto MARZARI (additional)
Brian COLES (additional)
Graham H. GOODWIN (additional)

References 27 Referenced 46

{'key': 'e_1_2_3_2_2', 'volume-title': 'The HMG chromosomal proteins', 'author': 'Johns E. W.', 'year': '1982'} / The HMG chromosomal proteins by Johns E. W. (1982)
{'key': 'e_1_2_3_3_2', 'first-page': '187', 'volume-title': 'Architecture of eukaryotic genes', 'author': 'Goodwin G.', 'year': '1988'} / Architecture of eukaryotic genes by Goodwin G. (1988)
10.1038/344830a0
10.1016/0014-5793(83)80370-6
10.1016/0014-5793(85)81085-1
10.1016/0092-8674(84)90424-0
10.1016/S0021-9258(19)81364-9
10.1128/MCB.9.5.2114
{'key': 'e_1_2_3_10_2', 'first-page': '6051', 'volume': '45', 'author': 'Giancotti V.', 'year': '1985', 'journal-title': 'Cancer Res.'} / Cancer Res. by Giancotti V. (1985)
10.1002/j.1460-2075.1987.tb02461.x
10.1111/j.1432-1033.1985.tb08891.x
10.1016/0014-4827(89)90352-2
10.1073/pnas.83.5.1276
10.1093/nar/17.23.9909
10.1093/nar/17.15.5947
10.1128/MCB.8.8.3406
10.1016/S0021-9258(18)83195-7 / J. Biol. Chem. by Ashley C. T. (1989)
10.1038/335683a0
10.1016/0165-022X(86)90062-X
10.1111/j.1432-1033.1987.tb13477.x
10.1016/0006-291X(90)91399-D
10.1016/0006-291X(87)90589-4
10.1016/0014-5793(89)81796-X
10.1111/j.1432-1033.1977.tb11616.x
10.1016/S0021-9258(17)38417-X / J. Biol. Chem. by Landsman D. (1986)
10.1038/344517a0
10.1083/jcb.109.5.1975

Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 11:56 p.m.)
Deposited	1 year, 9 months ago (Oct. 31, 2023, 6:11 a.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:45 a.m.)
Issued	34 years, 3 months ago (May 1, 1991)
Published	34 years, 3 months ago (May 1, 1991)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	34 years, 3 months ago (May 1, 1991)

Funders 0

None

BibTeX

@article{GIANCOTTI_1991, title={Comparison of multiple forms of the high mobility group I proteins in rodent and human cells: Identification of the human high mobility group I‐C protein}, volume={198}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1991.tb16003.x}, DOI={10.1111/j.1432-1033.1991.tb16003.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={GIANCOTTI, Vincenzo and BANDIERA, Antonella and BURATTI, Emanuele and FUSCO, Alfredo and MARZARI, Roberto and COLES, Brian and GOODWIN, Graham H.}, year={1991}, month=may, pages={211–216} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        11
      ]
    ],
    "date-time": "2025-07-11T10:45:23Z",
    "timestamp": 1752230723631
  },
  "reference-count": 27,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            3,
            3
          ]
        ],
        "date-time": "2005-03-03T00:00:00Z",
        "timestamp": 1109808000000
      },
      "content-version": "vor",
      "delay-in-days": 5055,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1991,
        5
      ]
    ]
  },
  "abstract": "<jats:p>The class I of the high mobility group (HMG) proteins is formed by phosphoproteins which are associated with AT\u2010rich DNA sequences in the nucleus. Three HMGI proteins have previously been described in proliferating rodent cells (HMG Y, HMG I and HMGI\u2010C). All three proteins exhibit microheterogeneity. The microheterogeneity of mouse HMG Y has been investigated in detail and shown to be due to phosphorylation of the protein which is sensitive to alkaline\u2010phosphatase treatment. HMG I is similarly modified. Human cells have up to now only been found to contain HMG Y and HMG I. A search for the third protein, HMGI\u2010C, in human cells was carried out and the protein was found in a hepatoma cell line, but not in normal or transformed T\u2010cells. This HMGI\u2010C protein was found to be modified by phosphorylation, part of which was found to be phosphatase insensitive. An unexpected additional finding in this study was that human cells contain two HMG17 proteins which differ in their N\u2010terminal primary sequences.</jats:p>",
  "DOI": "10.1111/j.1432-1033.1991.tb16003.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        3,
        4
      ]
    ],
    "date-time": "2005-03-04T04:56:45Z",
    "timestamp": 1109912205000
  },
  "page": "211-216",
  "source": "Crossref",
  "is-referenced-by-count": 46,
  "title": "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells",
  "prefix": "10.1111",
  "volume": "198",
  "author": [
    {
      "given": "Vincenzo",
      "family": "GIANCOTTI",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Antonella",
      "family": "BANDIERA",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Emanuele",
      "family": "BURATTI",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alfredo",
      "family": "FUSCO",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Roberto",
      "family": "MARZARI",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Brian",
      "family": "COLES",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Graham H.",
      "family": "GOODWIN",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2005,
        3,
        3
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_3_2_2",
      "volume-title": "The HMG chromosomal proteins",
      "author": "Johns E. W.",
      "year": "1982"
    },
    {
      "key": "e_1_2_3_3_2",
      "first-page": "187",
      "volume-title": "Architecture of eukaryotic genes",
      "author": "Goodwin G.",
      "year": "1988"
    },
    {
      "key": "e_1_2_3_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/344830a0"
    },
    {
      "key": "e_1_2_3_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(83)80370-6"
    },
    {
      "key": "e_1_2_3_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(85)81085-1"
    },
    {
      "key": "e_1_2_3_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(84)90424-0"
    },
    {
      "key": "e_1_2_3_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)81364-9"
    },
    {
      "key": "e_1_2_3_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.9.5.2114"
    },
    {
      "key": "e_1_2_3_10_2",
      "first-page": "6051",
      "volume": "45",
      "author": "Giancotti V.",
      "year": "1985",
      "journal-title": "Cancer Res."
    },
    {
      "key": "e_1_2_3_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1987.tb02461.x"
    },
    {
      "key": "e_1_2_3_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1985.tb08891.x"
    },
    {
      "key": "e_1_2_3_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4827(89)90352-2"
    },
    {
      "key": "e_1_2_3_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.83.5.1276"
    },
    {
      "key": "e_1_2_3_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/17.23.9909"
    },
    {
      "key": "e_1_2_3_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/17.15.5947"
    },
    {
      "key": "e_1_2_3_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.8.8.3406"
    },
    {
      "key": "e_1_2_3_18_2",
      "doi-asserted-by": "crossref",
      "first-page": "8394",
      "DOI": "10.1016/S0021-9258(18)83195-7",
      "volume": "264",
      "author": "Ashley C. T.",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "e_1_2_3_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/335683a0"
    },
    {
      "key": "e_1_2_3_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0165-022X(86)90062-X"
    },
    {
      "key": "e_1_2_3_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1987.tb13477.x"
    },
    {
      "key": "e_1_2_3_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-291X(90)91399-D"
    },
    {
      "key": "e_1_2_3_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-291X(87)90589-4"
    },
    {
      "key": "e_1_2_3_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(89)81796-X"
    },
    {
      "key": "e_1_2_3_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1977.tb11616.x"
    },
    {
      "key": "e_1_2_3_26_2",
      "doi-asserted-by": "crossref",
      "first-page": "7479",
      "DOI": "10.1016/S0021-9258(17)38417-X",
      "volume": "261",
      "author": "Landsman D.",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "e_1_2_3_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/344517a0"
    },
    {
      "key": "e_1_2_3_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.109.5.1975"
    }
  ],
  "container-title": "European Journal of Biochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1432-1033.1991.tb16003.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1991.tb16003.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        31
      ]
    ],
    "date-time": "2023-10-31T10:11:47Z",
    "timestamp": 1698747107000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1991.tb16003.x"
    }
  },
  "subtitle": [
    "Identification of the human high mobility group I\u2010C protein"
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1991,
        5
      ]
    ]
  },
  "references-count": 27,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1991,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1432-1033.1991.tb16003.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1432-1033.1991.tb16003.x",
  "relation": {},
  "ISSN": [
    "0014-2956",
    "1432-1033"
  ],
  "subject": [],
  "container-title-short": "European Journal of Biochemistry",
  "published": {
    "date-parts": [
      [
        1991,
        5
      ]
    ]
  }
}