DOI: 10.1111/j.1432-1033.1990.tb19280.x. The complete amino‐acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein

The complete amino‐acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein

10.1111/j.1432-1033.1990.tb19280.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

The complete amino‐acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein have been established by Edman degradation. The GM2 activator is composed of 162 amino acids, the first two serine residues being present in only 20% of the material. A single carbohydrate chain is N‐glycosidically linked to Asn32. Three hydrophobic α‐helices may contribute to its lipid‐binding site. Three amino acids differ from those found by cDNA sequencing which may be due to a polymorphism. The cerebroside sulfate activator consists of 80 amino acids and carries one N‐linked carbohydrate chain at Asn21. The C‐terminal valine residue is lacking in about 80% of the material. In spite their similar functions, both activator proteins show no sequence or structural similarities.

Bibliography

FÃRST, W., SCHUBERT, J., MACHLEIDT, W., MEYER, H. E., & SANDHOFF, K. (1990). The complete aminoâacid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein. European Journal of Biochemistry, 192(3), 709â714. Portico.

Authors 5

Werner FÜRST (first)
Jörg SCHUBERT (additional)
Werner MACHLEIDT (additional)
Helmut E. MEYER (additional)
Konrad SANDHOFF (additional)

References 29 Referenced 44

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{'key': 'e_1_2_3_21_2', 'first-page': '385', 'volume-title': 'Methods in protein sequence analysis', 'author': 'Machleidt W.', 'year': '1987'} / Methods in protein sequence analysis by Machleidt W. (1987)
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Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 11:22 p.m.)
Deposited	1 year, 10 months ago (Oct. 1, 2023, 10:31 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:25 a.m.)
Issued	34 years, 11 months ago (Sept. 1, 1990)
Published	34 years, 11 months ago (Sept. 1, 1990)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	34 years, 11 months ago (Sept. 1, 1990)

Funders 0

None

BibTeX

@article{F_RST_1990, title={The complete amino‐acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein}, volume={192}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1990.tb19280.x}, DOI={10.1111/j.1432-1033.1990.tb19280.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={FÜRST, Werner and SCHUBERT, Jörg and MACHLEIDT, Werner and MEYER, Helmut E. and SANDHOFF, Konrad}, year={1990}, month=sep, pages={709–714} }

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