DOI: 10.1111/j.1432-1033.1986.tb10501.x. Enhanced casein kinase II activity during mouse embryogenesis

Enhanced casein kinase II activity during mouse embryogenesis

10.1111/j.1432-1033.1986.tb10501.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

Mouse embryos at various stages of development were used to study the relationship of protein kinase activities with normal embryogenesis. Casein kinase II (CKII) activity in developing mouse embryos shows a 3–4‐fold activity increase at day 12 of gestation. Together with the CKII activity, increased phosphorylation of a 110‐kDa protein is observed. Treatment of the embryo extracts with heparin, a highly specific inhibitor of CKII activity, results in a drastic reduction of the 110‐kDa protein phosphorylation indicating that the protein might be a CKII‐specific substrate. Rapidly proliferating mouse tumour cells also show an enhanced CKII activity. Here too, a 110‐kDa phosphoprotein was the major phosphoryl acceptor. Partial proteolytic digestion shows that both proteins are identical. Other protein kinases tested (cAMP‐and cGMP‐dependent protein kinases) only show a basal level of enzyme activity with minor alterations throughout the different stages of embryogenesis investigated.

Bibliography

SCHNEIDER, H. R., REICHERT, G. H., & ISSINGER, O. (1986). Enhanced casein kinase II activity during mouse embryogenesis. European Journal of Biochemistry, 161(3), 733â738. Portico.

Authors 3

Helge R. SCHNEIDER (first)
Gerd H. REICHERT (additional)
Olaf‐Georg ISSINGER (additional)

References 35 Referenced 95

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Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 7:59 p.m.)
Deposited	1 year, 10 months ago (Oct. 7, 2023, 3:03 a.m.)
Indexed	3 weeks, 6 days ago (Aug. 5, 2025, 8:12 a.m.)
Issued	38 years, 9 months ago (Dec. 1, 1986)
Published	38 years, 9 months ago (Dec. 1, 1986)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	38 years, 9 months ago (Dec. 1, 1986)

Funders 0

None

BibTeX

@article{SCHNEIDER_1986, title={Enhanced casein kinase II activity during mouse embryogenesis: Identification of a 110‐kDa phosphoprotein as the major phosphorylation product in mouse embryos and Krebs II mouse ascites tumor cells}, volume={161}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1986.tb10501.x}, DOI={10.1111/j.1432-1033.1986.tb10501.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={SCHNEIDER, Helge R. and REICHERT, Gerd H. and ISSINGER, Olaf‐Georg}, year={1986}, month=dec, pages={733–738} }

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