DOI: 10.1111/j.1432-1033.1984.tb08435.x. Molecular cloning of hepatic 5‐aminolevulinate synthase

Molecular cloning of hepatic 5‐aminolevulinate synthase

10.1111/j.1432-1033.1984.tb08435.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

Hepatic 5‐aminolevulinate synthase was induced in chick embryos by administration of the porphyrinogenic drugs 2‐allyl‐2‐isopropylacetamide and 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine. A cDNA library was constructed from drug‐induced liver mRNA and clones containing sequences coding for 5‐aminolevulinate synthase were identified by hybrid‐selected translation. The identity of these clones was confirmed by comparing DNA sequence data with the amino acid sequence of peptides from purified 5‐aminolevulinate synthase.From Northern blot analysis the size of the mRNA for 5‐aminolevulinate synthase was estimated to be 2800 base pairs, approximately 600 base pairs more than that required to code for the primary translation product of relative molecular mass 74000.

Bibliography

BORTHWICK, I. A., SRIVASTAVA, G., HOBBS, A. A., PIROLA, B. A., BROOKER, J. D., MAY, B. K., & ELLIOTT, W. H. (1984). Molecular cloning of hepatic 5âaminolevulinate synthase. European Journal of Biochemistry, 144(1), 95â99. Portico.

Authors 7

Iain A. BORTHWICK (first)
Gopesh SRIVASTAVA (additional)
Andrew A. HOBBS (additional)
Byron A. PIROLA (additional)
John D. BROOKER (additional)
Brian K. MAY (additional)
William H. ELLIOTT (additional)

References 21 Referenced 9

{'key': 'e_1_2_3_2_2', 'volume': '11', 'author': 'Sassa S.', 'year': '1981', 'journal-title': 'Adv. Hum. Genet.'} / Adv. Hum. Genet. by Sassa S. (1981)
{'key': 'e_1_2_3_3_2', 'first-page': '129', 'volume': '44', 'author': 'Matteis F.', 'year': '1978', 'journal-title': 'Handb. Expt. Pharmacol'} / Handb. Expt. Pharmacol by Matteis F. (1978)
10.1016/S0021-9258(18)96783-9
{'key': 'e_1_2_3_5_2', 'first-page': '111', 'volume-title': 'Advances in Pharmacology and Thera peutics', 'author': 'Meyer U. A.', 'year': '1982'} / Advances in Pharmacology and Thera peutics by Meyer U. A. (1982)
10.1111/j.1432-1033.1982.tb07055.x / Eur. J. Biochem. by Brooker J. D. (1982)
10.1111/j.1432-1033.1983.tb07745.x
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10.1111/j.1432-1033.1983.tb07093.x / Eur. J. Biochem. by Borthwick I. A. (1982)
10.1016/0014-5793(84)80099-X
{'key': 'e_1_2_3_11_2', 'first-page': '782', 'volume': '188', 'author': 'Srivastava G.', 'year': '1988', 'journal-title': 'Biochem. J.'} / Biochem. J. by Srivastava G. (1988)
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{'key': 'e_1_2_3_14_2', 'volume-title': 'Molecular Cloning', 'author': 'Maniatis T.', 'year': '1982'} / Molecular Cloning by Maniatis T. (1982)
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10.1016/S0076-6879(83)91038-8
10.1016/0006-291X(83)91254-8
10.1007/BF00849277

Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 6:15 p.m.)
Deposited	1 year, 9 months ago (Nov. 22, 2023, 4:48 p.m.)
Indexed	1 year, 9 months ago (Nov. 22, 2023, 5:25 p.m.)
Issued	40 years, 11 months ago (Oct. 1, 1984)
Published	40 years, 11 months ago (Oct. 1, 1984)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	40 years, 11 months ago (Oct. 1, 1984)

Funders 0

None

BibTeX

@article{BORTHWICK_1984, title={Molecular cloning of hepatic 5‐aminolevulinate synthase}, volume={144}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1984.tb08435.x}, DOI={10.1111/j.1432-1033.1984.tb08435.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={BORTHWICK, Iain A. and SRIVASTAVA, Gopesh and HOBBS, Andrew A. and PIROLA, Byron A. and BROOKER, John D. and MAY, Brian K. and ELLIOTT, William H.}, year={1984}, month=oct, pages={95–99} }

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