DOI: 10.1111/j.1432-1033.1982.tb06467.x. Competition of Rifampicin with Binding of Substrate and RNA to RNA Polymerase

Competition of Rifampicin with Binding of Substrate and RNA to RNA Polymerase

10.1111/j.1432-1033.1982.tb06467.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

The rate of formation of dinucleoside tetraphosphate, pppApU, from ATP and UTP by RNA polymerase on the A 1 promoter of the mutant Dl11 of bacteriophage T7 is distinctly and specifically reduced not only by the third template‐directed nucleotide, CTP, but also by CMP. The inhibitory effect of CMP is not changed when the enzyme contains prebound rifampicin. The synthesis of pppApU is also strongly reduced after preincubation of thc enzyme with RNA. This inhibitory effect of RNA is, however, distinctly diminished by rifampicin bound to the enzyme prior to the addition of RNA. On the other hand RNA can suppress the specific binding of the antibiotic to the RNA polymerase subassembly α2β.

Bibliography

KESSLER, C., Huaifeng, M., & HARTMANN, G. R. (1982). Competition of Rifampicin with Binding of Substrate and RNA to RNA Polymerase. European Journal of Biochemistry, 122(3), 515â518. Portico.

Authors 3

Christoph KESSLER (first)
MI Huaifeng (additional)
Gsuido R. HARTMANN (additional)

References 41 Referenced 10

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Kessler C.(1980)Doctoral Thesis Fakultät Für Chemie und Pharmazie der Ludwig‐aximilians‐Universität München.
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{'key': 'e_1_2_2_17_2', 'first-page': '2026', 'author': 'Kiev B.', 'year': '1967', 'journal-title': 'Chem Ind. (Lond.)'} / Chem Ind. (Lond.) by Kiev B. (1967)
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Dates

Type	When
Created	15 years, 1 month ago (July 22, 2010, 5:06 a.m.)
Deposited	1 year, 9 months ago (Nov. 23, 2023, 3:39 a.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 7:07 p.m.)
Issued	43 years, 6 months ago (March 1, 1982)
Published	43 years, 6 months ago (March 1, 1982)
Published Online	20 years, 6 months ago (March 3, 2005)
Published Print	43 years, 6 months ago (March 1, 1982)

Funders 0

None

BibTeX

@article{KESSLER_1982, title={Competition of Rifampicin with Binding of Substrate and RNA to RNA Polymerase}, volume={122}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1982.tb06467.x}, DOI={10.1111/j.1432-1033.1982.tb06467.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={KESSLER, Christoph and Huaifeng, MI and HARTMANN, Gsuido R.}, year={1982}, month=mar, pages={515–518} }

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