DOI: 10.1111/j.1432-1033.1981.tb05484.x. Concerning the Mode of Action of Micrococcin upon Bacterial Protein Synthesis

Concerning the Mode of Action of Micrococcin upon Bacterial Protein Synthesis

10.1111/j.1432-1033.1981.tb05484.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

The antibiotic, micrococcin, binds to complexes, formed between bacterial 23‐S ribosomal RNA and ribosomal protein L11 and, in doing so, inhibits the binding of thiostrepton. In assay systems simulating partial reactions of protein synthesis, micrococcin inhibits a number of processes believed to involve the ribosomal A site while stimulating GTP hydrolysis dependent upon ribosomes and elongation factor EF‐G. The latter effect is not observed upon ribosomes lacking a protein homologous with protein L11. Nor is it apparent upon those containing 23‐S RNA previously subjected to the action of a specific methylase known to render ribosomes resistant to thiostrepton. It is concluded that stimulation by micrococcin of factor‐dependent GTP hydrolysis results from the binding of the drug to its normal target site which involves 23‐S RNA and protein L11.

Bibliography

CUNDLIFFE, E., & THOMPSON, J. (1981). Concerning the Mode of Action of Micrococcin upon Bacterial Protein Synthesis. European Journal of Biochemistry, 118(1), 47â52. Portico.

Authors 2

Eric CUNDLIFFE (first)
Jill THOMPSON (additional)

References 39 Referenced 60

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Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 4:15 p.m.)
Deposited	1 year, 9 months ago (Nov. 23, 2023, 2:18 a.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:46 p.m.)
Issued	44 years ago (Aug. 1, 1981)
Published	44 years ago (Aug. 1, 1981)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	44 years ago (Aug. 1, 1981)

Funders 0

None

BibTeX

@article{CUNDLIFFE_1981, title={Concerning the Mode of Action of Micrococcin upon Bacterial Protein Synthesis}, volume={118}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1981.tb05484.x}, DOI={10.1111/j.1432-1033.1981.tb05484.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={CUNDLIFFE, Eric and THOMPSON, Jill}, year={1981}, month=aug, pages={47–52} }

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