DOI: 10.1111/j.1432-1033.1981.tb05483.x. Immunochemical Studies of Human Placental‐Type Variants of Alkaline Phosphatase

Immunochemical Studies of Human Placental‐Type Variants of Alkaline Phosphatase

10.1111/j.1432-1033.1981.tb05483.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

Hyperimmune antisera raised against the rare FD and SD phenotypes of human placental alkaline phosphatase and the related cancer‐associated Nagao isoenzyme were exhaustively absorbed with the common SS and FF phenotype enzymes conjugated to Sepharose. The antibodies so obtained had one of three specificities, determined by testing all the common phenotypes of placental alkaline phosphatase, the rare FD, SD and S‐17 phenotypes, and five samples of purified cancer patient enzymes: (I) antibodies reactive with the S, D and I variant enzymes, but not with the F, 17 or Nagao enzymes; (II) antibodies reactive with the F, 17 and Nagao enzymes, but not with the S, D and I variant enzymes; and (III) antibodies reactive with the D, 17 and Nagao enzymes and not with the S, F or I variant enzymes. Based on these data, and on the information obtained from biochemical characterization, it is argued that the Nagao isoenzyme and the D‐variant are closely related but distinct enzymes. We propose a hypothetical scheme for the divergence of these two enzymes from a common ancestral gene product. In this scheme, an ancestral gene duplication resulted in two isoenzymes, one, of which is completely specific to the placenta, and one of which (the ‘Nagao isoenzyme’) has an unknown normal tissue localization, but is found in some cases of cancer. We use the term ‘syn‐placental’ to describe this latter isoenzyme, reflecting its close structural relationship to the placental isoenzyme.

Bibliography

WEI, S. C., & DOELLGAST, G. J. (1981). Immunochemical Studies of Human PlacentalâType Variants of Alkaline Phosphatase. European Journal of Biochemistry, 118(1), 39â45. Portico.

Authors 2

Shirley C. WEI (first)
George J. DOELLGAST (additional)

References 39 Referenced 12

10.1038/2071257a0
10.1111/j.0954-6820.1968.tb10520.x / Acta Genet. Stat. Med. by Beckman L. (1968)
10.1111/j.1469-1809.1974.tb01837.x
{'key': 'e_1_2_3_5_2', 'first-page': '1657', 'volume': '33', 'author': 'Inglis N. R.', 'year': '1973', 'journal-title': 'Cancer Res.'} / Cancer Res. by Inglis N. R. (1973)
10.1111/j.1749-6632.1963.tb53746.x
10.1016/S0021-9258(18)99338-5
10.1016/0002-9343(74)90631-7
10.1073/pnas.73.7.2201
10.1042/bj1810067
10.1007/BF00504347
{'key': 'e_1_2_3_12_2', 'volume-title': 'The Principles of Human Biochemical Genetics', 'author': 'Harris H.', 'year': '1975'} / The Principles of Human Biochemical Genetics by Harris H. (1975)
10.1038/219697a0
{'key': 'e_1_2_3_14_2', 'first-page': '251', 'volume': '37', 'author': 'Manning J. P.', 'year': '1969', 'journal-title': 'Enzymologia, mologia'} / Enzymologia, mologia by Manning J. P. (1969)
10.1038/280602a0
10.1038/280601a0
10.1111/j.1469-1809.1974.tb01832.x
10.1159/000152526
10.1111/j.1601-5223.1975.tb01018.x
10.1016/0009-8981(70)90152-X
10.1007/BF00520195 / Biochem. Genet. by Holmgren P. Å. (1979)
{'key': 'e_1_2_3_22_2', 'first-page': '85', 'volume': '24', 'author': 'Docugast G. J.', 'year': '1976', 'journal-title': 'Protides Biol. Fluids Proc. Colloq. Bruges'} / Protides Biol. Fluids Proc. Colloq. Bruges by Docugast G. J. (1976)
10.1016/0005-2744(77)90113-9
10.1016/0022-1759(79)90222-9
10.1007/BF00484341
10.1515/bchm2.1968.349.2.1755
10.1016/0003-2697(77)90164-6
10.1159/000152296
10.1159/000153082 / Hum. Hered. by Doellgast G. J. (1980)
10.1038/259049a0
{'key': 'e_1_2_3_31_2', 'first-page': '1506', 'volume': '40', 'author': 'Chang C. H.', 'year': '1980', 'journal-title': 'Cancer Res.'} / Cancer Res. by Chang C. H. (1980)
10.1016/0009-8981(77)90365-5
10.1016/0009-8981(75)90251-X
{'key': 'e_1_2_3_34_2', 'first-page': '737', 'volume-title': 'Onco‐Developmental Gene Expression', 'author': 'Doellgast G. J.', 'year': '1976'} / Onco‐Developmental Gene Expression by Doellgast G. J. (1976)
10.1016/0009-8981(77)90373-4
10.1111/j.1749-6632.1975.tb25429.x
10.1159/000152926 / Hum. Hered. by Donald L. J. (1978)
10.1016/S0065-2776(08)60207-2
10.1016/S0065-3233(08)60413-1
10.1146/annurev.bi.46.070177.003041

Dates

Type	When
Created	20 years, 6 months ago (March 3, 2005, 4:15 p.m.)
Deposited	1 year, 9 months ago (Nov. 23, 2023, 2:19 a.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 5:20 p.m.)
Issued	44 years, 1 month ago (Aug. 1, 1981)
Published	44 years, 1 month ago (Aug. 1, 1981)
Published Online	20 years, 6 months ago (March 3, 2005)
Published Print	44 years, 1 month ago (Aug. 1, 1981)

Funders 0

None

BibTeX

@article{WEI_1981, title={Immunochemical Studies of Human Placental‐Type Variants of Alkaline Phosphatase: Structural Differences between the ‘Nagao Isoenzyme’ and the Placental ‘D–Variant’}, volume={118}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1981.tb05483.x}, DOI={10.1111/j.1432-1033.1981.tb05483.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={WEI, Shirley C. and DOELLGAST, George J.}, year={1981}, month=aug, pages={39–45} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        11,
        23
      ]
    ],
    "date-time": "2023-11-23T22:20:24Z",
    "timestamp": 1700778024254
  },
  "reference-count": 39,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            3,
            3
          ]
        ],
        "date-time": "2005-03-03T00:00:00Z",
        "timestamp": 1109808000000
      },
      "content-version": "vor",
      "delay-in-days": 8615,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1981,
        8
      ]
    ]
  },
  "abstract": "<jats:p>Hyperimmune antisera raised against the rare FD and SD phenotypes of human placental alkaline phosphatase and the related cancer\u2010associated Nagao isoenzyme were exhaustively absorbed with the common SS and FF phenotype enzymes conjugated to Sepharose. The antibodies so obtained had one of three specificities, determined by testing all the common phenotypes of placental alkaline phosphatase, the rare FD, SD and S\u201017 phenotypes, and five samples of purified cancer patient enzymes: (I) antibodies reactive with the S, D and I variant enzymes, but not with the F, 17 or Nagao enzymes; (II) antibodies reactive with the F, 17 and Nagao enzymes, but not with the S, D and I variant enzymes; and (III) antibodies reactive with the D, 17 and Nagao enzymes and not with the S, F or I variant enzymes. Based on these data, and on the information obtained from biochemical characterization, it is argued that the Nagao isoenzyme and the D\u2010variant are closely related but distinct enzymes. We propose a hypothetical scheme for the divergence of these two enzymes from a common ancestral gene product. In this scheme, an ancestral gene duplication resulted in two isoenzymes, one, of which is completely specific to the placenta, and one of which (the \u2018Nagao isoenzyme\u2019) has an unknown normal tissue localization, but is found in some cases of cancer. We use the term \u2018syn\u2010placental\u2019 to describe this latter isoenzyme, reflecting its close structural relationship to the placental isoenzyme.</jats:p>",
  "DOI": "10.1111/j.1432-1033.1981.tb05483.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        3,
        3
      ]
    ],
    "date-time": "2005-03-03T21:15:41Z",
    "timestamp": 1109884541000
  },
  "page": "39-45",
  "source": "Crossref",
  "is-referenced-by-count": 12,
  "title": "Immunochemical Studies of Human Placental\u2010Type Variants of Alkaline Phosphatase",
  "prefix": "10.1111",
  "volume": "118",
  "author": [
    {
      "given": "Shirley C.",
      "family": "WEI",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "George J.",
      "family": "DOELLGAST",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2005,
        3,
        3
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_3_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/2071257a0"
    },
    {
      "key": "e_1_2_3_3_2",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1111/j.0954-6820.1968.tb10520.x",
      "volume": "18",
      "author": "Beckman L.",
      "year": "1968",
      "journal-title": "Acta Genet. Stat. Med."
    },
    {
      "key": "e_1_2_3_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1469-1809.1974.tb01837.x"
    },
    {
      "key": "e_1_2_3_5_2",
      "first-page": "1657",
      "volume": "33",
      "author": "Inglis N. R.",
      "year": "1973",
      "journal-title": "Cancer Res."
    },
    {
      "key": "e_1_2_3_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1963.tb53746.x"
    },
    {
      "key": "e_1_2_3_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)99338-5"
    },
    {
      "key": "e_1_2_3_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0002-9343(74)90631-7"
    },
    {
      "key": "e_1_2_3_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.73.7.2201"
    },
    {
      "key": "e_1_2_3_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj1810067"
    },
    {
      "key": "e_1_2_3_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00504347"
    },
    {
      "key": "e_1_2_3_12_2",
      "volume-title": "The Principles of Human Biochemical Genetics",
      "author": "Harris H.",
      "year": "1975"
    },
    {
      "key": "e_1_2_3_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/219697a0"
    },
    {
      "key": "e_1_2_3_14_2",
      "first-page": "251",
      "volume": "37",
      "author": "Manning J. P.",
      "year": "1969",
      "journal-title": "Enzymologia, mologia"
    },
    {
      "key": "e_1_2_3_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/280602a0"
    },
    {
      "key": "e_1_2_3_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/280601a0"
    },
    {
      "key": "e_1_2_3_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1469-1809.1974.tb01832.x"
    },
    {
      "key": "e_1_2_3_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000152526"
    },
    {
      "key": "e_1_2_3_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1601-5223.1975.tb01018.x"
    },
    {
      "key": "e_1_2_3_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0009-8981(70)90152-X"
    },
    {
      "key": "e_1_2_3_21_2",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1007/BF00520195",
      "volume": "15",
      "author": "Holmgren P. \u00c5.",
      "year": "1979",
      "journal-title": "Biochem. Genet."
    },
    {
      "key": "e_1_2_3_22_2",
      "first-page": "85",
      "volume": "24",
      "author": "Docugast G. J.",
      "year": "1976",
      "journal-title": "Protides Biol. Fluids Proc. Colloq. Bruges"
    },
    {
      "key": "e_1_2_3_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0005-2744(77)90113-9"
    },
    {
      "key": "e_1_2_3_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0022-1759(79)90222-9"
    },
    {
      "key": "e_1_2_3_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00484341"
    },
    {
      "key": "e_1_2_3_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1515/bchm2.1968.349.2.1755"
    },
    {
      "key": "e_1_2_3_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0003-2697(77)90164-6"
    },
    {
      "key": "e_1_2_3_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000152296"
    },
    {
      "key": "e_1_2_3_29_2",
      "doi-asserted-by": "crossref",
      "first-page": "18",
      "DOI": "10.1159/000153082",
      "volume": "30",
      "author": "Doellgast G. J.",
      "year": "1980",
      "journal-title": "Hum. Hered."
    },
    {
      "key": "e_1_2_3_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/259049a0"
    },
    {
      "key": "e_1_2_3_31_2",
      "first-page": "1506",
      "volume": "40",
      "author": "Chang C. H.",
      "year": "1980",
      "journal-title": "Cancer Res."
    },
    {
      "key": "e_1_2_3_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0009-8981(77)90365-5"
    },
    {
      "key": "e_1_2_3_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0009-8981(75)90251-X"
    },
    {
      "key": "e_1_2_3_34_2",
      "first-page": "737",
      "volume-title": "Onco\u2010Developmental Gene Expression",
      "author": "Doellgast G. J.",
      "year": "1976"
    },
    {
      "key": "e_1_2_3_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0009-8981(77)90373-4"
    },
    {
      "key": "e_1_2_3_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1975.tb25429.x"
    },
    {
      "key": "e_1_2_3_37_2",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1159/000152926",
      "volume": "28",
      "author": "Donald L. J.",
      "year": "1978",
      "journal-title": "Hum. Hered."
    },
    {
      "key": "e_1_2_3_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0065-2776(08)60207-2"
    },
    {
      "key": "e_1_2_3_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0065-3233(08)60413-1"
    },
    {
      "key": "e_1_2_3_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.46.070177.003041"
    }
  ],
  "container-title": "European Journal of Biochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1432-1033.1981.tb05483.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1981.tb05483.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        23
      ]
    ],
    "date-time": "2023-11-23T07:19:25Z",
    "timestamp": 1700723965000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1981.tb05483.x"
    }
  },
  "subtitle": [
    "Structural Differences between the \u2018Nagao Isoenzyme\u2019 and the Placental \u2018D\u2013Variant\u2019"
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1981,
        8
      ]
    ]
  },
  "references-count": 39,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1981,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1432-1033.1981.tb05483.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1432-1033.1981.tb05483.x",
  "relation": {},
  "ISSN": [
    "0014-2956",
    "1432-1033"
  ],
  "subject": [],
  "container-title-short": "European Journal of Biochemistry",
  "published": {
    "date-parts": [
      [
        1981,
        8
      ]
    ]
  }
}