DOI: 10.1111/j.1432-1033.1980.tb04983.x. The Inhibition and Activation of Ca<sup>2+</sup>‐Dependent Phosphatidylinositol Phosphodiesterase by Phospholipids and Blood Plasma

The Inhibition and Activation of Ca2+‐Dependent Phosphatidylinositol Phosphodiesterase by Phospholipids and Blood Plasma

10.1111/j.1432-1033.1980.tb04983.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

Phosphatidylinositol‐phosphodiesterase (EC 3.1.4.10) was strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain lengths of more than eight carbon atoms were mixed with its substrate. In contrast, dihexanoylglycerophosphocholine produces a marked activation attended by a breakdown of the bilayer structure of the substrate. C12, C14 and C16 lysophosphatidylcholines gave a progressive inhibition of the enzyme with increasing chain length; C10 lysophosphatidylcholine activated the reaction. The enzyme was strongly inhibited by blood plasma and serum and by blood lipoproteins. Phosphatidic acid, and certain lysophosphatidic acids (oleoyl and palmitoylglycerophosphates) activated the hydrolysis at a physiological pH, whereas decanoylglycerophosphate had little effect. Phosphatidic acid at a concentration of 1% molar total lipid P produced an enhancement of the hydrolysis of the phosphatidylinositol substrate contained in a lipid environment which approximated to the inner (cytoplasmic) lamella of the plasma membrane bilayer of the liver sinusoidal cell surface. The possible role of phospholipid molecules adjacent to phosphatidylinositol in controlling the hydrolysis of the latter in the proximity of a cell surface receptor is discussed. It is suggested that phosphatidic acid formed by the action of diacylglycerol kinase could amplify any increased hydrolysis of phosphatidylinositol which results from stimulation of the cell by an agonist.

Bibliography

DAWSON, R. M. C., HEMINGTON, N., & IRVINE, R. F. (1980). The Inhibition and Activation of Ca2+âDependent Phosphatidylinositol Phosphodiesterase by Phospholipids and Blood Plasma. European Journal of Biochemistry, 112(1), 33â38. Portico.

Authors 3

Rex M. C. DAWSON (first)
Norma HEMINGTON (additional)
Robin F. IRVINE (additional)

References 21 Referenced 41

{'key': 'e_1_2_2_2_2', 'first-page': '423', 'volume-title': 'Metabolism and Physiological Significance of Lipids', 'author': 'Hokin M. R.', 'year': '1964'} / Metabolism and Physiological Significance of Lipids by Hokin M. R. (1964)
10.1016/0304-4157(75)90017-9
10.1016/B978-0-12-741750-9.50031-8
10.1042/bj1780045
10.1042/bj1780497
10.1111/j.1471-4159.1978.tb06568.x
10.1111/j.1432-1033.1979.tb13284.x
10.1007/978-1-4684-3276-3_40 / Adv. Exp. Med. Biol. by Hokin‐Neaverson M. (1978)
10.1099/00221287-89-1-163
10.1042/bj1760475
10.1042/bj0840497
10.1042/bj1020076
10.1042/bj1740563
10.1016/0005-2736(72)90307-0
{'key': 'e_1_2_2_16_2', 'first-page': '15', 'volume': '69', 'author': 'Lumb R. H.', 'year': '1976', 'journal-title': 'Fur. J. Biochem.'} / Fur. J. Biochem. by Lumb R. H. (1976)
10.1016/0005-2760(76)90186-7
10.1016/0003-9861(76)90388-X
10.1042/bj0770226
10.1007/BF02533598
10.1042/bst0080027 / Biochem. Soc. Trans. by Irvine R. F. (1980)
10.1111/j.1365-2141.1973.tb01685.x / Brit. J. Haematol. by Lloyd J. V.

Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 3:40 p.m.)
Deposited	1 year, 8 months ago (Nov. 23, 2023, 1:59 p.m.)
Indexed	1 year, 3 months ago (May 9, 2024, 3:10 a.m.)
Issued	44 years, 9 months ago (Nov. 1, 1980)
Published	44 years, 9 months ago (Nov. 1, 1980)
Published Online	20 years, 5 months ago (March 3, 2005)
Published Print	44 years, 9 months ago (Nov. 1, 1980)

Funders 0

None

BibTeX

@article{DAWSON_1980, title={The Inhibition and Activation of Ca2+‐Dependent Phosphatidylinositol Phosphodiesterase by Phospholipids and Blood Plasma}, volume={112}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1980.tb04983.x}, DOI={10.1111/j.1432-1033.1980.tb04983.x}, number={1}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={DAWSON, Rex M. C. and HEMINGTON, Norma and IRVINE, Robin F.}, year={1980}, month=nov, pages={33–38} }

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