DOI: 10.1111/j.1432-1033.1979.tb13284.x. The Calcium‐Dependent Phosphatidylinositol‐Phosphodiesterase of Rat Brain

The Calcium‐Dependent Phosphatidylinositol‐Phosphodiesterase of Rat Brain

10.1111/j.1432-1033.1979.tb13284.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

1. The activity of the soluble, calcium‐dependent phosphatidylinositol‐specific phosphodiesterase (EC 3.1.4.10) against [32P] phosphatidylinositol has been investigated.2. KCl (only at neutral pH), Mg2+, positively‐charged proteins such as histone, and phospholipids containing a choline headgroup are all inhibitory to the enzyme. Choline‐phospholipids cause a 90% inhibition at an equimolar ratio to phosphatidylinositol.3. Other phospholipids (phosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and phosphatidic acid) are all potent stimulators of the enzyme: maximum stimulation being observed at a ratio of 1 mol activator/5–10 mol phosphatidylinositol.4. Unsaturated amphiphiles such as oleic and oleoyl alcohol also stimulate the activity, maximum stimulation being observed at about an equimolar ratio to phosphatidylinositol. Saturated amphiphiles (such as stearic acid and stearoyl alcohol) are less effective.5. The activation by acidic phospholipids and unsaturated amphiphiles appear to be independent as they are additive and, under certain conditions, synergistic.6. Both types of stimulator (independently or together) can reverse the inhibition caused by histone or phosphatidylcholine.7. Possible mechanisms of the suppression of the phosphatidylinositol phosphodiesterase in vivo, of its activation, and of the amplification of phosphatidylinositol breakdown are discussed.

Bibliography

IRVINE, R. F., HEMINGTON, N., & DAWSON, R. M. C. (1979). The CalciumâDependent PhosphatidylinositolâPhosphodiesterase of Rat Brain. European Journal of Biochemistry, 99(3), 525â530. Portico.

Authors 3

Robin F. IRVINE (first)
Norma HEMINGTON (additional)
Rex M. C. DAWSON (additional)

References 27 Referenced 67

10.1016/0304-4157(75)90017-9
10.1016/0006-3002(59)90499-8
10.1042/bj0790193
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10.1139/o67-095
10.1042/bj1640277
10.1042/bj1760475
10.1111/j.1471-4159.1969.tb10376.x
10.1042/bj1310433
10.1111/j.1471-4159.1978.tb06568.x
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10.1042/bj1120091
10.1042/bj1020076
{'key': 'e_1_2_2_17_2', 'first-page': '441', 'volume-title': 'Form and Function of phospholipids', 'author': 'White D. A.', 'year': '1973'} / Form and Function of phospholipids by White D. A. (1973)
10.1016/0006-291X(73)90518-4 / Biochem. Biophys. Res. Commun. by Onishi S. (1973)
10.1021/bi00630a003
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10.1042/bj1740413
10.1016/S0074-7696(08)60272-7
10.1042/bj1660495
10.1016/S0021-9258(17)33743-2
10.1007/BF02533598
10.1111/j.2042-7158.1979.tb13444.x / J. Pharm. Pharmacol. by Tsukatari H. (1979)
10.1042/bj1540653

Dates

Type	When
Created	20 years, 5 months ago (March 3, 2005, 3:08 p.m.)
Deposited	1 year, 9 months ago (Nov. 22, 2023, 5:38 p.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 4:38 p.m.)
Issued	45 years, 11 months ago (Sept. 1, 1979)
Published	45 years, 11 months ago (Sept. 1, 1979)
Published Online	17 years, 1 month ago (June 28, 2008)
Published Print	45 years, 11 months ago (Sept. 1, 1979)

Funders 0

None

BibTeX

@article{IRVINE_1979, title={The Calcium‐Dependent Phosphatidylinositol‐Phosphodiesterase of Rat Brain: Mechanisms of Suppression and Stimulation}, volume={99}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1979.tb13284.x}, DOI={10.1111/j.1432-1033.1979.tb13284.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={IRVINE, Robin F. and HEMINGTON, Norma and DAWSON, Rex M. C.}, year={1979}, month=sep, pages={525–530} }

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