DOI: 10.1111/j.1432-1033.1978.tb12372.x. Perinatal Changes in Liver Corticosterone, Serum Insulain and Plasma Glucagon and Corticosterone in the Rat

Perinatal Changes in Liver Corticosterone, Serum Insulain and Plasma Glucagon and Corticosterone in the Rat

10.1111/j.1432-1033.1978.tb12372.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

This report describes some hormonal changes occuring in the rat during the last 3 days of gestation and the first 6 h after surgical deliversy on days 20–22uu ofgestation. In the foetus, the concentration of glucagon increased 2‐fold and that of insulin decreaed from 4.7 to 3.5 ng/ml between days 21 and 22. Consequently the insulin/glucagon molar ratio decreased from 15.6 on day 21 to 5.9 on day 22. After delivery on dasys 21 and 22 of gestation plama glucagon concentration increased 2‐fold and reeached a maximim at 30 min after birth. In addition, the concentration of serum insulin decreased to about 50% of the foetal values by 30 min post partum. Consequentaly the insulin/glucagon ratio decreased to a minimum 30 min after delivery. There was no sinificant change in the concentration of total, that bound to corticosteroid‐binding globulin and free corticosterone in the plasma nor in the concentration of liver corticosterone for 6 h after delivery on day 22 of gestation. Only free plasma corticosterone concentration increased after delivery on day 21 and peaked one hour after birth. The concentration of both pancreatic hommones and corticosterone showed a different development pattern after premauature delivery on day 20 of gestatin. Plasma glucagon increased and plasma insulin decreased for 2 h. Consequentaly the insulin/glucagon ratio decreased from 8.8 at birth to 2.4 at 2 h post partum. The concentration liver corticosterone as well as total, bound and free corticosterone in the plsma incrreased to maximal levels within 1–2 h ofdelivery. The results support the proposal that the relative concentration of insulin and glucagon in the blood regulate the adenosine 3′:5′‐monophosphate concentration and thus enzyme induction in the liver of the perinatal rat. However, the changes in corticosterone concentration wer not consistent with the view that steroids are a primary signal for tyrosine sminotransferase induciton in the newborn rat.

Bibliography

DI MARCO, P. N., GHISALBERTI, A. V., MARTIM, C. E., & OLIVER, Ivan. T. (1978). Perinatal Changes in Liver Corticosterone, Serum Insulain and Plasma Glucagon and Corticosterone in the Rat. European Journal of Biochemistry, 87(2), 243â247. Portico.

Authors 4

Peter N. DI MARCO (first)
Ann V. GHISALBERTI (additional)
Clayton E. MARTIM (additional)
Ivan. T. OLIVER (additional)

References 26 Referenced 25

{'key': 'e_1_2_4_2_2', 'first-page': '272', 'volume': '15', 'author': 'Girard J. R.', 'year': '1973', 'journal-title': 'Enzyme (Basel)'} / Enzyme (Basel) by Girard J. R. (1973)
10.1159/000240922
10.1111/j.1432-1033.1978.tb12372.x / Eur. J. Biochem. by Marco P. N. (1978)
{'key': 'e_1_2_4_5_2', 'first-page': '957', 'volume': '83', 'author': 'Blázquez E.', 'year': '1974', 'journal-title': 'J. Lab. Clin. Med.'} / J. Lab. Clin. Med. by Blázquez E. (1974)
10.1055/s-0028-1094093
10.1172/JCI107519
10.1016/S0021-9258(18)70254-8
10.1021/bi00832a018
10.1042/bj1080339
{'key': 'e_1_2_4_11_2', 'first-page': '99', 'volume': '278', 'author': 'Corbier P.', 'year': '1974', 'journal-title': 'C. R. Hebd. Seances Acad. Sci. Paris'} / C. R. Hebd. Seances Acad. Sci. Paris by Corbier P. (1974)
10.1007/BF01965349
10.1007/BF00996319
10.2337/diab.12.2.115
10.1530/acta.0.0840167
10.2337/diab.23.4.310
10.1016/S0021-9258(18)93618-5
{'key': 'e_1_2_4_18_2', 'first-page': '411', 'volume': '26', 'author': 'Exton J. H.', 'year': '1970', 'journal-title': 'Recent Prog. Horm. Res'} / Recent Prog. Horm. Res by Exton J. H. (1970)
{'key': 'e_1_2_4_19_2', 'first-page': '437', 'volume-title': 'Handbook of Physiology', 'author': 'Exton J. H.', 'year': '1972'} / Handbook of Physiology by Exton J. H. (1972)
10.1016/S0021-9258(19)41070-3
10.1210/endo-99-5-1313
10.1210/endo-100-5-1443 / Endocarinology by Eguchi Y. (1977)
{'key': 'e_1_2_4_23_2', 'first-page': '199', 'volume-title': 'Methods Horm. Res.', 'author': 'Peron F. G.', 'year': '1962'} / Methods Horm. Res. by Peron F. G. (1962)
{'key': 'e_1_2_4_24_2', 'first-page': '593', 'volume': '29', 'author': 'Chanez C.', 'year': '1972', 'journal-title': 'Arch. Fr. Pédiatr.'} / Arch. Fr. Pédiatr. by Chanez C. (1972)
{'key': 'e_1_2_4_25_2', 'first-page': '400', 'volume': '22', 'author': 'Cohn A.', 'year': '1974', 'journal-title': 'Gen.Comp. Endocirnol.'} / Gen.Comp. Endocirnol. by Cohn A. (1974)
10.1016/0304-4165(64)90270-3
10.1210/endo-85-4-778

Dates

Type	When
Created	20 years, 6 months ago (March 3, 2005, 1:49 p.m.)
Deposited	1 year, 9 months ago (Nov. 23, 2023, 7:34 a.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 11:37 a.m.)
Issued	47 years, 3 months ago (June 1, 1978)
Published	47 years, 3 months ago (June 1, 1978)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	47 years, 3 months ago (June 1, 1978)

Funders 0

None

BibTeX

@article{DI_MARCO_1978, title={Perinatal Changes in Liver Corticosterone, Serum Insulain and Plasma Glucagon and Corticosterone in the Rat}, volume={87}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1978.tb12372.x}, DOI={10.1111/j.1432-1033.1978.tb12372.x}, number={2}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={DI MARCO, Peter N. and GHISALBERTI, Ann V. and MARTIM, Clayton E. and OLIVER, Ivan. T.}, year={1978}, month=jun, pages={243–247} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        11,
        23
      ]
    ],
    "date-time": "2023-11-23T16:37:07Z",
    "timestamp": 1700757427545
  },
  "reference-count": 26,
  "publisher": "Wiley",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            6,
            28
          ]
        ],
        "date-time": "2008-06-28T00:00:00Z",
        "timestamp": 1214611200000
      },
      "content-version": "vor",
      "delay-in-days": 10985,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1978,
        6
      ]
    ]
  },
  "abstract": "<jats:p>This report describes some hormonal changes occuring in the rat during the last 3 days of gestation and the first 6 h after surgical deliversy on days 20\u201322uu ofgestation. In the foetus, the concentration of glucagon increased 2\u2010fold and that of insulin decreaed from 4.7 to 3.5 ng/ml between days 21 and 22. Consequently the insulin/glucagon molar ratio decreased from 15.6 on day 21 to 5.9 on day 22. After delivery on dasys 21 and 22 of gestation plama glucagon concentration increased 2\u2010fold and reeached a maximim at 30 min after birth. In addition, the concentration of serum insulin decreased to about 50% of the foetal values by 30 min <jats:italic>post partum</jats:italic>. Consequentaly the insulin/glucagon ratio decreased to a minimum 30 min after delivery. There was no sinificant change in the concentration of total, that bound to corticosteroid\u2010binding globulin and free corticosterone in the plasma nor in the concentration of liver corticosterone for 6 h after delivery on day 22 of gestation. Only free plasma corticosterone concentration increased after delivery on day 21 and peaked one hour after birth. The concentration of both pancreatic hommones and corticosterone showed a different development pattern after premauature delivery on day 20 of gestatin. Plasma glucagon increased and plasma insulin decreased for 2 h. Consequentaly the insulin/glucagon ratio decreased from 8.8 at birth to 2.4 at 2 h <jats:italic>post partum</jats:italic>. The concentration liver corticosterone as well as total, bound and free corticosterone in the plsma incrreased to maximal levels within 1\u20132 h ofdelivery. The results support the proposal that the relative concentration of insulin and glucagon in the blood regulate the adenosine 3\u2032:5\u2032\u2010monophosphate concentration and thus enzyme induction in the liver of the perinatal rat. However, the changes in corticosterone concentration wer not consistent with the view that steroids are a primary signal for tyrosine sminotransferase induciton in the newborn rat.</jats:p>",
  "DOI": "10.1111/j.1432-1033.1978.tb12372.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        3,
        3
      ]
    ],
    "date-time": "2005-03-03T18:49:43Z",
    "timestamp": 1109875783000
  },
  "page": "243-247",
  "source": "Crossref",
  "is-referenced-by-count": 25,
  "title": "Perinatal Changes in Liver Corticosterone, Serum Insulain and Plasma Glucagon and Corticosterone in the Rat",
  "prefix": "10.1111",
  "volume": "87",
  "author": [
    {
      "given": "Peter N.",
      "family": "DI MARCO",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Ann V.",
      "family": "GHISALBERTI",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Clayton E.",
      "family": "MARTIM",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ivan. T.",
      "family": "OLIVER",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2008,
        6,
        28
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_4_2_2",
      "first-page": "272",
      "volume": "15",
      "author": "Girard J. R.",
      "year": "1973",
      "journal-title": "Enzyme (Basel)"
    },
    {
      "key": "e_1_2_4_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000240922"
    },
    {
      "key": "e_1_2_4_4_2",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1111/j.1432-1033.1978.tb12372.x",
      "volume": "87",
      "author": "Marco P. N.",
      "year": "1978",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "e_1_2_4_5_2",
      "first-page": "957",
      "volume": "83",
      "author": "Bl\u00e1zquez E.",
      "year": "1974",
      "journal-title": "J. Lab. Clin. Med."
    },
    {
      "key": "e_1_2_4_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1055/s-0028-1094093"
    },
    {
      "key": "e_1_2_4_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI107519"
    },
    {
      "key": "e_1_2_4_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)70254-8"
    },
    {
      "key": "e_1_2_4_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00832a018"
    },
    {
      "key": "e_1_2_4_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj1080339"
    },
    {
      "key": "e_1_2_4_11_2",
      "first-page": "99",
      "volume": "278",
      "author": "Corbier P.",
      "year": "1974",
      "journal-title": "C. R. Hebd. Seances Acad. Sci. Paris"
    },
    {
      "key": "e_1_2_4_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF01965349"
    },
    {
      "key": "e_1_2_4_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00996319"
    },
    {
      "key": "e_1_2_4_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.2337/diab.12.2.115"
    },
    {
      "key": "e_1_2_4_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1530/acta.0.0840167"
    },
    {
      "key": "e_1_2_4_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.2337/diab.23.4.310"
    },
    {
      "key": "e_1_2_4_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)93618-5"
    },
    {
      "key": "e_1_2_4_18_2",
      "first-page": "411",
      "volume": "26",
      "author": "Exton J. H.",
      "year": "1970",
      "journal-title": "Recent Prog. Horm. Res"
    },
    {
      "key": "e_1_2_4_19_2",
      "first-page": "437",
      "volume-title": "Handbook of Physiology",
      "author": "Exton J. H.",
      "year": "1972"
    },
    {
      "key": "e_1_2_4_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)41070-3"
    },
    {
      "key": "e_1_2_4_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-99-5-1313"
    },
    {
      "key": "e_1_2_4_22_2",
      "doi-asserted-by": "crossref",
      "first-page": "1443",
      "DOI": "10.1210/endo-100-5-1443",
      "volume": "100",
      "author": "Eguchi Y.",
      "year": "1977",
      "journal-title": "Endocarinology"
    },
    {
      "key": "e_1_2_4_23_2",
      "first-page": "199",
      "volume-title": "Methods Horm. Res.",
      "author": "Peron F. G.",
      "year": "1962"
    },
    {
      "key": "e_1_2_4_24_2",
      "first-page": "593",
      "volume": "29",
      "author": "Chanez C.",
      "year": "1972",
      "journal-title": "Arch. Fr. P\u00e9diatr."
    },
    {
      "key": "e_1_2_4_25_2",
      "first-page": "400",
      "volume": "22",
      "author": "Cohn A.",
      "year": "1974",
      "journal-title": "Gen.Comp. Endocirnol."
    },
    {
      "key": "e_1_2_4_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0304-4165(64)90270-3"
    },
    {
      "key": "e_1_2_4_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/endo-85-4-778"
    }
  ],
  "container-title": "European Journal of Biochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1432-1033.1978.tb12372.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1432-1033.1978.tb12372.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        11,
        23
      ]
    ],
    "date-time": "2023-11-23T12:34:39Z",
    "timestamp": 1700742879000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1978.tb12372.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1978,
        6
      ]
    ]
  },
  "references-count": 26,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1978,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1432-1033.1978.tb12372.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1432-1033.1978.tb12372.x",
  "relation": {},
  "ISSN": [
    "0014-2956",
    "1432-1033"
  ],
  "subject": [],
  "container-title-short": "European Journal of Biochemistry",
  "published": {
    "date-parts": [
      [
        1978,
        6
      ]
    ]
  }
}