DOI: 10.1111/j.1432-1033.1977.tb11419.x. Mitochondrial Heredity of Resistance to 3‐(3,4‐Dichlorophenyl)‐1,1‐dimethylurea, an Inhibitor of Cytochrome <i>b</i> Oxidation, in <i>Saccharomyces cerevisiae</i>

Mitochondrial Heredity of Resistance to 3‐(3,4‐Dichlorophenyl)‐1,1‐dimethylurea, an Inhibitor of Cytochrome b Oxidation, in Saccharomyces cerevisiae

10.1111/j.1432-1033.1977.tb11419.x

Crossref journal-article

Wiley

European Journal of Biochemistry (311)

Abstract

3‐(3,4‐dichlorophenyl)‐1,1‐dimethylurea (diuron), an inhibitor of cytochrome b oxidation, has been used for the selection of three resistant mutants, (diur) of Saccharomyces cerevisiae. The mutant diur‐64 exhibits in vivo cross‐resistance to antimycin A while diur‐34 and diur‐1 are more sensitive to antimycin A than the parental strain. The three mutants exhibit mitochondrial inheritance according to the following criteria: mitotic segregation of diuron‐resistant and diuron‐sensitive diploids is obtained among the diploid progeny of a cross between diur and dius; non‐Mendelian segregation of diuron resistance (4:0) is observed in spores of tetrads issued from diuron‐resistant diploid; extensive ethidium bromide treatment leads to the formation of Q– mutants which no longer transmit diur and dius alleles.Evidence for two distinct diuron‐resistant loci were obtained by allelism tests. Recombination analysis shows that diuron‐resistance is not located in the polar region of the mitochondrial genome. The diur loci are not linked to the erythromycin locus since the upper limit in recombinants frequency (26%) for a non‐polar region is obtained between diur and eryr. A low recombinants frequency (3%) is observed in crosses between diur‐34 mutation and the two mutants cob1 and cob2 suggesting that diur‐34 might be located between these two cytochrome‐b‐deficient loci.The resistance to diuron is also expressed in vitro since the oxidation rates of succinate by sonicated submitochondrial particles from the mutants are clearly less sensitive to diuron than that of the wild type.

Bibliography

COLSON, A., THE VAN, L., CONVENT, B., BRIQUET, M., & GOFFEAU, A. (1977). Mitochondrial Heredity of Resistance to 3â(3,4âDichlorophenyl)â1,1âdimethylurea, an Inhibitor of Cytochrome b Oxidation, in Saccharomyces cerevisiae. European Journal of Biochemistry, 74(3), 521â531. Portico.

Authors 5

Anne‐Marie COLSON (first)
Luu THE VAN (additional)
Bernard CONVENT (additional)
Michel BRIQUET (additional)
André GOFFEAU (additional)

References 25 Referenced 42

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Dates

Type	When
Created	20 years, 6 months ago (March 3, 2005, 12:45 p.m.)
Deposited	1 year, 11 months ago (Oct. 1, 2023, 3:39 p.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 2:59 p.m.)
Issued	48 years, 5 months ago (April 1, 1977)
Published	48 years, 5 months ago (April 1, 1977)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	48 years, 5 months ago (April 1, 1977)

Funders 0

None

BibTeX

@article{COLSON_1977, title={Mitochondrial Heredity of Resistance to 3‐(3,4‐Dichlorophenyl)‐1,1‐dimethylurea, an Inhibitor of Cytochrome b Oxidation, in Saccharomyces cerevisiae}, volume={74}, ISSN={1432-1033}, url={http://dx.doi.org/10.1111/j.1432-1033.1977.tb11419.x}, DOI={10.1111/j.1432-1033.1977.tb11419.x}, number={3}, journal={European Journal of Biochemistry}, publisher={Wiley}, author={COLSON, Anne‐Marie and THE VAN, Luu and CONVENT, Bernard and BRIQUET, Michel and GOFFEAU, André}, year={1977}, month=apr, pages={521–531} }

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