DOI: 10.1111/j.1399-3011.1992.tb00305.x. Amino acid structure and “difficult sequences” in solid phase peptide synthesis

Amino acid structure and “difficult sequences” in solid phase peptide synthesis

10.1111/j.1399-3011.1992.tb00305.x

Crossref journal-article

Wiley

International Journal of Peptide and Protein Research (311)

Abstract

Deprotection peak profiles have been determined as a measure of internal aggregation during Fmoc‐polyamide continuous flow solid phase synthesis. The results have been correlated with amino‐acid structure and discussed in terms of minimising aggregation during synthesis.

Bibliography

BEDFORD, J., HYDE, C., JOHNSON, T., JUN, W., OWEN, D., QUIBELL, M., & SHEPPARD, R. C. (1992). Amino acid structure and âdifficult sequencesâ in solid phase peptide synthesis. International Journal of Peptide and Protein Research, 40(3â4), 300â307. Portico.

Authors 7

JOY BEDFORD (first)
CAROLYN HYDE (additional)
T. JOHNSON (additional)
WEN JUN (additional)
D. OWEN (additional)
M. QUIBELL (additional)
R.C. SHEPPARD (additional)

References 24 Referenced 105

{'key': 'e_1_2_1_2_2', 'first-page': '412', 'volume': '21', 'author': 'Merrifield R.B.', 'year': '1962', 'journal-title': 'Fed. Proc. Fed. Am. Soc. Exp. Biol.'} / Fed. Proc. Fed. Am. Soc. Exp. Biol. by Merrifield R.B. (1962)
{'key': 'e_1_2_1_3_2', 'first-page': '3', 'volume-title': 'The Peptides', 'author': 'Barany G.', 'year': '1979'} / The Peptides by Barany G. (1979)
{'key': 'e_1_2_1_4_2', 'first-page': '1', 'volume-title': 'Solid phase peptide synthesis; a practical approach', 'author': 'Atherton E.', 'year': '1989'} / Solid phase peptide synthesis; a practical approach by Atherton E. (1989)
{'key': 'e_1_2_1_5_2', 'first-page': '773', 'volume-title': 'Innovations and perspectives in solid phase synthesis', 'author': 'Narita M.', 'year': '1989'} / Innovations and perspectives in solid phase synthesis by Narita M. (1989)
{'key': 'e_1_2_1_6_2', 'first-page': '111', 'volume-title': 'Perspectives in peptide chemistry', 'author': 'Sheppard R.C.', 'year': '1972'} / Perspectives in peptide chemistry by Sheppard R.C. (1972)
10.1021/ja00855a053
10.1021/jo00944a033
{'key': 'e_1_2_1_9_2', 'first-page': '407', 'volume-title': 'Peptides, Structure and Function; Proceedings of the 9th American Peptide Symposium', 'author': 'Kent S.B.H.', 'year': '1985'} / Peptides, Structure and Function; Proceedings of the 9th American Peptide Symposium by Kent S.B.H. (1985)
Atherton E.&Sheppard R.C..Ibid pp.415–418.
10.1111/j.1399-3011.1984.tb02725.x
10.1021/ja00172a020
{'key': 'e_1_2_1_13_2', 'first-page': '151', 'volume-title': 'Proc. 20th European Peptide Symp', 'author': 'Nguyen O.', 'year': '1989'} / Proc. 20th European Peptide Symp by Nguyen O. (1989)
Flegel M.&Sheppard R.C.(1990)J. Chem. Soc. Chem. Commun.536–538. (10.1039/c39900000536)
Paper presented by R.B. Merrifield at the EUCHEM Conference onNew trends in peptide synthesis Port Camargue (France) 1988.
{'key': 'e_1_2_1_16_2', 'article-title': 'Proc. 2nd Int. Conf. Solid Phase Synthesis', 'author': 'Bedford J.', 'year': '1992', 'journal-title': 'Canterbury'} / Canterbury / Proc. 2nd Int. Conf. Solid Phase Synthesis by Bedford J. (1992)
Atherton E. Pinori M.&Sheppard R.C.(1985)J. Chem. Soc. Perkin Trans. I 2057–2064. (10.1039/P19850002057)
10.1111/j.1399-3011.1987.tb03377.x
10.1021/ja00011a023
Schön I. Colombo R.&Csehi A.(1983)J. Chem. Soc. Chem. Commun.505–507. (10.1039/C39830000505)
10.1021/bi00613a026
Atherton E. Woolley V.&SheppardR.C.(1980)J. Chem. Soc. Chem. Commun.970–971. (10.1039/C39800000970)
Johnson T.&Sheppard R.C.(1989) inMolecular Recognition: Chemical and Biochemical Problems Proc. Intl. Symposium(Roberts S.M.ed.) pp.123–133 Exeter .
10.1016/S0040-4020(01)86122-6
10.1039/p19880002895

Dates

Type	When
Created	15 years ago (Aug. 9, 2010, 7:20 p.m.)
Deposited	2 years ago (Aug. 30, 2023, 7:55 a.m.)
Indexed	1 week, 1 day ago (Aug. 29, 2025, 6:37 a.m.)
Issued	33 years ago (Sept. 1, 1992)
Published	33 years ago (Sept. 1, 1992)
Published Online	16 years, 7 months ago (Jan. 12, 2009)
Published Print	33 years ago (Sept. 1, 1992)

Funders 0

None

BibTeX

@article{BEDFORD_1992, title={Amino acid structure and “difficult sequences” in solid phase peptide synthesis}, volume={40}, ISSN={0367-8377}, url={http://dx.doi.org/10.1111/j.1399-3011.1992.tb00305.x}, DOI={10.1111/j.1399-3011.1992.tb00305.x}, number={3–4}, journal={International Journal of Peptide and Protein Research}, publisher={Wiley}, author={BEDFORD, JOY and HYDE, CAROLYN and JOHNSON, T. and JUN, WEN and OWEN, D. and QUIBELL, M. and SHEPPARD, R.C.}, year={1992}, month=sep, pages={300–307} }

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