DOI: 10.1111/j.1399-3011.1990.tb00955.x. Proposed solution structure of endothelin

Proposed solution structure of endothelin

10.1111/j.1399-3011.1990.tb00955.x

Crossref journal-article

Wiley

International Journal of Peptide and Protein Research (311)

Abstract

A model is proposed for the 3‐dimensional structure of endothelin, a potent vasoconstrictor and pressor peptide from vascular endothelium. The model is derived through protein structure prediction and circular dichroism studies, and is based on the atomic coordinates for the bee‐venom peptide apamin. The model derived shows the same turn‐helix motif as observed for apamin and mast‐cell degranulating peptide. On the basis of this model we suggest possible strategies for endothelin antagonist design, and note that this motif may be common in a number of peptides acting on channel proteins.

Bibliography

PERKINS, T. D. J., HIDER, R. C., & BARLOW, D. J. (1990). Proposed solution structure of endothelin. International Journal of Peptide and Protein Research, 36(2), 128â133. Portico.

Authors 3

T.D.J. PERKINS (first)
R. C. HIDER (additional)
D.J. BARLOW (additional)

References 26 Referenced 16

Dates

Type	When
Created	15 years ago (Aug. 9, 2010, 7:29 p.m.)
Deposited	1 year, 11 months ago (Sept. 26, 2023, 10:09 p.m.)
Indexed	1 year, 10 months ago (Oct. 27, 2023, 5:21 a.m.)
Issued	35 years, 1 month ago (Aug. 1, 1990)
Published	35 years, 1 month ago (Aug. 1, 1990)
Published Online	16 years, 7 months ago (Jan. 12, 2009)
Published Print	35 years, 1 month ago (Aug. 1, 1990)

Funders 0

None

BibTeX

@article{PERKINS_1990, title={Proposed solution structure of endothelin}, volume={36}, ISSN={0367-8377}, url={http://dx.doi.org/10.1111/j.1399-3011.1990.tb00955.x}, DOI={10.1111/j.1399-3011.1990.tb00955.x}, number={2}, journal={International Journal of Peptide and Protein Research}, publisher={Wiley}, author={PERKINS, T.D.J. and HIDER, R. C. and BARLOW, D.J.}, year={1990}, month=aug, pages={128–133} }

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