DOI: 10.1111/j.1399-0039.1998.tb03099.x. Phenotypical and functional characterization of <i>Herpesvirus saimiri</i>‐immortalized human major histocompatibility complex class ll‐deficient T lymphocytes

Phenotypical and functional characterization of Herpesvirus saimiri‐immortalized human major histocompatibility complex class ll‐deficient T lymphocytes

10.1111/j.1399-0039.1998.tb03099.x

Crossref journal-article

Wiley

Tissue Antigens (311)

Abstract

Abstract: CD8+ T lymphocytes from two unrelated cases of MHC class II deficiency were immortalized in vitro using Herpesvirus saimiri. In both cases, a lack of expression of surface MHC class II molecules was ascertained, whereas variable defects were shown for MHC class I, CD74 (invariant chain) and LAG‐3 (an MHC class II ligand). The functional analysis of both H. saimiri‐immortalized T‐cell lines revealed the existence of a proliferation impairment in response to anti‐CD3 but not to other surface or transmem‐brane stimuli. Further characterization of this functional defect indicated that it was not associated with impaired early activation events (like calcium flux) but, rather, with certain late events, like the induction of IL‐2. H. saimiri'‐immortalized T cells may be valuable in studying the biological role of MHC class II molecules in activated human T cells.

Bibliography

AlvarezâZapata, D., de Miguel Olalla, S., FontÃ¡n, G., Ferreira, A., GarcÃaâRodrÃguez, M. C., Madero, L., van den Elsen, P., & Regueiro, J. R. (1998). Phenotypical and functional characterization of Herpesvirus saimiriâimmortalized human major histocompatibility complex class llâdeficient T lymphocytes. Tissue Antigens, 51(3), 250â257. Portico.

Authors 8

D. Alvarez‐Zapata (first)
S. de Miguel Olalla (additional)
G. Fontán (additional)
A. Ferreira (additional)
M.C. García‐Rodríguez (additional)
L. Madero (additional)
P. van den Elsen (additional)
J.R. Regueiro (additional)

References 16 Referenced 11

10.1146/annurev.immunol.14.1.301
{'key': 'e_1_2_1_3_2', 'first-page': '141', 'article-title': 'Combined immunodeficiency with defective expression in MHC class II genes', 'volume': '1', 'author': 'Griscelli C.', 'year': '1989', 'journal-title': 'Immunodefic Rev'} / Immunodefic Rev / Combined immunodeficiency with defective expression in MHC class II genes by Griscelli C. (1989)
10.1016/0923-2494(91)90124-2
10.1016/0198-8859(93)90552-C
10.4049/jimmunol.149.1.65 / J Immunol / Signals delivered via MHC class II molecules synergize with signals delivered via TCR/ CD3 to cause proliferation and cytokine gene expression in T cells by Spertini F. (1992)
10.1002/eji.1830210119
10.1016/0167-5699(95)80087-5
10.1128/jvi.69.12.8114-8117.1995 / J Virol / Immortalization of human T cells expressing T‐cell receptor γδ by Herpesvirus saimiri by Yasukawa M. (1995)
10.1093/intimm/5.8.985
10.1084/jem.176.3.909
10.1073/pnas.89.7.3116
10.1084/jem.174.2.319
10.1002/eji.1830240727
10.1084/jem.176.2.327
vanEggermondMCJA PeijnenburgAACM GobinSJP.vanGraafeilandNG van denElsenP.The novel complementation group E in bare lymphocyte syndrome is characterized by a defect in CIITA regulation.Proceedings of the VIII meeting of the European Society for Immunodeficiencies (ESID) communication no. 32; Göteborg June 69 1996.
10.1016/S1074-7613(00)80347-7

Dates

Type	When
Created	15 years, 1 month ago (July 23, 2010, 7:08 p.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 10:48 p.m.)
Indexed	1 year, 10 months ago (Oct. 17, 2023, 8:19 p.m.)
Issued	27 years, 6 months ago (March 1, 1998)
Published	27 years, 6 months ago (March 1, 1998)
Published Online	16 years, 8 months ago (Dec. 11, 2008)
Published Print	27 years, 6 months ago (March 1, 1998)

Funders 0

None

BibTeX

@article{Alvarez_Zapata_1998, title={Phenotypical and functional characterization of Herpesvirus saimiri‐immortalized human major histocompatibility complex class ll‐deficient T lymphocytes}, volume={51}, ISSN={1399-0039}, url={http://dx.doi.org/10.1111/j.1399-0039.1998.tb03099.x}, DOI={10.1111/j.1399-0039.1998.tb03099.x}, number={3}, journal={Tissue Antigens}, publisher={Wiley}, author={Alvarez‐Zapata, D. and de Miguel Olalla, S. and Fontán, G. and Ferreira, A. and García‐Rodríguez, M.C. and Madero, L. and van den Elsen, P. and Regueiro, J.R.}, year={1998}, month=mar, pages={250–257} }

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