DOI: 10.1111/j.1399-0039.1985.tb00967.x. A human helper‐dependent influenza virus‐specific cytotoxic Tlymphocyte clone restricted by HLA‐DR2

A human helper‐dependent influenza virus‐specific cytotoxic Tlymphocyte clone restricted by HLA‐DR2

10.1111/j.1399-0039.1985.tb00967.x

Crossref journal-article

Wiley

Tissue Antigens (311)

Abstract

A human influenza A virus‐specific cytotoxic Tlymphocyte (CTL) clone is described that is restricted by a class II HLA‐antigen. Of a large panel of B‐lympho‐blastoid cell lines (B‐LCL) as target cells the clone lysed only infected cells sharing HLA‐DR2 with the donor of the clone. In cold target inhibition studies only infected cells bearing HLA‐DR2 could inhibit cytotoxicity. Infected PHA‐blasts that express less DR‐antigen than B‐LCL cells were lysed to a much lesser extent though they could be infected equally well. Trypan blue staining and postlabelling of the target cells showed that the clone indeed killed the target cells. The clone did not proliferate in response to infected irradiated autologous LCL cells and had the OKT3+4+8−DR+ phenotype. The possible significance of class II restricted CTL is discussed.

Bibliography

Fleischer, B. (1985). A human helperâdependent influenza virusâspecific cytotoxic Tlymphocyte clone restricted by HLAâDR2. Tissue Antigens, 26(4), 248â253. Portico.

Authors 1

Bernhard Fleischer (first)

References 21 Referenced 4

10.1007/BF00915971
10.4049/jimmunol.127.2.487 / J Immunol / T cell subpopulations required for the human cytotoxic T cell response to influenza virus‐ DR2‐RESTRICTED CTL 253 infected cells: evidence for T cell help by Biddison W. E. (1981)
10.1002/art.1780241106
{'key': 'e_1_2_1_5_1', 'first-page': '1', 'article-title': 'Lectin‐dependent cytolytic and cytolymic T helper clones and hybridomas', 'volume': '100', 'author': 'Fischer‐Lindahl K.', 'year': '1982', 'journal-title': 'Curr Top Microbiol Immunol'} / Curr Top Microbiol Immunol / Lectin‐dependent cytolytic and cytolymic T helper clones and hybridomas by Fischer‐Lindahl K. (1982)
10.4049/jimmunol.129.4.1731 / J Immunol / Cloned lines of human cytotoxic Tlymphocytes with secificity for influenza virus by Fleischer B. (1982)
10.1111/j.1399-0039.1983.tb00164.x
10.1038/308365a0
10.1016/0167-5699(83)90077-4
10.1111/j.1399-0039.1984.tb00028.x
10.1111/j.1365-3083.1980.tb00051.x
10.4049/jimmunol.133.2.754 / J Immunol / Measles virus‐specific T4+ human cytotoxic T cell clones are restricted by class II HLA‐antigens by Jacobson S. (1984)
10.4049/jimmunol.133.4.1966 / J Immunol / Antigen‐dependent regulation of IL‐2 receptors on cloned human cytotoxic Tlymphocytes by Kaplan D. R. (1984)
10.4049/jimmunol.129.2.844 / J Immunol / HLA‐restric‐tion of human secondary mumps virus‐specific cytotoxic Tlymphocytes by Kress H. G. (1982)
10.1007/BF00366130
10.1007/BF00199923
{'key': 'e_1_2_1_17_1', 'first-page': '195s', 'article-title': 'Influenza virus‐spedific cytotoxic Tlymphocytes recognize HLA molecules. Blocking with monoclonal antibodies', 'volume': '152', 'author': 'McMichael A. J.', 'year': '1980', 'journal-title': 'J Exp Med'} / J Exp Med / Influenza virus‐spedific cytotoxic Tlymphocytes recognize HLA molecules. Blocking with monoclonal antibodies by McMichael A. J. (1980)
{'key': 'e_1_2_1_18_1', 'volume-title': 'Proceedings of the First International Workshop on Monoclonal Antibodies to MHC Class II Antigens', 'author': 'Steel C. M.', 'year': '1984'} / Proceedings of the First International Workshop on Monoclonal Antibodies to MHC Class II Antigens by Steel C. M. (1984)
10.1002/eji.1830110905
10.1084/jem.156.6.1854
10.1007/BF00364294
10.4049/jimmunol.133.1.422 / J Immunol / Human cytotoxic Tlymphocyte clones directed against herpes simplex virus‐infected cells. I. Lysis restricted by HLA class II MB or DR antigens by Yasukawa M. (1984)

Dates

Type	When
Created	15 years, 1 month ago (July 23, 2010, 9:26 p.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 8:31 a.m.)
Indexed	1 year, 10 months ago (Oct. 22, 2023, 4:12 a.m.)
Issued	39 years, 10 months ago (Oct. 1, 1985)
Published	39 years, 10 months ago (Oct. 1, 1985)
Published Online	16 years, 8 months ago (Dec. 11, 2008)
Published Print	39 years, 10 months ago (Oct. 1, 1985)

Funders 0

None

BibTeX

@article{Fleischer_1985, title={A human helper‐dependent influenza virus‐specific cytotoxic Tlymphocyte clone restricted by HLA‐DR2}, volume={26}, ISSN={1399-0039}, url={http://dx.doi.org/10.1111/j.1399-0039.1985.tb00967.x}, DOI={10.1111/j.1399-0039.1985.tb00967.x}, number={4}, journal={Tissue Antigens}, publisher={Wiley}, author={Fleischer, Bernhard}, year={1985}, month=oct, pages={248–253} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        10,
        22
      ]
    ],
    "date-time": "2023-10-22T08:12:42Z",
    "timestamp": 1697962362588
  },
  "reference-count": 21,
  "publisher": "Wiley",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            12,
            11
          ]
        ],
        "date-time": "2008-12-11T00:00:00Z",
        "timestamp": 1228953600000
      },
      "content-version": "vor",
      "delay-in-days": 8472,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1985,
        10
      ]
    ]
  },
  "abstract": "<jats:p>A human influenza A virus\u2010specific cytotoxic Tlymphocyte (CTL) clone is described that is restricted by a class II HLA\u2010antigen. Of a large panel of B\u2010lympho\u2010blastoid cell lines (B\u2010LCL) as target cells the clone lysed only infected cells sharing HLA\u2010DR2 with the donor of the clone. In cold target inhibition studies only infected cells bearing HLA\u2010DR2 could inhibit cytotoxicity. Infected PHA\u2010blasts that express less DR\u2010antigen than B\u2010LCL cells were lysed to a much lesser extent though they could be infected equally well. Trypan blue staining and postlabelling of the target cells showed that the clone indeed killed the target cells. The clone did not proliferate in response to infected irradiated autologous LCL cells and had the OKT3<jats:sup>+</jats:sup>4<jats:sup>+</jats:sup>8<jats:sup>\u2212</jats:sup>DR<jats:sup>+</jats:sup> phenotype. The possible significance of class II restricted CTL is discussed.</jats:p>",
  "DOI": "10.1111/j.1399-0039.1985.tb00967.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        7,
        24
      ]
    ],
    "date-time": "2010-07-24T01:26:30Z",
    "timestamp": 1279934790000
  },
  "page": "248-253",
  "source": "Crossref",
  "is-referenced-by-count": 4,
  "title": "A human helper\u2010dependent influenza virus\u2010specific cytotoxic Tlymphocyte clone restricted by HLA\u2010DR2",
  "prefix": "10.1111",
  "volume": "26",
  "author": [
    {
      "given": "Bernhard",
      "family": "Fleischer",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2008,
        12,
        11
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00915971"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.4049/jimmunol.127.2.487",
      "article-title": "T cell subpopulations required for the human cytotoxic T cell response to influenza virus\u2010 DR2\u2010RESTRICTED CTL 253 infected cells: evidence for T cell help",
      "volume": "127",
      "author": "Biddison W. E.",
      "year": "1981",
      "journal-title": "J Immunol"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/art.1780241106"
    },
    {
      "key": "e_1_2_1_5_1",
      "first-page": "1",
      "article-title": "Lectin\u2010dependent cytolytic and cytolymic T helper clones and hybridomas",
      "volume": "100",
      "author": "Fischer\u2010Lindahl K.",
      "year": "1982",
      "journal-title": "Curr Top Microbiol Immunol"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "1731",
      "DOI": "10.4049/jimmunol.129.4.1731",
      "article-title": "Cloned lines of human cytotoxic Tlymphocytes with secificity for influenza virus",
      "volume": "129",
      "author": "Fleischer B.",
      "year": "1982",
      "journal-title": "J Immunol"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1399-0039.1983.tb00164.x"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/308365a0"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0167-5699(83)90077-4"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1399-0039.1984.tb00028.x"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-3083.1980.tb00051.x"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "754",
      "DOI": "10.4049/jimmunol.133.2.754",
      "article-title": "Measles virus\u2010specific T4+ human cytotoxic T cell clones are restricted by class II HLA\u2010antigens",
      "volume": "132",
      "author": "Jacobson S.",
      "year": "1984",
      "journal-title": "J Immunol"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "1966",
      "DOI": "10.4049/jimmunol.133.4.1966",
      "article-title": "Antigen\u2010dependent regulation of IL\u20102 receptors on cloned human cytotoxic Tlymphocytes",
      "volume": "133",
      "author": "Kaplan D. R.",
      "year": "1984",
      "journal-title": "J Immunol"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "844",
      "DOI": "10.4049/jimmunol.129.2.844",
      "article-title": "HLA\u2010restric\u2010tion of human secondary mumps virus\u2010specific cytotoxic Tlymphocytes",
      "volume": "129",
      "author": "Kress H. G.",
      "year": "1982",
      "journal-title": "J Immunol"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00366130"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00199923"
    },
    {
      "key": "e_1_2_1_17_1",
      "first-page": "195s",
      "article-title": "Influenza virus\u2010spedific cytotoxic Tlymphocytes recognize HLA molecules. Blocking with monoclonal antibodies",
      "volume": "152",
      "author": "McMichael A. J.",
      "year": "1980",
      "journal-title": "J Exp Med"
    },
    {
      "key": "e_1_2_1_18_1",
      "volume-title": "Proceedings of the First International Workshop on Monoclonal Antibodies to MHC Class II Antigens",
      "author": "Steel C. M.",
      "year": "1984"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/eji.1830110905"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1084/jem.156.6.1854"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00364294"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "422",
      "DOI": "10.4049/jimmunol.133.1.422",
      "article-title": "Human cytotoxic Tlymphocyte clones directed against herpes simplex virus\u2010infected cells. I. Lysis restricted by HLA class II MB or DR antigens",
      "volume": "133",
      "author": "Yasukawa M.",
      "year": "1984",
      "journal-title": "J Immunol"
    }
  ],
  "container-title": "Tissue Antigens",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0039.1985.tb00967.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.1985.tb00967.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        21
      ]
    ],
    "date-time": "2023-10-21T12:31:08Z",
    "timestamp": 1697891468000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1399-0039.1985.tb00967.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1985,
        10
      ]
    ]
  },
  "references-count": 21,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1985,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1399-0039.1985.tb00967.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1399-0039.1985.tb00967.x",
  "relation": {},
  "ISSN": [
    "0001-2815",
    "1399-0039"
  ],
  "subject": [],
  "container-title-short": "Tissue Antigens",
  "published": {
    "date-parts": [
      [
        1985,
        10
      ]
    ]
  }
}