DOI: 10.1111/j.1399-0039.1979.tb00875.x. A Monoclonal Mouse Anti‐Rat Ia Antibody which Cross Reacts with a Human HLA

A Monoclonal Mouse Anti‐Rat Ia Antibody which Cross Reacts with a Human HLA—DRw Determinant

10.1111/j.1399-0039.1979.tb00875.x

Crossref journal-article

Wiley

Tissue Antigens (311)

Abstract

A mouse monoclonal antibody, called MRC OX 3, which detects a polymorphic Ia determinant in the rat and cross reacts with an Ia determinant coded for by the I‐A subregion in the mouse, detects a polymorphic determinant on human B cell lines. MRC OX 3 antibody binds to human B cell lines which express HLA‐DRw specificities DRw 1, DRw2 and DRw6 but does not bind to those cells which only express other HLA‐DRw specificities. No significant binding of MRC OX 3 antibody to either normal or mitogen stimulated human peripheral blood leukocytes, some of which are typed as HLA‐DRw1, DRw2 or DRw6, could be detected. The binding of MRC OX 3 antibody to a human B cell line could be completely inhibited by pre‐absorbing the antibody with purified rat Ia antigen.

Bibliography

McMaster, W. R., Winearls, B. C., & Parham, P. (1979). A Monoclonal Mouse AntiâRat Ia Antibody which Cross Reacts with a Human HLAâDRw Determinant. Tissue Antigens, 14(5), 453â458. Portico.

Authors 3

W. Robert McMaster (first)
Beryl C. Winearls (additional)
Peter Parham (additional)

References 15 Referenced 27

10.1073/pnas.75.8.3953
10.1093/oxfordjournals.bmb.a071503 / Brit. Med. Bull. / Ia antigens. Definition of the HLA‐DRw specificities by Bodmer J. G. (1978)
Brodsky F. M. Parham P.&Bodmer W. F.(1979)Monoclonal antibodies against HLA—DRw determinants.Tissue Antigensin preparation. (10.1111/j.1399-0039.1980.tb00285.x)
10.1084/jem.149.4.981
{'key': 'e_1_2_1_6_1', 'first-page': '236', 'article-title': 'Structural and serological properties of murine Ia alloantigens', 'volume': '30', 'author': 'Cullen S. E.', 'year': '1976', 'journal-title': 'Transplant, Rev.'} / Transplant, Rev. / Structural and serological properties of murine Ia alloantigens by Cullen S. E. (1976)
10.1111/j.1399-0039.1972.tb00122.x
10.1084/jem.148.4.925
10.1002/eji.1830081013
10.1002/eji.1830090603
10.1111/j.1399-0039.1974.tb00248.x
{'key': 'e_1_2_1_12_1', 'first-page': '637', 'article-title': 'Sharing of Ia antigens beteen species. II Molecular localization of shared Ia determinants implies the existence of more than one I sublocus of the rat MHC', 'volume': '121', 'author': 'Shinohara N.', 'year': '1978', 'journal-title': 'J. Immunol.'} / J. Immunol. / Sharing of Ia antigens beteen species. II Molecular localization of shared Ia determinants implies the existence of more than one I sublocus of the rat MHC by Shinohara N. (1978)
10.1101/SQB.1977.041.01.044
10.1101/SQB.1977.041.01.045
10.1038/268213a0
10.1016/0092-8674(77)90266-5

Dates

Type	When
Created	15 years, 1 month ago (July 23, 2010, 8:32 p.m.)
Deposited	1 year, 5 months ago (March 28, 2024, 1:46 p.m.)
Indexed	1 year, 4 months ago (April 21, 2024, 1:19 p.m.)
Issued	45 years, 10 months ago (Nov. 1, 1979)
Published	45 years, 10 months ago (Nov. 1, 1979)
Published Online	16 years, 8 months ago (Dec. 11, 2008)
Published Print	45 years, 10 months ago (Nov. 1, 1979)

Funders 0

None

BibTeX

@article{McMaster_1979, title={A Monoclonal Mouse Anti‐Rat Ia Antibody which Cross Reacts with a Human HLA—DRw Determinant}, volume={14}, ISSN={1399-0039}, url={http://dx.doi.org/10.1111/j.1399-0039.1979.tb00875.x}, DOI={10.1111/j.1399-0039.1979.tb00875.x}, number={5}, journal={Tissue Antigens}, publisher={Wiley}, author={McMaster, W. Robert and Winearls, Beryl C. and Parham, Peter}, year={1979}, month=nov, pages={453–458} }

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