Recombinant allergens
10.1111/j.1398-9995.1998.tb03930.x
Crossref journal-article
Wiley
Allergy (311)
Abstract

A great variety of recombinant plant, mite, mold, mammal, and insect allergens have been expressed in heterologous hosts (e.g., Escherichia coli), their cDNA being used as a template. The number of biologically active recombinant allergens available for experimental, diagnostic, and therapeutic purposes is increasing tremendously. Recombinant allergens have proven to be valuable tools to investigate T‐cell and B‐cell recognition of allergens as well as to study mechanisms of specific IgE regulation. The immunologic equivalence of many relevant recombinant allergens with their natural counterparts has been demonstrated, and the three‐dimensional structures of several recombinant allergens have been described recently. As a result of extensive cross‐reactivities among the relevant allergens, it appears that the number of epitopes needed for diagnosis and specific immunotherapy is less diverse than originally anticipated and might be soon covered by recombinant molecules. Recombinant allergens have been used for successful in vitro, as well as in vivo, allergy diagnosis, and work is in progress to produce recombinant allergen derivatives with reduced anaphylactic potential to improve current forms of immunotherapy.

Bibliography

Valenta, R., Vrtala, S., Laffer, S., Spitzauer, S., & Kraft, D. (1998). Recombinant allergens. Allergy, 53(6), 552–561. Portico.

Authors 5
  1. R. Valenta (first)
  2. S. Vrtala (additional)
  3. S. Laffer (additional)
  4. S. Spitzauer (additional)
  5. D. Kraft (additional)
References 92 Referenced 73
  1. 10.1111/j.1398-9995.1995.tb01167.x
  2. 10.1016/0952-7915(95)80043-3
  3. 10.1038/icb.1996.26
  4. {'key': 'e_1_2_1_5_2', 'first-page': '54', 'article-title': 'In vivo and in vitro use of recombinant allergens', 'volume': '6', 'author': 'Bousquet J', 'year': '1994', 'journal-title': 'Allergy Clin Immunol News'} / Allergy Clin Immunol News / In vivo and in vitro use of recombinant allergens by Bousquet J (1994)
  5. {'key': 'e_1_2_1_6_2', 'first-page': '53', 'article-title': 'The future of immunotherapy: therapeutic vaccines', 'author': 'Valenta R', 'year': '1998', 'journal-title': 'Allergy'} / Allergy / The future of immunotherapy: therapeutic vaccines by Valenta R (1998)
  6. 10.1111/j.1398-9995.1989.tb02230.x
  7. {'key': 'e_1_2_1_8_2', 'first-page': '57', 'volume-title': 'Epitopes of atopic allergens', 'author': 'Breitenbach M', 'year': '1990'} / Epitopes of atopic allergens by Breitenbach M (1990)
  8. 10.1111/j.1432-1033.1993.tb17669.x
  9. 10.1074/jbc.270.6.2607
  10. 10.1084/jem.183.2.599
  11. 10.1159/000234643
  12. 10.1002/j.1460-2075.1989.tb03597.x
  13. 10.1016/0076-6879(90)85008-C
  14. 10.1016/0091-6749(91)90245-J
  15. 10.1159/000236135
  16. 10.4049/jimmunol.150.3.1047 / J Immunol / Identification of multiple T‐cell epitopes on Bet v 1, the major birch pollen allergen using specific T cell clones and overlapping peptides by Ebner C (1993)
  17. 10.1016/0091-6749(93)90300-5
  18. {'key': 'e_1_2_1_19_2', 'first-page': '158', 'article-title': 'Induction of IgE antibodies in mice with recombinant grass pollen antigens', 'volume': '76', 'author': 'Sehon AH', 'year': '1992', 'journal-title': 'Immunology'} / Immunology / Induction of IgE antibodies in mice with recombinant grass pollen antigens by Sehon AH (1992)
  19. 10.1016/S0091-6749(96)70287-7
  20. 10.1016/S0091-6749(96)80007-8
  21. 10.1016/0091-6749(94)90227-5
  22. 10.1016/S0091-6749(95)70059-5
  23. 10.1111/j.1365-2222.1996.tb00056.x
  24. 10.1016/S0091-6749(96)70264-6
  25. 10.1159/000236805
  26. 10.1016/S0021-9258(20)80615-2 / J Biol Chem / Cloning, expression, and immunological characterization of recombinant Lolium perenne allergen Lol p 2 by Sidoli A (1993)
  27. 10.1016/0091-6749(94)90383-2
  28. 10.1002/eji.1830240925
  29. 10.1016/S0091-6749(95)70237-7
  30. 10.4049/jimmunol.154.4.1932 / J Immunol / Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients by Ebner C (1995)
  31. {'key': 'e_1_2_1_32_2', 'first-page': '351', 'article-title': 'Peptide specificity and HLA restriction do not dictate lymphokine production by allergen‐specific T‐lymphocyte clones', 'volume': '82', 'author': 'Vanneerven RJ', 'year': '1994', 'journal-title': 'Immunology'} / Immunology / Peptide specificity and HLA restriction do not dictate lymphokine production by allergen‐specific T‐lymphocyte clones by Vanneerven RJ (1994)
  32. 10.1016/0952-7915(93)90114-8
  33. {'key': 'e_1_2_1_34_2', 'first-page': '327', 'article-title': 'Allergen‐specific immunotherapy: a role for T‐cell anergy', 'volume': '71', 'author': 'Sheffer AL.', 'year': '1993', 'journal-title': 'Ann Allergy'} / Ann Allergy / Allergen‐specific immunotherapy: a role for T‐cell anergy by Sheffer AL. (1993)
  34. 10.1016/0952-7915(94)90003-5
  35. 10.1073/pnas.90.16.7608
  36. 10.1084/jem.178.5.1783
  37. 10.1016/S0021-9258(18)46931-1 / J Biol Chem / Isolation of an immunodominant IgE hapten from an expression cDNA library by Ball T (1994)
  38. 10.4049/jimmunol.147.11.3768 / J Immunol / IgE and IgG binding of peptides expressed from fragments of cDNA encoding the major house dust mite allergen Der p I by Greene WK (1991)
  39. 10.1016/0161-5890(94)00127-M
  40. 10.1016/S0969-2126(97)00164-0
  41. 10.1172/JCI119330
  42. 10.1038/nsb1296-1040
  43. 10.4049/jimmunol.140.12.4193 / J Immunol / IL‐4 is an essential factor for the IgE‐synthesis induced in vitro by human T‐cell clones and their supernatants by Prete GF (1988)
  44. 10.4049/jimmunol.141.4.1218 / J Immunol / IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL‐4 and suppressed by IFN‐γ by Pene J (1988)
  45. 10.1016/S0952-7915(05)80003-2
  46. 10.1038/362248a0
  47. 10.1111/1523-1747.ep12371750
  48. 10.1016/S0091-6749(95)70010-2
  49. 10.1111/j.1365-2222.1995.tb00031.x
  50. 10.1126/science.1857985
  51. 10.1084/jem.175.2.377
  52. 10.1016/0091-6749(92)90465-E
  53. 10.1016/S0091-6749(95)70096-X
  54. 10.1016/S0091-6749(96)80062-5
  55. {'key': 'e_1_2_1_56_2', 'first-page': '1047', 'article-title': 'Edna cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl p 5 allergen', 'volume': '150', 'author': 'Vrtala S', 'year': '1993', 'journal-title': 'J Immunol'} / J Immunol / Edna cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl p 5 allergen by Vrtala S (1993)
  56. 10.1016/0091-6749(94)90075-2
  57. 10.1016/0091-6749(94)90176-7
  58. 10.1016/0161-5890(95)00152-2
  59. 10.1016/S0091-6749(97)70306-3
  60. 10.1021/bi00152a003
  61. 10.1074/jbc.271.44.27193
  62. 10.1016/S0969-2126(97)00163-9
  63. 10.1159/000237520
  64. 10.1074/jbc.271.18.10967
  65. 10.1007/978-1-4615-5855-2_25
  66. 10.1016/S0091-6749(96)70099-4
  67. 10.1111/j.1398-9995.1996.tb04498.x
  68. 10.1016/S0140-6736(00)78276-6
  69. {'key': 'e_1_2_1_70_2', 'first-page': '44', 'article-title': 'Allergen immunotherapy: therapeutic vaccines for allergic diseases. WHO position paper', 'volume': '53', 'author': 'Bousquet J', 'year': '1998', 'journal-title': 'Allergy'} / Allergy / Allergen immunotherapy: therapeutic vaccines for allergic diseases. WHO position paper by Bousquet J (1998)
  70. 10.1111/j.1398-9995.1988.tb00431.x
  71. 10.1084/jem.62.6.733
  72. 10.4049/jimmunol.38.1.25 / J Immunol / Immunological studies of pollinosis. I. The presence of 2 antibodies related to the same pollen‐antigen in the serum of treated hay fever patients by Loveless MH. (1940)
  73. 10.4049/jimmunol.101.2.317 / J Immunol / A quantitative in vitro study of the chromatographic distribution and immunoglobulin characteristics of human blocking antibody by Liehtenstein LM (1968)
  74. 10.4049/jimmunol.130.2.722 / J Immunol / Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4‐restricted response by Aalberse RC (1983)
  75. 10.1111/j.1398-9995.1990.tb01092.x
  76. 10.1016/S0091-6749(96)80156-4
  77. 10.1111/j.1365-2222.1996.tb00055.x
  78. 10.1016/S0091-6749(96)70309-3
  79. 10.4049/jimmunol.157.2.956 / J Immunol / Human monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1 by Visco Y (1996)
  80. 10.1038/348552a0
  81. 10.1073/pnas.88.18.7978
  82. 10.1038/349293a0
  83. 10.1073/pnas.89.8.3576
  84. 10.1084/jem.178.6.2123 / J Exp Med / Allergen immunotherapy decreases interleukin‐4 production in CD4+ T cells from allergic individuals by Secrist H (1993)
  85. 10.1172/JCI118963
  86. 10.4049/jimmunol.154.8.4187 / J Immunol / Bee venom immunotherapy results in decrease of IL‐4 and IL‐5 and increase of IFN‐γ secretion in specific allergen‐stimulated T cell cultures by Jutel M (1995)
  87. 10.1111/j.1365-2222.1995.tb00025.x
  88. 10.1016/0161-5890(95)00150-6
  89. 10.1038/nbt0897-754
  90. 10.1159/000237553
  91. 10.1073/pnas.93.10.5141
  92. 10.1038/nm0596-540
Dates
Type When
Created 18 years, 3 months ago (May 13, 2007, 8:32 p.m.)
Deposited 1 year, 11 months ago (Sept. 27, 2023, 10:40 a.m.)
Indexed 1 year, 9 months ago (Oct. 29, 2023, 1:58 p.m.)
Issued 27 years, 2 months ago (June 1, 1998)
Published 27 years, 2 months ago (June 1, 1998)
Published Online 18 years, 4 months ago (April 29, 2007)
Published Print 27 years, 2 months ago (June 1, 1998)
Funders 0

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@article{Valenta_1998, title={Recombinant allergens}, volume={53}, ISSN={1398-9995}, url={http://dx.doi.org/10.1111/j.1398-9995.1998.tb03930.x}, DOI={10.1111/j.1398-9995.1998.tb03930.x}, number={6}, journal={Allergy}, publisher={Wiley}, author={Valenta, R. and Vrtala, S. and Laffer, S. and Spitzauer, S. and Kraft, D.}, year={1998}, month=jun, pages={552–561} }