DOI: 10.1111/j.1398-9219.2004.00186.x. Predicting Function from Structure: 3D Structure Studies of the Mammalian Golgi Complex

Predicting Function from Structure: 3D Structure Studies of the Mammalian Golgi Complex

10.1111/j.1398-9219.2004.00186.x

Crossref journal-article

Wiley

Traffic (311)

Abstract

3D electron tomography studies of the structure of the mammalian Golgi complex have led to four functional predictions (1). The sorting and exit site from the Golgi comprises two or three distinct trans‐cisternae (2). The docking of vesicular–tubular clusters at the cis‐face and the fragmentation of trans‐cisternae are coordinated (3). The mechanisms of transport through, and exit from, the Golgi vary with physiological state, and in different cells and tissues (4). Specialized trans‐ER functions in the delivery of ceramide to sphingomyelin synthase in the trans‐Golgi membrane, for the regulated sorting via sphingolipid‐cholesterol‐rich domains. These structure‐based predictions can now be tested using a variety of powerful cell and molecular tools.

Bibliography

Mogelsvang, S., Marsh, B. J., Ladinsky, M. S., & Howell, K. E. (2004). Predicting Function from Structure: 3D Structure Studies of the Mammalian Golgi Complex. Traffic, 5(5), 338â345. Portico.

Authors 4

Soren Mogelsvang (first)
Brad J. Marsh (additional)
Mark S. Ladinsky (additional)
Kathryn E. Howell (additional)

References 58 Referenced 138

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Dates

Type	When
Created	21 years, 4 months ago (April 13, 2004, 5:50 a.m.)
Deposited	1 year, 10 months ago (Oct. 10, 2023, 4:07 p.m.)
Indexed	3 months, 4 weeks ago (April 23, 2025, 8:49 p.m.)
Issued	21 years, 4 months ago (April 13, 2004)
Published	21 years, 4 months ago (April 13, 2004)
Published Online	21 years, 4 months ago (April 13, 2004)
Published Print	21 years, 3 months ago (May 1, 2004)

Funders 0

None

BibTeX

@article{Mogelsvang_2004, title={Predicting Function from Structure: 3D Structure Studies of the Mammalian Golgi Complex}, volume={5}, ISSN={1600-0854}, url={http://dx.doi.org/10.1111/j.1398-9219.2004.00186.x}, DOI={10.1111/j.1398-9219.2004.00186.x}, number={5}, journal={Traffic}, publisher={Wiley}, author={Mogelsvang, Soren and Marsh, Brad J. and Ladinsky, Mark S. and Howell, Kathryn E.}, year={2004}, month=apr, pages={338–345} }

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