DOI: 10.1111/j.1365-3083.1995.tb03528.x. Enhancement of Infectivity of a Non‐Syncytium Inducing HIV‐1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIV‐1

Enhancement of Infectivity of a Non‐Syncytium Inducing HIV‐1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIV‐1

10.1111/j.1365-3083.1995.tb03528.x

Crossref journal-article

Wiley

Scandinavian Journal of Immunology (311)

Abstract

Enhancement of virus infectivity after sCD4 treatment has been documented for SIVagm and HIV‐2. It has been suggested that a similar phenomenon may play a role in HIV‐1 infection. In the present study we have analysed biological activities of virus neutralizing polyclonal and monoclonal human antibodies and of sCD4, towards HIV‐1 chimeras with envelope proteins derived from one donor, which display different biological phenotypes. The antibodies, which recognize the V3 and/or the CD4 binding domains of the glycoproteins of these viruses and also sCD4 showed different levels of virus neutralizing activity toward the syncytium inducing HIV‐1 strains. In contrast, they all dramatically enhanced the infectivity of an HIV‐1 chimera with an envelope glycoprotein displaying the non‐syncytium‐inducing phenotype. Given the relatively conserved nature of non‐syncytium‐inducing HIV‐1 surface glycoproteins early after infection, these data suggest a major role for antibody mediated enhancement of virus infectivity in the early pathogenesis of HIV‐1 infection.

Bibliography

SCHUTTEN, M., ANDEWEG, A. C., BOSCH, M. L., & OSTERHAUS, A. D. M. E. (1995). Enhancement of Infectivity of a NonâSyncytium Inducing HIVâ1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIVâ1. Scandinavian Journal of Immunology, 41(1), 18â22. Portico.

Authors 4

M. SCHUTTEN (first)
A. C. ANDEWEG (additional)
M. L. BOSCH (additional)
A. D. M. E. OSTERHAUS (additional)

References 24 Referenced 60

{'key': 'e_1_2_1_2_2', 'first-page': '196', 'article-title': 'Evaluation of monoclonal antibodies to HIV‐1 envelope by neutralization and binding assays: an international collaboration', 'volume': '8', 'author': "D'Souza MP", 'year': '1994', 'journal-title': 'AIDS'} / AIDS / Evaluation of monoclonal antibodies to HIV‐1 envelope by neutralization and binding assays: an international collaboration by D'Souza MP (1994)
10.1126/science.8356453
10.1128/jvi.67.6.3345-3356.1993 / J Virol / Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection by Zhang LQ (1993)
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{'key': 'e_1_2_1_15_2', 'first-page': '5657', 'article-title': 'Monoclonal antibody and enzymatic profiles of human malignant T‐lymphoid cells and derived cell lines', 'volume': '44', 'author': 'Smith SD', 'year': '1984', 'journal-title': 'Cancer Res'} / Cancer Res / Monoclonal antibody and enzymatic profiles of human malignant T‐lymphoid cells and derived cell lines by Smith SD (1984)
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10.1128/jvi.64.11.5301-5305.1990 / J Virol / Antibodies to the primary immunodominant domain of human immunodeficiency virus type 1 (HIV‐1) glycoprotein gp41 enhance HIV‐1 infection in vitro by Robinson WE (1990)
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10.1128/jvi.67.12.7383-7393.1993 / J Virol / Conformational changes induced in the envelope glycoproleins of the human and simian immunodeficiency viruses by soluble receptor binding by Sattentau QJ (1993)

Dates

Type	When
Created	19 years, 1 month ago (June 30, 2006, 11:17 p.m.)
Deposited	1 year, 10 months ago (Sept. 28, 2023, 9:27 a.m.)
Indexed	4 months, 3 weeks ago (April 4, 2025, 6:42 p.m.)
Issued	30 years, 7 months ago (Jan. 1, 1995)
Published	30 years, 7 months ago (Jan. 1, 1995)
Published Online	19 years, 1 month ago (June 29, 2006)
Published Print	30 years, 7 months ago (Jan. 1, 1995)

Funders 0

None

BibTeX

@article{SCHUTTEN_1995, title={Enhancement of Infectivity of a Non‐Syncytium Inducing HIV‐1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIV‐1}, volume={41}, ISSN={1365-3083}, url={http://dx.doi.org/10.1111/j.1365-3083.1995.tb03528.x}, DOI={10.1111/j.1365-3083.1995.tb03528.x}, number={1}, journal={Scandinavian Journal of Immunology}, publisher={Wiley}, author={SCHUTTEN, M. and ANDEWEG, A. C. and BOSCH, M. L. and OSTERHAUS, A. D. M. E.}, year={1995}, month=jan, pages={18–22} }

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