DOI: 10.1111/j.1365-3083.1979.tb02703.x. Influence of Thymus Genotype on Acquisition of Responsiveness in Delayed‐type Hypersensitivity

Influence of Thymus Genotype on Acquisition of Responsiveness in Delayed‐type Hypersensitivity

10.1111/j.1365-3083.1979.tb02703.x

Crossref journal-article

Wiley

Scandinavian Journal of Immunology (311)

Abstract

Antigen‐pulsed macrophages (Mph) could sensitize syngeneic mice for delayed‐type hypersensitivity (DTH) and also elicit sensitivity from mice sensitized to antigen in adjuvant provided these were syngeneic or semi‐allogeneic to the strain providing the Mph. Sensitivity could not be elicited with antigen‐pulsed allogeneic Mph. Antigen‐pulsed Mph from low‐responder (LR) strains could not sensitize LR mice nor F1 hybrids between responder (R) and LR strains. Normal F1 mice could he sensitized to respond to antigen presented on Mph of either parental type (i.e. P1 or P2): if, however, they were sensitized to antigen on P1 Mph. DTH transfer was restricted to naive P1 mice, not to P2 (restriction imposed by priming). F1 T cells derived from stem cells differentiating in a P1 thymus graft could he sensitized but could transfer sensitivity only to naive P1 mice, not to P2 (restriction imposed in thymus). When an antigen under Ir gene control was used, LR derived T cells differentiating in an (R×LR)F1 thymus could be sensitized but only if antigen was presented on (R×LR)F1 Mph not on LR Mph. Totally allogeneic chimaeras could be sensitized but only if given antigen in association with the appropriate Mph. These findings suggest that restriction of T cell activities can be imposed as a result of priming in some cases and as a result of differentiation within the thymus in others. LR strains appear to have a lesion at the level of antigen presentation by Mph; whether they also have a defect at the level of generation of T cell repertoire cannot he determined from the present investigations.

Bibliography

MILLER, J. F. A. P., GAMBLE, J., MOTTRAM, P., & SMITH, F. I. (1979). Influence of Thymus Genotype on Acquisition of Responsiveness in Delayedâtype Hypersensitivity. Scandinavian Journal of Immunology, 9(1), 29â38. Portico.

Authors 4

J. F. A. P. MILLER (first)
J. GAMBLE (additional)
P. MOTTRAM (additional)
F. I. SMITH (additional)

References 25 Referenced 32

10.1038/269417a0
{'key': 'e_1_2_1_3_2', 'first-page': '89', 'article-title': 'Specificity of virus immune effector T cells for H‐2K or H‐2D compatible interactions: implications for H antigen diversity', 'volume': '29', 'author': 'Doherty P.C.', 'year': '1976', 'journal-title': 'Transplant. Rev.'} / Transplant. Rev. / Specificity of virus immune effector T cells for H‐2K or H‐2D compatible interactions: implications for H antigen diversity by Doherty P.C. (1976)
10.1097/00007890-196509000-00006
10.4049/jimmunol.111.6.1621 / J. Immunol. / Mapping the H‐2 linked genes governing, respectively, the immune responses to a glutamic acid‐alanine‐tyrosine copolymer and to limiting doses of ovalbumin by Dunham E.K. (1973)
10.1084/jem.148.1.84
10.1111/j.1600-065X.1978.tb00259.x
{'key': 'e_1_2_1_8_2', 'article-title': 'Influence of the major histocompatibility complex on T cell activation', 'volume': '29', 'author': 'Miller J.F.A.P.', 'year': '1978', 'journal-title': 'Adv. Cancer Res.'} / Adv. Cancer Res. / Influence of the major histocompatibility complex on T cell activation by Miller J.F.A.P. (1978)
10.1084/jem.134.1.66
10.1111/j.1365-3083.1977.tb02150.x
10.1159/000231450
10.1073/pnas.72.12.5095
10.1084/jem.145.6.1623
10.1084/jem.146.6.1827
10.1084/jem.147.4.1159
10.1084/jem.147.6.1838
10.1111/j.1600-065X.1978.tb00260.x
10.1111/j.1600-065X.1978.tb00406.x
Vadas M.A.Cellular and genetic studies of delayed hypersensitivity in mice.Ph.D. thesis University of Melbourne 1976.
10.1159/000231449
10.1007/BF01575653
10.1073/pnas.75.5.2439
10.1002/eji.1830080510
10.1038/248701a0
10.1084/jem.147.3.882
10.1084/jem.147.3.897

Dates

Type	When
Created	19 years, 2 months ago (June 30, 2006, 9:16 a.m.)
Deposited	1 year, 9 months ago (Nov. 10, 2023, 6:51 p.m.)
Indexed	1 year, 7 months ago (Jan. 14, 2024, 11:21 a.m.)
Issued	46 years, 8 months ago (Jan. 1, 1979)
Published	46 years, 8 months ago (Jan. 1, 1979)
Published Online	19 years, 2 months ago (June 29, 2006)
Published Print	46 years, 8 months ago (Jan. 1, 1979)

Funders 0

None

BibTeX

@article{MILLER_1979, title={Influence of Thymus Genotype on Acquisition of Responsiveness in Delayed‐type Hypersensitivity}, volume={9}, ISSN={1365-3083}, url={http://dx.doi.org/10.1111/j.1365-3083.1979.tb02703.x}, DOI={10.1111/j.1365-3083.1979.tb02703.x}, number={1}, journal={Scandinavian Journal of Immunology}, publisher={Wiley}, author={MILLER, J. F. A. P. and GAMBLE, J. and MOTTRAM, P. and SMITH, F. I.}, year={1979}, month=jan, pages={29–38} }

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