DOI: 10.1111/j.1365-2990.1995.tb01022.x. Oxidative stress in Parkinson's disease

10.1111/j.1365-2990.1995.tb01022.x

Crossref journal-article

Wiley

Neuropathology and Applied Neurobiology (311)

Abstract

Oxidative damage and mitochondrial dysfunction are now considered to be important events in the cause of dopaminergic cell death in Parkinson's disease (PD). It is not known whether these biochemical abnormalities represent primary causes of PD or whether they are the end result of a series of reactions precipitated by environmental and genetic factors. Both oxidative damage and complex 1 deficiency are linked in a reciprocal manner and can potentially produce a toxic cellular environment capable of attacking a variety of biomolecules as well as inhibiting energy production. Defining the roles that these two biochemical defects play in nigral neuronal loss will provide important insights into the aetiology of PD.

Bibliography

Schapira, A. H. V. (1995). Oxidative stress in Parkinsonâs disease. Neuropathology and Applied Neurobiology, 21(1), 3â9. Portico.

Authors 1

A. H. V. Schapira (first)

References 72 Referenced 80

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Dates

Type	When
Created	17 years, 3 months ago (May 12, 2008, 5:48 a.m.)
Deposited	1 year, 10 months ago (Oct. 26, 2023, 9:44 p.m.)
Indexed	1 week, 5 days ago (Aug. 24, 2025, 6:48 p.m.)
Issued	30 years, 7 months ago (Feb. 1, 1995)
Published	30 years, 7 months ago (Feb. 1, 1995)
Published Online	17 years, 3 months ago (May 12, 2008)
Published Print	30 years, 7 months ago (Feb. 1, 1995)

Funders 0

None

BibTeX

@article{Schapira_1995, title={Oxidative stress in Parkinson’s disease}, volume={21}, ISSN={1365-2990}, url={http://dx.doi.org/10.1111/j.1365-2990.1995.tb01022.x}, DOI={10.1111/j.1365-2990.1995.tb01022.x}, number={1}, journal={Neuropathology and Applied Neurobiology}, publisher={Wiley}, author={Schapira, A. H. V.}, year={1995}, month=feb, pages={3–9} }

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