DOI: 10.1111/j.1365-2990.1982.tb00275.x. COMPLETE CEREBRAL ISCHAEMIA IN THE RAT: AN ULTRASTRUCTURAL AND STEREOLOGICAL ANALYSIS OF THE DISTAL STRATUM RADIATUM IN THE HIPPOCAMPAL CA‐1 REGION

COMPLETE CEREBRAL ISCHAEMIA IN THE RAT: AN ULTRASTRUCTURAL AND STEREOLOGICAL ANALYSIS OF THE DISTAL STRATUM RADIATUM IN THE HIPPOCAMPAL CA‐1 REGION

10.1111/j.1365-2990.1982.tb00275.x

Crossref journal-article

Wiley

Neuropathology and Applied Neurobiology (311)

Abstract

Ekström von Lubitz D.K.J. & Diemer N.H. (1982) Neuropathology and Applied Neurobiology 8, 197–215Complete cerebral ischaemia in the rat: an ultrastructural and stereological analysis of the distal stratum radiatum in the hippocampal CA‐1 regionAn ultrastructural study and a stereological analysis of the distal stratum radiatum in the hippocampal CA‐1 region of the rat were performed after 10 min of complete cerebral ischaemia followed by 10, 20 and 60 min of blood reflow periods. Post‐ischaemic changes were mainly limited to the region of synaptic terminals which showed either clumping or dispersion of the synaptic vesicle pools and damage to synaptic membranes. Presynaptic terminals and astrocytes were swollen after 10 and 20 min of reflow, but this abated after 60 min. Mitochondria in neurons showed varying degrees of swelling, but in astrocytes their structure was normal. There were no changes in capillaries. After 20 and 60 min of blood reflow, disruption of cell membranes was observed, mainly in the vicinity of the synaptic terminals. The size of the extracellular space diminished by approximately 30% in all three ischaemic groups. The data show that synaptic terminals are a primary and early target in the development of postischaemic nerve cell damage.

Bibliography

LUBITZ, D. K. J. E. V., & DIEMER, N. H. (1982). COMPLETE CEREBRAL ISCHAEMIA IN THE RAT: AN ULTRASTRUCTURAL AND STEREOLOGICAL ANALYSIS OF THE DISTAL STRATUM RADIATUM IN THE HIPPOCAMPAL CAâ1 REGION. Neuropathology and Applied Neurobiology, 8(3), 197â215. Portico.

Authors 2

D. K. J. EKSTRÖM VON LUBITZ (first)
N. H. DIEMER (additional)

References 41 Referenced 31

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{'key': 'e_1_2_1_4_1', 'first-page': '43', 'volume-title': "Greenfield's Neuropathology", 'author': 'BRIERLEY J.B.', 'year': '1976'} / Greenfield's Neuropathology by BRIERLEY J.B. (1976)
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{'key': 'e_1_2_1_12_1', 'first-page': '271', 'article-title': 'The pathogenesis of irreversible cell injury in ischaemia', 'volume': '102', 'author': 'FARBER J.L.', 'year': '1981', 'journal-title': 'American Journal of Pathology'} / American Journal of Pathology / The pathogenesis of irreversible cell injury in ischaemia by FARBER J.L. (1981)
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VONLUBITZD.K.J.E.&DIEMERN.H.(1981)Stereological analysis of the ultrastructure of the distal stratum radiatum in the rat. InProceedings of the 3rd European Symposium for Stereology Ljubljana 1981 pp.511–517.
{'key': 'e_1_2_1_39_1', 'first-page': '1', 'article-title': 'Erkrankungen der Grosshirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik', 'volume': '28', 'author': 'VOGT C.', 'year': '1922', 'journal-title': 'Journal of Psychology and Neurology'} / Journal of Psychology and Neurology / Erkrankungen der Grosshirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik by VOGT C. (1922)
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Dates

Type	When
Created	17 years, 3 months ago (May 12, 2008, 6:12 a.m.)
Deposited	1 year, 9 months ago (Nov. 10, 2023, 2:37 p.m.)
Indexed	11 months, 4 weeks ago (Sept. 9, 2024, 1:56 a.m.)
Issued	43 years, 4 months ago (May 1, 1982)
Published	43 years, 4 months ago (May 1, 1982)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	43 years, 4 months ago (May 1, 1982)

Funders 0

None

BibTeX

@article{LUBITZ_1982, title={COMPLETE CEREBRAL ISCHAEMIA IN THE RAT: AN ULTRASTRUCTURAL AND STEREOLOGICAL ANALYSIS OF THE DISTAL STRATUM RADIATUM IN THE HIPPOCAMPAL CA‐1 REGION}, volume={8}, ISSN={1365-2990}, url={http://dx.doi.org/10.1111/j.1365-2990.1982.tb00275.x}, DOI={10.1111/j.1365-2990.1982.tb00275.x}, number={3}, journal={Neuropathology and Applied Neurobiology}, publisher={Wiley}, author={LUBITZ, D. K. J. EKSTRÖM VON and DIEMER, N. H.}, year={1982}, month=may, pages={197–215} }

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