DOI: 10.1111/j.1365-2990.1981.tb00093.x. CREUTZFELDT‐JACOB DISEASE: A GOLGI STUDY

CREUTZFELDT‐JACOB DISEASE: A GOLGI STUDY

10.1111/j.1365-2990.1981.tb00093.x

Crossref journal-article

Wiley

Neuropathology and Applied Neurobiology (311)

Abstract

A cerebral biopsy of a patient with Creutzfeldt‐Jacob (C‐J) disease was examined with the Golgi method. Distortion of soma and neuronal processes associated with vacuolization of the neuropil was observed. The main findings were decreased numbers of basal dendrites and of branches of the apical dendrite of the pyramidal cells, marked loss of synaptic spines, and varicosities in the proximal segment of some apical and basal dendrites. These changes, though non‐specific, may be interpreted as the result of deafferentation, although primary reactions related to C‐J disease cannot be ruled out. These changes underline the intense disruption of intracortical connections which takes place in this condition in addition to the neuronal loss.

Bibliography

FERRER, I., COSTA, F., & VECIANA, J. M. G. (1981). CREUTZFELDTâJACOB DISEASE: A GOLGI STUDY. Neuropathology and Applied Neurobiology, 7(3), 237â242. Portico.

Authors 3

I. FERRER (first)
F. COSTA (additional)
J. M. GRAU VECIANA (additional)

References 14 Referenced 18

{'key': 'e_1_2_1_2_1', 'first-page': '439', 'volume-title': 'Advances in Neurology', 'author': 'BERNSTEIN J.J.', 'year': '1975'} / Advances in Neurology by BERNSTEIN J.J. (1975)
10.1016/0014-4886(79)90224-3
10.1126/science.493989
{'key': 'e_1_2_1_5_1', 'first-page': '375', 'article-title': 'Changes in the dendritic organization of neurons in the cerebral cortex following deafferentation', 'volume': '96', 'author': 'JONES W.H.', 'year': '1962', 'journal-title': 'Journal of Anatomy'} / Journal of Anatomy / Changes in the dendritic organization of neurons in the cerebral cortex following deafferentation by JONES W.H. (1962)
{'key': 'e_1_2_1_6_1', 'first-page': '89', 'article-title': 'Some observations on transneuronal cell degeneration in the olfatory bulb of the rabbit', 'volume': '96', 'author': 'MATTHEWS M.R.', 'year': '1962', 'journal-title': 'Journal of Anatomy'} / Journal of Anatomy / Some observations on transneuronal cell degeneration in the olfatory bulb of the rabbit by MATTHEWS M.R. (1962)
{'key': 'e_1_2_1_7_1', 'first-page': '453', 'volume-title': 'Advances in Neurology', 'author': 'MEHRAEIN P.', 'year': '1975'} / Advances in Neurology by MEHRAEIN P. (1975)
10.1016/0014-4886(79)90075-X
{'key': 'e_1_2_1_9_1', 'first-page': '107', 'volume-title': 'Congenital and Acquired Cognitive Disorders', 'author': 'SCHEIBEL A.B.', 'year': '1979'} / Congenital and Acquired Cognitive Disorders by SCHEIBEL A.B. (1979)
10.1111/j.1528-1157.1974.tb03997.x
{'key': 'e_1_2_1_11_1', 'first-page': '11', 'volume-title': 'Aging, vol. 1, Clinical, Morphological, and Neurochemical Aspects in the Aging Central Nervous System', 'author': 'SCHEIBEL M.E.', 'year': '1975'} / Aging, vol. 1, Clinical, Morphological, and Neurochemical Aspects in the Aging Central Nervous System by SCHEIBEL M.E. (1975)
10.1002/aja.1001560407
{'key': 'e_1_2_1_13_1', 'first-page': '129', 'volume-title': 'Recent Advances in Neuropathology', 'author': 'TOMLINSON B.E.', 'year': '1979'} / Recent Advances in Neuropathology by TOMLINSON B.E. (1979)
10.3171/jns.1964.21.12.1033
10.1097/00005072-197801000-00002

Dates

Type	When
Created	17 years, 3 months ago (May 12, 2008, 6:14 a.m.)
Deposited	1 year, 9 months ago (Nov. 10, 2023, 1:36 p.m.)
Indexed	1 year, 3 months ago (May 22, 2024, 7:19 a.m.)
Issued	44 years, 4 months ago (May 1, 1981)
Published	44 years, 4 months ago (May 1, 1981)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	44 years, 4 months ago (May 1, 1981)

Funders 0

None

BibTeX

@article{FERRER_1981, title={CREUTZFELDT‐JACOB DISEASE: A GOLGI STUDY}, volume={7}, ISSN={1365-2990}, url={http://dx.doi.org/10.1111/j.1365-2990.1981.tb00093.x}, DOI={10.1111/j.1365-2990.1981.tb00093.x}, number={3}, journal={Neuropathology and Applied Neurobiology}, publisher={Wiley}, author={FERRER, I. and COSTA, F. and VECIANA, J. M. GRAU}, year={1981}, month=may, pages={237–242} }

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