DOI: 10.1111/j.1365-2958.2010.07088.x. <i>Caulobacter</i> PopZ forms a polar subdomain dictating sequential changes in pole composition and function

Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function

10.1111/j.1365-2958.2010.07088.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

SummaryThe bacterium Caulobacter crescentus has morphologically and functionally distinct cell poles that undergo sequential changes during the cell cycle. We show that the PopZ oligomeric network forms polar ribosome exclusion zones that change function during cell cycle progression. The parS/ParB chromosomal centromere is tethered to PopZ at one pole prior to the initiation of DNA replication. During polar maturation, the PopZ‐centromere tether is broken, and the PopZ zone at that pole then switches function to act as a recruitment factor for the ordered addition of multiple proteins that promote the transformation of the flagellated pole into a stalked pole. Stalked pole assembly, in turn, triggers the initiation of chromosome replication, which signals the formation of a new PopZ zone at the opposite cell pole, where it functions to anchor the newly duplicated centromere that has traversed the long axis of the cell. We propose that pole‐specific control of PopZ function co‐ordinates polar development and cell cycle progression by enabling independent assembly and tethering activities at the two cell poles.

Bibliography

Bowman, G. R., Comolli, L. R., Gaietta, G. M., Fero, M., Hong, S., Jones, Y., Lee, J. H., Downing, K. H., Ellisman, M. H., McAdams, H. H., & Shapiro, L. (2010). Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function. Molecular Microbiology, 76(1), 173â189. Portico.

Authors 11

Grant R. Bowman (first)
Luis R. Comolli (additional)
Guido M. Gaietta (additional)
Michael Fero (additional)
Sun‐Hae Hong (additional)
Ying Jones (additional)
Julie H. Lee (additional)
Kenneth H. Downing (additional)
Mark H. Ellisman (additional)
Harley H. McAdams (additional)
Lucy Shapiro (additional)

References 44 Referenced 119

Dates

Type	When
Created	15 years, 6 months ago (Feb. 10, 2010, 2:58 a.m.)
Deposited	1 year, 10 months ago (Oct. 14, 2023, 4:06 a.m.)
Indexed	1 month ago (July 24, 2025, 7:55 a.m.)
Issued	15 years, 4 months ago (March 29, 2010)
Published	15 years, 4 months ago (March 29, 2010)
Published Online	15 years, 4 months ago (March 29, 2010)
Published Print	15 years, 4 months ago (April 1, 2010)

Funders 0

None

BibTeX

@article{Bowman_2010, title={Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function}, volume={76}, ISSN={1365-2958}, url={http://dx.doi.org/10.1111/j.1365-2958.2010.07088.x}, DOI={10.1111/j.1365-2958.2010.07088.x}, number={1}, journal={Molecular Microbiology}, publisher={Wiley}, author={Bowman, Grant R. and Comolli, Luis R. and Gaietta, Guido M. and Fero, Michael and Hong, Sun‐Hae and Jones, Ying and Lee, Julie H. and Downing, Kenneth H. and Ellisman, Mark H. and McAdams, Harley H. and Shapiro, Lucy}, year={2010}, month=mar, pages={173–189} }

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