DOI: 10.1111/j.1365-2958.2004.04067.x. Structure, function and evolution of microbial adenylyl and guanylyl cyclases

Structure, function and evolution of microbial adenylyl and guanylyl cyclases

10.1111/j.1365-2958.2004.04067.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

SummaryCells respond to signals of both environmental and biological origin. Responses are often receptor mediated and result in the synthesis of so‐called second messengers that then provide a link between extracellular signals and downstream events, including changes in gene expression. Cyclic nucleotides (cAMP and cGMP) are among the most widely studied of this class of molecule. Research on their function and mode of action has been a paradigm for signal transduction systems and has shaped our understanding of this important area of biology. Cyclic nucleotides have diverse regulatory roles in both unicellular and multicellular organisms, highlighting the utility and success of this system of molecular communication. This review will examine the structural diversity of microbial adenylyl and guanylyl cyclases, the enzymes that synthesize cAMP and cGMP respectively. We will address the relationship of structure to biological function and speculate on the complex origin of these crucial regulatory molecules. A review is timely because the explosion of data from the various genome projects is providing new and exciting insights into protein function and evolution.

Bibliography

Baker, D. A., & Kelly, J. M. (2004). Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Molecular Microbiology, 52(5), 1229â1242. Portico.

Authors 2

David A. Baker (first)
John M. Kelly (additional)

References 71 Referenced 106

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Dates

Type	When
Created	21 years, 3 months ago (May 25, 2004, 5:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 7:58 a.m.)
Indexed	3 months, 4 weeks ago (May 6, 2025, 6:34 p.m.)
Issued	21 years, 4 months ago (April 28, 2004)
Published	21 years, 4 months ago (April 28, 2004)
Published Online	21 years, 4 months ago (April 28, 2004)
Published Print	21 years, 3 months ago (June 1, 2004)

Funders 0

None

BibTeX

@article{Baker_2004, title={Structure, function and evolution of microbial adenylyl and guanylyl cyclases}, volume={52}, ISSN={1365-2958}, url={http://dx.doi.org/10.1111/j.1365-2958.2004.04067.x}, DOI={10.1111/j.1365-2958.2004.04067.x}, number={5}, journal={Molecular Microbiology}, publisher={Wiley}, author={Baker, David A. and Kelly, John M.}, year={2004}, month=apr, pages={1229–1242} }

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    ]
  },
  "references-count": 71,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          2004,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1365-2958.2004.04067.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1365-2958.2004.04067.x",
  "relation": {},
  "ISSN": [
    "0950-382X",
    "1365-2958"
  ],
  "subject": [],
  "container-title-short": "Molecular Microbiology",
  "published": {
    "date-parts": [
      [
        2004,
        4,
        28
      ]
    ]
  }
}