DOI: 10.1111/j.1365-2958.1996.tb02521.x. Variability of gene order in different <i>Helicobacter pylori</i> strains contributes to genome diversity

Variability of gene order in different Helicobacter pylori strains contributes to genome diversity

10.1111/j.1365-2958.1996.tb02521.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

SummaryConsiderable genomic microdiversity has been reported previously among Helicobacter pylori isolates. We have constructed genome maps of four unrelated H. pylori strains (NCTC11637, NCTC11639, UA802 and UA861) using pulsed‐field gel electrophoresis (PFGE) with Notl and Nrul, hybridization with extracted PFGE DNA fragments and probing with 17 gene probes. These strains of H. pylori were compared with a fifth unrelated H. pylori strain NCTC11638 mapped previously. Considerable diversity in gene arrangement was evident among the five H, pylori maps, and no consistent gene clustering was found. The association of only four genes, katA (catalase gene), vacA (vacuo‐lating cytotoxin gene), hpaA (a putative adhesin gene), and pfr (bacterial ferritin gene) were generally conserved within approximately the same 25% of the genome; however, the order of these genes also varied. Our study demonstrates that macrodiversity, i.e. variability in gene order, in addition to microdiversity, is a characteristic of the H. pylori genome.

Bibliography

Jiang, Q., Hiratsuka, K., & Taylor, D. E. (1996). Variability of gene order in different Helicobacter pylori strains contributes to genome diversity. Molecular Microbiology, 20(4), 833â842. Portico.

Authors 3

Qin Jiang (first)
Koji Hiratsuka (additional)
Diane E. Taylor (additional)

References 55 Referenced 117

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 6, 2006, 6:44 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 3:39 p.m.)
Indexed	1 month ago (July 30, 2025, 11:32 a.m.)
Issued	29 years, 4 months ago (May 1, 1996)
Published	29 years, 4 months ago (May 1, 1996)
Published Online	18 years, 11 months ago (Oct. 6, 2006)
Published Print	29 years, 4 months ago (May 1, 1996)

Funders 0

None

BibTeX

@article{Jiang_1996, title={Variability of gene order in different Helicobacter pylori strains contributes to genome diversity}, volume={20}, ISSN={1365-2958}, url={http://dx.doi.org/10.1111/j.1365-2958.1996.tb02521.x}, DOI={10.1111/j.1365-2958.1996.tb02521.x}, number={4}, journal={Molecular Microbiology}, publisher={Wiley}, author={Jiang, Qin and Hiratsuka, Koji and Taylor, Diane E.}, year={1996}, month=may, pages={833–842} }

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