DOI: 10.1111/j.1365-2958.1995.tb02321.x. Exploring the <i>Mycoplasma capricolum</i> genome: a minimal cell reveals its physiology

Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology

10.1111/j.1365-2958.1995.tb02321.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

SummaryWe report on the analysis of 214 kb of the parasitic eubacterium Mycoplasma capricolum sequenced by genomic walking techniques. The 287 putative proteins detected to date represent about half of the estimated total number of 500 predicted for this organism. A large fraction of these (75%) can be assigned a likely function as a result of similarity searches. Several important features of the functional organization of this small genome are already apparent. Among these are (i) the expected relatively large number of enzymes involved in metabolic transport and activation, for efficient use of host cell nutrients; (ii) the presence of anabolic enzymes; (iii) the unexpected diversity of enzymes involved in DNA replication and repair: and (iv) a sizeable number of orthologues (82 so far) in Escherichia coli. This survey is beginning to provide a detailed view of how M. capricolum manages to maintain essential cellular processes with a genome much smaller than that of its bacterial relatives.

Bibliography

Bork, P., Ouzounis, C., Casari, G., Schneider, R., Sander, C., Dolan, M., Gilbert, W., & Gillevet, P. M. (1995). Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology. Molecular Microbiology, 16(5), 955â967. Portico.

Authors 8

Peer Bork (first)
Christos Ouzounis (additional)
Georg Casari (additional)
Reinhard Schneider (additional)
Chris Sander (additional)
Maureen Dolan (additional)
Walter Gilbert (additional)
Pat M. Gillevet (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 11:25 p.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 11:42 a.m.)
Indexed	4 weeks, 2 days ago (Aug. 7, 2025, 4:55 a.m.)
Issued	30 years, 3 months ago (June 1, 1995)
Published	30 years, 3 months ago (June 1, 1995)
Published Online	18 years, 10 months ago (Oct. 27, 2006)
Published Print	30 years, 3 months ago (June 1, 1995)

Funders 0

None

BibTeX

@article{Bork_1995, title={Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology}, volume={16}, ISSN={1365-2958}, url={http://dx.doi.org/10.1111/j.1365-2958.1995.tb02321.x}, DOI={10.1111/j.1365-2958.1995.tb02321.x}, number={5}, journal={Molecular Microbiology}, publisher={Wiley}, author={Bork, Peer and Ouzounis, Christos and Casari, Georg and Schneider, Reinhard and Sander, Chris and Dolan, Maureen and Gilbert, Walter and Gillevet, Pat M.}, year={1995}, month=jun, pages={955–967} }

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        6
      ]
    ]
  }
}