DOI: 10.1111/j.1365-2958.1992.tb01761.x. Recombination between genes encoding major outer surface proteins A and B of <i>Borrelia burgdorferi</i>

Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi

10.1111/j.1365-2958.1992.tb01761.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

Summary Borrelia burgdorferi causes Lyme disease, a multisystem illness that can persist in humans for many years. We describe recombination between homologous genes encoding the major outer surface proteins (Osps) A and B of B. burgdorferi which both deletes osp gene sequences and creates chimaeric gene fusions. Recombinant osp genes occur in multiple strains and encode unique proteins that lack some characteristic Osp epitopes. Antigenic variation in Osp through recombination may be relevant to the persistence of B. burgdorferi in an infected host, and has important implications for the utility of OspA and OspB as diagnostic or vaccine candidates for Lyme disease. We also describe Osp variation arising from nonsense mutations and sequence divergence, which may also represent significant sources of Osp polymorphism.

Bibliography

Rosa, P. A., Schwan, T., & Hogan, D. (1992). Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi. Molecular Microbiology, 6(20), 3031â3040. Portico.

Authors 3

Patricia A. Rosa (first)
Tom Schwan (additional)
Daniel Hogan (additional)

References 45 Referenced 111

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 27, 2006, 7:41 p.m.)
Deposited	1 year, 10 months ago (Oct. 23, 2023, 11:07 a.m.)
Indexed	3 months ago (June 4, 2025, 6:29 a.m.)
Issued	32 years, 11 months ago (Oct. 1, 1992)
Published	32 years, 11 months ago (Oct. 1, 1992)
Published Online	18 years, 10 months ago (Oct. 27, 2006)
Published Print	32 years, 11 months ago (Oct. 1, 1992)

Funders 0

None

BibTeX

@article{Rosa_1992, title={Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi}, volume={6}, ISSN={1365-2958}, url={http://dx.doi.org/10.1111/j.1365-2958.1992.tb01761.x}, DOI={10.1111/j.1365-2958.1992.tb01761.x}, number={20}, journal={Molecular Microbiology}, publisher={Wiley}, author={Rosa, Patricia A. and Schwan, Tom and Hogan, Daniel}, year={1992}, month=oct, pages={3031–3040} }

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