DOI: 10.1111/j.1365-2958.1992.tb01470.x. D‐E‐A‐D protein family of putative RNA helicases

D‐E‐A‐D protein family of putative RNA helicases

10.1111/j.1365-2958.1992.tb01470.x

Crossref journal-article

Wiley

Molecular Microbiology (311)

Abstract

SummaryRNA metabolism plays a central role in cell growth. It is essential to regulate RNA synthesis, processing, stability and degradation. Conformational changes in RNA are key elements in regulating cellular processes. Recently, an increasing number of putative RNA helicases from different organisms ranging from Escherichia coli to humans and viruses have been identified. They are Involved in diverse cellular functions such as RNA splicing, ribosome assembly, initiation of translation, spermatogenesis, embryogenesis, and cell growth and division. Based on sequence homologies these proteins were grouped in a family, the D‐E‐A‐D box protein family (D‐E‐A‐D = Asp‐Glu‐Ala‐Asp). Some of the better characterized members have been shown to possess ATP‐binding and hydrolysing activities as well as ATP‐dependent RNA helicase activities. Most of the genes encoding such proteins have been isolated from yeast, on which we will focus in this review. From sequence data, three of the members form a subfamily, the D‐E‐A‐H subfamily.

Bibliography

Schmid, S. R., & Linder, P. (1992). DâEâAâD protein family of putative RNA helicases. Molecular Microbiology, 6(3), 283â291. Portico.

Authors 2

S. R. Schmid (first)
P. Linder (additional)

References 54 Referenced 384

10.1016/S0021-9258(18)61430-9 / J Biol Chem by Abramsom R.D. (1987)
10.1016/0092-8674(90)90086-T
10.1073/pnas.87.4.1571
10.1093/nar/18.21.6447
10.1038/349487a0
10.1101/gad.1.5.445
10.1073/pnas.87.11.4236
10.1073/pnas.88.6.2113
10.1093/nar/18.18.5489
10.1038/332736a0
10.1093/nar/17.12.4713
10.1021/bi00380a009
10.1016/S0021-9258(17)39779-X / J Biol Chem by Grifo J.A. (1984)
10.1038/349717a0
10.1016/0092-8674(88)90216-4
10.1038/339562a0
10.1093/nar/18.18.5413
10.1128/MCB.11.3.1326
10.1002/j.1460-2075.1989.tb03577.x
10.1111/j.1365-2958.1991.tb00753.x
10.1038/349715a0
{'key': 'e_1_2_1_23_1', 'first-page': '886', 'volume': '3', 'author': 'Kalman M.', 'year': '1991', 'journal-title': 'New Biol'} / New Biol by Kalman M. (1991)
10.1016/0092-8674(91)90440-A
10.1093/nar/18.22.6559
10.1007/BF00318212
10.1038/352290c0
10.1016/0092-8674(91)90439-6
10.1093/nar/18.23.7003
10.1038/288167a0
10.1038/335611a0
10.1101/gad.4.6.905
10.1016/0092-8674(89)90125-6
10.1038/337121a0
10.1002/bies.950121103
10.1093/nar/16.21.10359
10.1002/j.1460-2075.1990.tb07466.x
10.1002/j.1460-2075.1988.tb03049.x
10.1093/nar/13.19.6867
10.1038/340246a0
10.1016/S0021-9258(17)39658-8
10.1016/0968-0004(88)90028-X
10.1128/MCB.9.9.4061
10.1128/MCB.10.3.1134
{'key': 'e_1_2_1_45_1', 'first-page': '549', 'volume-title': 'Isolation of the Isd Mutations in Saccharomyces cerevisiae', 'author': 'Sachs A.B.', 'year': '1990'} / Isolation of the Isd Mutations in Saccharomyces cerevisiae by Sachs A.B. (1990)
10.1126/science.2408148
10.1016/0092-8674(89)90334-6
10.1128/MCB.11.7.3463
10.1038/349494a0
10.1038/337084a0
10.1101/gad.5.5.773
10.1002/j.1460-2075.1986.tb04447.x
10.1101/gad.5.4.629
10.1128/jb.173.11.3291-3302.1991
10.1002/j.1460-2075.1982.tb01276.x

Dates

Type	When
Created	18 years, 9 months ago (Oct. 27, 2006, 8:18 p.m.)
Deposited	1 year, 10 months ago (Oct. 10, 2023, 5:34 p.m.)
Indexed	2 weeks, 3 days ago (Aug. 6, 2025, 8:28 a.m.)
Issued	33 years, 6 months ago (Feb. 1, 1992)
Published	33 years, 6 months ago (Feb. 1, 1992)
Published Online	18 years, 9 months ago (Oct. 27, 2006)
Published Print	33 years, 6 months ago (Feb. 1, 1992)

Funders 0

None

BibTeX

@article{Schmid_1992, title={D‐E‐A‐D protein family of putative RNA helicases}, volume={6}, ISSN={1365-2958}, url={http://dx.doi.org/10.1111/j.1365-2958.1992.tb01470.x}, DOI={10.1111/j.1365-2958.1992.tb01470.x}, number={3}, journal={Molecular Microbiology}, publisher={Wiley}, author={Schmid, S. R. and Linder, P.}, year={1992}, month=feb, pages={283–291} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T12:28:22Z",
    "timestamp": 1754483302223
  },
  "reference-count": 54,
  "publisher": "Wiley",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            10,
            27
          ]
        ],
        "date-time": "2006-10-27T00:00:00Z",
        "timestamp": 1161907200000
      },
      "content-version": "vor",
      "delay-in-days": 5382,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1992,
        2
      ]
    ]
  },
  "abstract": "<jats:title>Summary</jats:title><jats:p>RNA metabolism plays a central role in cell growth. It is essential to regulate RNA synthesis, processing, stability and degradation. Conformational changes in RNA are key elements in regulating cellular processes. Recently, an increasing number of putative RNA helicases from different organisms ranging from <jats:italic>Escherichia coli</jats:italic> to humans and viruses have been identified. They are Involved in diverse cellular functions such as RNA splicing, ribosome assembly, initiation of translation, spermatogenesis, embryogenesis, and cell growth and division. Based on sequence homologies these proteins were grouped in a family, the D\u2010E\u2010A\u2010D box protein family (D\u2010E\u2010A\u2010D = Asp\u2010Glu\u2010Ala\u2010Asp). Some of the better characterized members have been shown to possess ATP\u2010binding and hydrolysing activities as well as ATP\u2010dependent RNA helicase activities. Most of the genes encoding such proteins have been isolated from yeast, on which we will focus in this review. From sequence data, three of the members form a subfamily, the D\u2010E\u2010A\u2010H subfamily.</jats:p>",
  "DOI": "10.1111/j.1365-2958.1992.tb01470.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        28
      ]
    ],
    "date-time": "2006-10-28T00:18:15Z",
    "timestamp": 1161994695000
  },
  "page": "283-291",
  "source": "Crossref",
  "is-referenced-by-count": 384,
  "title": "D\u2010E\u2010A\u2010D protein family of putative RNA helicases",
  "prefix": "10.1111",
  "volume": "6",
  "author": [
    {
      "given": "S. R.",
      "family": "Schmid",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "P.",
      "family": "Linder",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2006,
        10,
        27
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "3826",
      "DOI": "10.1016/S0021-9258(18)61430-9",
      "volume": "262",
      "author": "Abramsom R.D.",
      "year": "1987",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(90)90086-T"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.4.1571"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/18.21.6447"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/349487a0"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.1.5.445"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.11.4236"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.6.2113"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/18.18.5489"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/332736a0"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/17.12.4713"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00380a009"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "8648",
      "DOI": "10.1016/S0021-9258(17)39779-X",
      "volume": "259",
      "author": "Grifo J.A.",
      "year": "1984",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/349717a0"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(88)90216-4"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/339562a0"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/18.18.5413"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.3.1326"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1989.tb03577.x"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1991.tb00753.x"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/349715a0"
    },
    {
      "key": "e_1_2_1_23_1",
      "first-page": "886",
      "volume": "3",
      "author": "Kalman M.",
      "year": "1991",
      "journal-title": "New Biol"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90440-A"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/18.22.6559"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00318212"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/352290c0"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90439-6"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/18.23.7003"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/288167a0"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/335611a0"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.4.6.905"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90125-6"
    },
    {
      "key": "e_1_2_1_34_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/337121a0"
    },
    {
      "key": "e_1_2_1_35_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bies.950121103"
    },
    {
      "key": "e_1_2_1_36_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/16.21.10359"
    },
    {
      "key": "e_1_2_1_37_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1990.tb07466.x"
    },
    {
      "key": "e_1_2_1_38_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1988.tb03049.x"
    },
    {
      "key": "e_1_2_1_39_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/13.19.6867"
    },
    {
      "key": "e_1_2_1_40_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/340246a0"
    },
    {
      "key": "e_1_2_1_41_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(17)39658-8"
    },
    {
      "key": "e_1_2_1_42_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0968-0004(88)90028-X"
    },
    {
      "key": "e_1_2_1_43_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.9.9.4061"
    },
    {
      "key": "e_1_2_1_44_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.10.3.1134"
    },
    {
      "key": "e_1_2_1_45_1",
      "first-page": "549",
      "volume-title": "Isolation of the Isd Mutations in Saccharomyces cerevisiae",
      "author": "Sachs A.B.",
      "year": "1990"
    },
    {
      "key": "e_1_2_1_46_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2408148"
    },
    {
      "key": "e_1_2_1_47_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90334-6"
    },
    {
      "key": "e_1_2_1_48_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.7.3463"
    },
    {
      "key": "e_1_2_1_49_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/349494a0"
    },
    {
      "key": "e_1_2_1_50_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/337084a0"
    },
    {
      "key": "e_1_2_1_51_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.5.5.773"
    },
    {
      "key": "e_1_2_1_52_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1986.tb04447.x"
    },
    {
      "key": "e_1_2_1_53_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.5.4.629"
    },
    {
      "key": "e_1_2_1_54_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.173.11.3291-3302.1991"
    },
    {
      "key": "e_1_2_1_55_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1982.tb01276.x"
    }
  ],
  "container-title": "Molecular Microbiology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2958.1992.tb01470.x",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2958.1992.tb01470.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2958.1992.tb01470.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        10
      ]
    ],
    "date-time": "2023-10-10T21:34:59Z",
    "timestamp": 1696973699000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2958.1992.tb01470.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1992,
        2
      ]
    ]
  },
  "references-count": 54,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1992,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1365-2958.1992.tb01470.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1365-2958.1992.tb01470.x",
  "relation": {},
  "ISSN": [
    "0950-382X",
    "1365-2958"
  ],
  "subject": [],
  "container-title-short": "Molecular Microbiology",
  "published": {
    "date-parts": [
      [
        1992,
        2
      ]
    ]
  }
}