DOI: 10.1111/j.1365-2826.1995.tb00724.x. Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function

Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function

10.1111/j.1365-2826.1995.tb00724.x

Crossref journal-article

Wiley

Journal of Neuroendocrinology (311)

Abstract

AbstractImpaired cognitive function and enhanced activity of the hypothalamic‐pituitary‐adrenocortical system are among the cardinal symptoms of major depression in humans that resolve after successful antidepressant treatment. We used a transgenic mouse model expressing antisense RNA complementary to that of glucocorticoid receptor (GR) mRNA to test the hypothesis that reduced GR function can cause these clinical disturbances. The transgenic mice show profound behavioural changes in a number of animal tests that are indicative of cognitive impairment. These mice also have elevated plasma corticotropin concentrations in response to stress. After long‐term treatment with moclobemide, a reversible inhibitor of monoamine oxidase type A that acts clinically as an antidepressant, both the behavioural deficits and the hormonal alterations disappeared. These observations suggest that a transgenic mouse with GR dysfunction may be a useful model for investigation of drug effects on the cognitive and neuroendocrine aspects of depression.

Bibliography

Montkowski, A., Barden, N., Wotjak, C., Stec, I., Ganster, J., Meaney, M., Engelmann, M., Reul, J. M. H. M., Landgraf, R., & Holsboer, F. (1995). LongâTerm Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function. Journal of Neuroendocrinology, 7(11), 841â845. Portico.

Authors 10

Alexandra Montkowski (first)
Nicholas Barden (additional)
Carsten Wotjak (additional)
Ingemar Stec (additional)
Julia Ganster (additional)
Michael Meaney (additional)
Mario Engelmann (additional)
Johannes M. H. M. Reul (additional)
Rainer Landgraf (additional)
Florian Holsboer (additional)

References 45 Referenced 135

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{'key': 'e_1_2_1_8_2', 'first-page': 'R865', 'article-title': 'Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression', 'volume': '268', 'author': 'Gotthardt U', 'year': '1995', 'journal-title': 'Am J Physiol.'} / Am J Physiol. / Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression by Gotthardt U (1995)
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{'key': 'e_1_2_1_17_2', 'first-page': '95', 'article-title': 'Brain corticosteroid receptor balance and homeostatic control', 'volume': '12', 'author': 'Kloet ER.', 'year': '1991', 'journal-title': 'Front Neuroendocrinol.'} / Front Neuroendocrinol. / Brain corticosteroid receptor balance and homeostatic control by Kloet ER. (1991)
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Dates

Type	When
Created	18 years, 11 months ago (Sept. 29, 2006, 5:39 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 4:55 p.m.)
Indexed	1 month, 4 weeks ago (July 7, 2025, 2:28 a.m.)
Issued	29 years, 10 months ago (Nov. 1, 1995)
Published	29 years, 10 months ago (Nov. 1, 1995)
Published Online	18 years, 11 months ago (Sept. 29, 2006)
Published Print	29 years, 10 months ago (Nov. 1, 1995)

Funders 0

None

BibTeX

@article{Montkowski_1995, title={Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function}, volume={7}, ISSN={1365-2826}, url={http://dx.doi.org/10.1111/j.1365-2826.1995.tb00724.x}, DOI={10.1111/j.1365-2826.1995.tb00724.x}, number={11}, journal={Journal of Neuroendocrinology}, publisher={Wiley}, author={Montkowski, Alexandra and Barden, Nicholas and Wotjak, Carsten and Stec, Ingemar and Ganster, Julia and Meaney, Michael and Engelmann, Mario and Reul, Johannes M. H. M. and Landgraf, Rainer and Holsboer, Florian}, year={1995}, month=nov, pages={841–845} }

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