DOI: 10.1111/j.1365-2788.1994.tb00394.x. Dendritic and histochemical development and ageing in patients with Down's syndrome

Dendritic and histochemical development and ageing in patients with Down's syndrome

10.1111/j.1365-2788.1994.tb00394.x

Crossref journal-article

Wiley

Journal of Intellectual Disability Research (311)

Abstract

ABSTRACT. Mental retardation and dementia characteristic of Down's syndrome (DS) have a complex pathogenesis. Golgi and immunohistochemical studies were done on DS patients and controls from foetuses and elderly adults. Golgi studies on the cerebral cortex revealed that the postsynaptic spines on the basal dendrites increase from neonate to 15 years of age and gradually decrease after 20 years in controls, but poorly increase in children and rapidly decrease in adults with DS. This deficient synaptogenesis and dendritic atrophy may be related to mental retardation. On the other hand, immunohistochem‐istry on proteins, whose genes are located on chromosome 21, revealed that c‐temiinal protein of beta‐amyloid appears in neurons of DS, S‐100‐positive glia increases in the hippocampus of neonates and adults, and membrane protein OK‐2 is expressed earlier and is more widespread in the DS brains. The overexpression and early appearance of gene products in DS brains may be related to the pathogenesis of or predisposition to mental disorders or to dendritic hypogenesis.

Bibliography

TAKASHIMA, S., IIDA, K., MITO, T., & ARIMA, M. (1994). Dendritic and histochemical development and ageing in patients with Downâs syndrome. Journal of Intellectual Disability Research, 38(3), 265â273. Portico.

Authors 4

S. TAKASHIMA (first)
K. IIDA (additional)
T. MITO (additional)
M. ARIMA (additional)

References 20 Referenced 95

10.1126/science.2964086
10.1002/ana.410200413
{'key': 'e_1_2_1_4_1', 'first-page': '133', 'volume-title': 'The Morphogenesis of Dawn Syndrome', 'author': 'Becker L.E.', 'year': '1991'} / The Morphogenesis of Dawn Syndrome by Becker L.E. (1991)
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Dates

Type	When
Created	15 years, 1 month ago (July 23, 2010, 3:22 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 3:50 p.m.)
Indexed	1 month ago (Aug. 6, 2025, 9:55 a.m.)
Issued	31 years, 3 months ago (June 1, 1994)
Published	31 years, 3 months ago (June 1, 1994)
Published Online	17 years, 2 months ago (June 28, 2008)
Published Print	31 years, 3 months ago (June 1, 1994)

Funders 0

None

BibTeX

@article{TAKASHIMA_1994, title={Dendritic and histochemical development and ageing in patients with Down’s syndrome}, volume={38}, ISSN={1365-2788}, url={http://dx.doi.org/10.1111/j.1365-2788.1994.tb00394.x}, DOI={10.1111/j.1365-2788.1994.tb00394.x}, number={3}, journal={Journal of Intellectual Disability Research}, publisher={Wiley}, author={TAKASHIMA, S. and IIDA, K. and MITO, T. and ARIMA, M.}, year={1994}, month=jun, pages={265–273} }

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