DOI: 10.1111/j.1365-2567.2005.02277.x. A novel mechanism of nuclear factor‐κB regulation by adenoviral protein 14·7K

A novel mechanism of nuclear factor‐κB regulation by adenoviral protein 14·7K

10.1111/j.1365-2567.2005.02277.x

Crossref journal-article

Wiley

Immunology (311)

Abstract

SummaryViruses have evolved many different ways to evade immune attacks. The adenoviral E3 protein 14·7K effectively inhibits antiviral immunity and inflammation. However, the underlying mechanism for this effect is unclear. Here we show that 14·7K is a potent inhibitor of nuclear factor (NF)‐κB transcriptional activity following Toll‐like receptor (TLR) or tumour necrosis factor (TNF) receptor signalling. The inhibition of the NF‐κB activity occurs downstream of IκBα degradation and NF‐κB translocation into the nucleus. Analysis of NF‐κB DNA binding reveals that 14·7K specifically inhibits p50 homodimer DNA binding and that this inhibition is mediated through the interaction of 14·7K with p50. We propose that 14·7K inhibits NF‐κB activity through directly blocking p50 binding to DNA and that this is the basis for its anti‐inflammatory properties. Our data also indicate a role for p50 homodimer‐dependent transcription in inflammation.

Bibliography

Carmody, R. J., Maguschak, K., & Chen, Y. H. (2005). A novel mechanism of nuclear factorâÎºB regulation by adenoviral protein 14Â·7K. Immunology, 117(2), 188â195. Portico.

Authors 3

Ruaidhrí J. Carmody (first)
Kimberly Maguschak (additional)
Youhai H. Chen (additional)

References 35 Referenced 15

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Dates

Type	When
Created	19 years, 9 months ago (Nov. 29, 2005, 5:45 a.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 1:49 p.m.)
Indexed	1 year, 2 months ago (June 19, 2024, 7:56 a.m.)
Issued	19 years, 9 months ago (Nov. 29, 2005)
Published	19 years, 9 months ago (Nov. 29, 2005)
Published Online	19 years, 9 months ago (Nov. 29, 2005)
Published Print	19 years, 7 months ago (Feb. 1, 2006)

Funders 0

None

BibTeX

@article{Carmody_2005, title={A novel mechanism of nuclear factor‐κB regulation by adenoviral protein 14·7K}, volume={117}, ISSN={1365-2567}, url={http://dx.doi.org/10.1111/j.1365-2567.2005.02277.x}, DOI={10.1111/j.1365-2567.2005.02277.x}, number={2}, journal={Immunology}, publisher={Wiley}, author={Carmody, Ruaidhrí J. and Maguschak, Kimberly and Chen, Youhai H.}, year={2005}, month=nov, pages={188–195} }

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