DOI: 10.1111/j.1365-2567.2004.01976.x. Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

10.1111/j.1365-2567.2004.01976.x

Crossref journal-article

Wiley

Immunology (311)

Abstract

SummaryAn understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4 (TLR4) – but also in a better appreciation of the complexity of the signalling pathways activated by LPS. Soon after the discovery of TLR4, the formation of a receptor complex in response to LPS, consisting of dimerized TLR4 and MD‐2, was described. Intracellular events following the formation of this receptor complex depend on different sets of adapters. An early response, which is dependent on MyD88 and MyD88‐like adapter (Mal), leads to the activation of nuclear factor‐κB (NF‐κB). A later response to LPS makes use of TIR‐domain‐containing adapter‐inducing interferon‐β (TRIF) and TRIF‐related adapter molecule (TRAM), and leads to the late activation of NF‐κB and IRF3, and to the induction of cytokines, chemokines, and other transcription factors. As LPS signal transduction is an area of intense research and rapid progress, this review is intended to sum up our present understanding of the events following LPS binding to TLR4, and we also attempt to create a model of the signalling pathways activated by LPS.

Bibliography

PÃ¥lssonâMcDermott, E. M., & OâNeill, L. A. J. (2004). Signal transduction by the lipopolysaccharide receptor, Tollâlike receptorâ4. Immunology, 113(2), 153â162. Portico.

Authors 2

Eva M. Pålsson‐McDermott (first)
Luke A. J. O'Neill (additional)

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Dates

Type	When
Created	20 years, 11 months ago (Sept. 17, 2004, 11:20 a.m.)
Deposited	1 year, 10 months ago (Oct. 13, 2023, 5:29 p.m.)
Indexed	6 hours, 13 minutes ago (Sept. 6, 2025, 4:02 p.m.)
Issued	20 years, 11 months ago (Sept. 17, 2004)
Published	20 years, 11 months ago (Sept. 17, 2004)
Published Online	20 years, 11 months ago (Sept. 17, 2004)
Published Print	20 years, 11 months ago (Oct. 1, 2004)

Funders 0

None

BibTeX

@article{P_lsson_McDermott_2004, title={Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4}, volume={113}, ISSN={1365-2567}, url={http://dx.doi.org/10.1111/j.1365-2567.2004.01976.x}, DOI={10.1111/j.1365-2567.2004.01976.x}, number={2}, journal={Immunology}, publisher={Wiley}, author={Pålsson‐McDermott, Eva M. and O’Neill, Luke A. J.}, year={2004}, month=sep, pages={153–162} }

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