DOI: 10.1111/j.1365-2559.1994.tb00568.x. The expression of the B‐cell marker mb‐1 (CD79a) in Hodgkin's disease

The expression of the B‐cell marker mb‐1 (CD79a) in Hodgkin's disease

10.1111/j.1365-2559.1994.tb00568.x

Crossref journal-article

Wiley

Histopathology (311)

Abstract

Recent evidence indicates that membrane‐bound immunoglobulin on B lymphocytes is associated with a molecule which comprises the products of the mb‐1 and B29 genes. This molecule is a highly specific marker for B‐cells, presumably because of its central functional role in antigen triggering, and has recently been clustered as CD79a at the 5th Leucocyte Workshop. Recently there has been controversy surrounding reports of B‐cell antigen expression by Reed–Sternberg and related cells, and we have therefore studied 108 cases of Hodgkin's disease immunohistochemically using a novel antibody which detects mb‐1 protein in paraffin sections. The results were compared with those achieved using antibody L26 to detect CD20. The mb‐1 protein was present in the neoplastic cells in all 14 cases of lymphocyte predominance Hodgkin's disease studied, and CD20 immunoreactivity was also found in seven of the eight cases of this subtype studied. Of the non‐lymphocyte predominance cases, 20% (19/94) expressed mb‐1 and 30% (20/67) CD20 in the Reed–Sternberg cells, but the cells positive for either of these two markers usually constituted only a very small proportion of the neoplastic population. However, in occasional cases (one of 94 for mb‐1 and five of 67 for CD20), more than 50% of the neoplastic cells expressed one or both B‐cell antigens. These results confirm the B‐cell origin of the neoplastic cells in lymphocyte predominance Hodgkin's disease, but they also indicate that, contrary to our previous study, mb‐1 expression may occasionally be found in what appears, on histological grounds, to be other types of Hodgkin's disease.

Bibliography

KORKOLOPOULOU, P., CORDELL, J., JONES, M., KAKLAMANIS, L., TSENGA, A., GATTER, K. C., & MASON, D. Y. (1994). The expression of the Bâcell marker mbâ1 (CD79a) in Hodgkinâs disease. Histopathology, 24(6), 511â515. Portico.

Authors 7

P. KORKOLOPOULOU (first)
J. CORDELL (additional)
M. JONES (additional)
L. KAKLAMANIS (additional)
A. TSENGA (additional)
K.C. GATTER (additional)
D.Y. MASON (additional)

References 36 Referenced 48

10.1136/jcp.35.2.159
{'key': 'e_1_2_1_3_2', 'first-page': '370', 'article-title': 'Lectin receptors as markers of lymphoid cells. II: Reed–Sternberg cells share lectin‐binding properties of monocyte macrophages.', 'volume': '116', 'author': 'Strauchen JA', 'year': '1984', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Lectin receptors as markers of lymphoid cells. II: Reed–Sternberg cells share lectin‐binding properties of monocyte macrophages. by Strauchen JA (1984)
{'key': 'e_1_2_1_4_2', 'first-page': '601', 'article-title': 'Possible origin of Reed–Sternberg cell from an interdigitating reticulum cell.', 'volume': '66', 'author': 'Kadin ME', 'year': '1982', 'journal-title': 'Cancer Treat. Rep.'} / Cancer Treat. Rep. / Possible origin of Reed–Sternberg cell from an interdigitating reticulum cell. by Kadin ME (1982)
{'key': 'e_1_2_1_5_2', 'first-page': '353', 'article-title': 'Cultured Reed–Sternberg cells HDLM‐1 and KM‐H2 can be induced to become histiocyte‐like cells.', 'volume': '137', 'author': 'Hsu SM', 'year': '1990', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Cultured Reed–Sternberg cells HDLM‐1 and KM‐H2 can be induced to become histiocyte‐like cells. by Hsu SM (1990)
10.1182/blood.V66.4.848.848 / Blood / The expression of Hodgkin's disease associated antigen Ki‐1 in reactive and neoplastic lymphoid tissue: evidence that Reed–Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. by Stein H (1985)
10.1038/bjc.1984.74
10.1016/S0046-8177(86)80084-3
10.1182/blood.V70.1.186.186 / Blood / Clonal immunoglobulin gene rearrangement in tissues involved by Hodgkin's disease. by Brinker MGL (1987)
10.1136/jcp.40.12.1405
10.1002/path.1711510305
10.1111/j.1365-2559.1988.tb02021.x
{'key': 'e_1_2_1_13_2', 'first-page': '701', 'article-title': "Expression of B‐cell antigens by Hodgkin's and Reed–Sternberg cells.", 'volume': '139', 'author': 'Schmid C', 'year': '1991', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Expression of B‐cell antigens by Hodgkin's and Reed–Sternberg cells. by Schmid C (1991)
{'key': 'e_1_2_1_14_2', 'first-page': '475', 'article-title': "Coexpression of CD15 and CD20 by Reed–Sternberg cells in Hodgkin's disease.", 'volume': '139', 'author': 'Zukerberg LR', 'year': '1991', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Coexpression of CD15 and CD20 by Reed–Sternberg cells in Hodgkin's disease. by Zukerberg LR (1991)
10.1111/j.1365-2559.1987.tb01869.x
10.1002/ijc.2910400205
{'key': 'e_1_2_1_17_2', 'first-page': '345', 'article-title': "Expression of T‐cell antigens on Reed–Sternberg cells in a subset of patients with nodular sclerosing and mixed cellularity Hodgkin's disease.", 'volume': '130', 'author': 'Kadin ME', 'year': '1988', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Expression of T‐cell antigens on Reed–Sternberg cells in a subset of patients with nodular sclerosing and mixed cellularity Hodgkin's disease. by Kadin ME (1988)
10.1182/blood.V74.8.2624.2624 / Blood / Immunophenotypes of Reed–Sternberg cells: a study of 19 cases of Hodgkin's disease in plastic embedded sections. by Casey TT (1989)
10.1111/j.1365-2559.1989.tb01625.x
10.1016/S0140-6736(89)92997-8
10.1093/ajcp/86.3.292
{'key': 'e_1_2_1_22_2', 'first-page': '211', 'article-title': "Hodgkin's disease, lymphocyte predominance type, nodular—further evidence for a B cell derivation: L & H variants of Reed–Sternberg cells express L26, a pan B cell marker.", 'volume': '133', 'author': 'Pinkus GS', 'year': '1988', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Hodgkin's disease, lymphocyte predominance type, nodular—further evidence for a B cell derivation: L & H variants of Reed–Sternberg cells express L26, a pan B cell marker. by Pinkus GS (1988)
10.1111/j.1365-2559.1990.tb01084.x
10.1111/j.1365-2559.1993.tb00092.x
10.1097/00000478-199405000-00014
{'key': 'e_1_2_1_26_2', 'first-page': '1063', 'article-title': "The pathology and nomenclature of Hodgkin's disease.", 'volume': '26', 'author': 'Lukes RJ', 'year': '1966', 'journal-title': 'Cancer Res.'} / Cancer Res. / The pathology and nomenclature of Hodgkin's disease. by Lukes RJ (1966)
{'key': 'e_1_2_1_27_2', 'volume-title': 'Leucocyte Typing V: White Cell Differentiation Antigens.', 'author': 'Schlossman S', 'year': '1994'} / Leucocyte Typing V: White Cell Differentiation Antigens. by Schlossman S (1994)
{'key': 'e_1_2_1_28_2', 'first-page': '1215', 'article-title': 'Antibody L26 recognises an intracellular epitope on the B‐cell associated CD20 antigen.', 'volume': '136', 'author': 'Mason DY', 'year': '1990', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Antibody L26 recognises an intracellular epitope on the B‐cell associated CD20 antigen. by Mason DY (1990)
10.1177/32.2.6198355
10.4049/jimmunol.147.8.2474 / J. Immunol. / The IgM associated protein mb‐1 as a marker of normal and neoplastic B cells. by Mason DY (1991)
10.1002/eji.1830221044
10.1038/343760a0
10.1016/0167-5699(91)90054-W
10.1016/0167-5699(91)90053-V
10.1002/eji.1830201238
10.4049/jimmunol.146.11.3881 / J. Immunol. / The membrane IgM‐associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb‐1 gene. by Noesel CJM (1991)
{'key': 'e_1_2_1_37_2', 'first-page': '96', 'article-title': "Rearranged antigen receptor genes in Hodgkin's disease.", 'volume': '70', 'author': 'Sundeen J', 'year': '1987', 'journal-title': 'Blood'} / Blood / Rearranged antigen receptor genes in Hodgkin's disease. by Sundeen J (1987)

Dates

Type	When
Created	15 years, 1 month ago (Aug. 4, 2010, 9:09 p.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 1:31 p.m.)
Indexed	2 months, 1 week ago (June 27, 2025, 3:29 a.m.)
Issued	31 years, 3 months ago (June 1, 1994)
Published	31 years, 3 months ago (June 1, 1994)
Published Online	18 years, 5 months ago (April 3, 2007)
Published Print	31 years, 3 months ago (June 1, 1994)

Funders 0

None

BibTeX

@article{KORKOLOPOULOU_1994, title={The expression of the B‐cell marker mb‐1 (CD79a) in Hodgkin’s disease}, volume={24}, ISSN={1365-2559}, url={http://dx.doi.org/10.1111/j.1365-2559.1994.tb00568.x}, DOI={10.1111/j.1365-2559.1994.tb00568.x}, number={6}, journal={Histopathology}, publisher={Wiley}, author={KORKOLOPOULOU, P. and CORDELL, J. and JONES, M. and KAKLAMANIS, L. and TSENGA, A. and GATTER, K.C. and MASON, D.Y.}, year={1994}, month=jun, pages={511–515} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        27
      ]
    ],
    "date-time": "2025-06-27T07:29:16Z",
    "timestamp": 1751009356977
  },
  "reference-count": 36,
  "publisher": "Wiley",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            4,
            3
          ]
        ],
        "date-time": "2007-04-03T00:00:00Z",
        "timestamp": 1175558400000
      },
      "content-version": "vor",
      "delay-in-days": 4689,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [
      "onlinelibrary.wiley.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        6
      ]
    ]
  },
  "abstract": "<jats:p>Recent evidence indicates that membrane\u2010bound immunoglobulin on B lymphocytes is associated with a molecule which comprises the products of the <jats:italic>mb\u20101</jats:italic> and <jats:italic>B29</jats:italic> genes. This molecule is a highly specific marker for B\u2010cells, presumably because of its central functional role in antigen triggering, and has recently been clustered as CD79a at the 5th Leucocyte Workshop. Recently there has been controversy surrounding reports of B\u2010cell antigen expression by Reed\u2013Sternberg and related cells, and we have therefore studied 108 cases of Hodgkin's disease immunohistochemically using a novel antibody which detects mb\u20101 protein in paraffin sections. The results were compared with those achieved using antibody L26 to detect CD20. The mb\u20101 protein was present in the neoplastic cells in all 14 cases of lymphocyte predominance Hodgkin's disease studied, and CD20 immunoreactivity was also found in seven of the eight cases of this subtype studied. Of the non\u2010lymphocyte predominance cases, 20% (19/94) expressed mb\u20101 and 30% (20/67) CD20 in the Reed\u2013Sternberg cells, but the cells positive for either of these two markers usually constituted only a very small proportion of the neoplastic population. However, in occasional cases (one of 94 for mb\u20101 and five of 67 for CD20), more than 50% of the neoplastic cells expressed one or both B\u2010cell antigens. These results confirm the B\u2010cell origin of the neoplastic cells in lymphocyte predominance Hodgkin's disease, but they also indicate that, contrary to our previous study, mb\u20101 expression may occasionally be found in what appears, on histological grounds, to be other types of Hodgkin's disease.</jats:p>",
  "DOI": "10.1111/j.1365-2559.1994.tb00568.x",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        8,
        5
      ]
    ],
    "date-time": "2010-08-05T01:09:49Z",
    "timestamp": 1280970589000
  },
  "page": "511-515",
  "update-policy": "http://dx.doi.org/10.1002/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 48,
  "title": "The expression of the B\u2010cell marker mb\u20101 (CD79a) in Hodgkin's disease",
  "prefix": "10.1111",
  "volume": "24",
  "author": [
    {
      "given": "P.",
      "family": "KORKOLOPOULOU",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "J.",
      "family": "CORDELL",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M.",
      "family": "JONES",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "L.",
      "family": "KAKLAMANIS",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "TSENGA",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "K.C.",
      "family": "GATTER",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "D.Y.",
      "family": "MASON",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2007,
        4,
        3
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jcp.35.2.159"
    },
    {
      "key": "e_1_2_1_3_2",
      "first-page": "370",
      "article-title": "Lectin receptors as markers of lymphoid cells. II: Reed\u2013Sternberg cells share lectin\u2010binding properties of monocyte macrophages.",
      "volume": "116",
      "author": "Strauchen JA",
      "year": "1984",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_4_2",
      "first-page": "601",
      "article-title": "Possible origin of Reed\u2013Sternberg cell from an interdigitating reticulum cell.",
      "volume": "66",
      "author": "Kadin ME",
      "year": "1982",
      "journal-title": "Cancer Treat. Rep."
    },
    {
      "key": "e_1_2_1_5_2",
      "first-page": "353",
      "article-title": "Cultured Reed\u2013Sternberg cells HDLM\u20101 and KM\u2010H2 can be induced to become histiocyte\u2010like cells.",
      "volume": "137",
      "author": "Hsu SM",
      "year": "1990",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "crossref",
      "first-page": "848",
      "DOI": "10.1182/blood.V66.4.848.848",
      "article-title": "The expression of Hodgkin's disease associated antigen Ki\u20101 in reactive and neoplastic lymphoid tissue: evidence that Reed\u2013Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.",
      "volume": "66",
      "author": "Stein H",
      "year": "1985",
      "journal-title": "Blood"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/bjc.1984.74"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0046-8177(86)80084-3"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "crossref",
      "first-page": "186",
      "DOI": "10.1182/blood.V70.1.186.186",
      "article-title": "Clonal immunoglobulin gene rearrangement in tissues involved by Hodgkin's disease.",
      "volume": "70",
      "author": "Brinker MGL",
      "year": "1987",
      "journal-title": "Blood"
    },
    {
      "key": "e_1_2_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1136/jcp.40.12.1405"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/path.1711510305"
    },
    {
      "key": "e_1_2_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2559.1988.tb02021.x"
    },
    {
      "key": "e_1_2_1_13_2",
      "first-page": "701",
      "article-title": "Expression of B\u2010cell antigens by Hodgkin's and Reed\u2013Sternberg cells.",
      "volume": "139",
      "author": "Schmid C",
      "year": "1991",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_14_2",
      "first-page": "475",
      "article-title": "Coexpression of CD15 and CD20 by Reed\u2013Sternberg cells in Hodgkin's disease.",
      "volume": "139",
      "author": "Zukerberg LR",
      "year": "1991",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2559.1987.tb01869.x"
    },
    {
      "key": "e_1_2_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/ijc.2910400205"
    },
    {
      "key": "e_1_2_1_17_2",
      "first-page": "345",
      "article-title": "Expression of T\u2010cell antigens on Reed\u2013Sternberg cells in a subset of patients with nodular sclerosing and mixed cellularity Hodgkin's disease.",
      "volume": "130",
      "author": "Kadin ME",
      "year": "1988",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_18_2",
      "doi-asserted-by": "crossref",
      "first-page": "2624",
      "DOI": "10.1182/blood.V74.8.2624.2624",
      "article-title": "Immunophenotypes of Reed\u2013Sternberg cells: a study of 19 cases of Hodgkin's disease in plastic embedded sections.",
      "volume": "74",
      "author": "Casey TT",
      "year": "1989",
      "journal-title": "Blood"
    },
    {
      "key": "e_1_2_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2559.1989.tb01625.x"
    },
    {
      "key": "e_1_2_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0140-6736(89)92997-8"
    },
    {
      "key": "e_1_2_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/ajcp/86.3.292"
    },
    {
      "key": "e_1_2_1_22_2",
      "first-page": "211",
      "article-title": "Hodgkin's disease, lymphocyte predominance type, nodular\u2014further evidence for a B cell derivation: L & H variants of Reed\u2013Sternberg cells express L26, a pan B cell marker.",
      "volume": "133",
      "author": "Pinkus GS",
      "year": "1988",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2559.1990.tb01084.x"
    },
    {
      "key": "e_1_2_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2559.1993.tb00092.x"
    },
    {
      "key": "e_1_2_1_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00000478-199405000-00014"
    },
    {
      "key": "e_1_2_1_26_2",
      "first-page": "1063",
      "article-title": "The pathology and nomenclature of Hodgkin's disease.",
      "volume": "26",
      "author": "Lukes RJ",
      "year": "1966",
      "journal-title": "Cancer Res."
    },
    {
      "key": "e_1_2_1_27_2",
      "volume-title": "Leucocyte Typing V: White Cell Differentiation Antigens.",
      "author": "Schlossman S",
      "year": "1994"
    },
    {
      "key": "e_1_2_1_28_2",
      "first-page": "1215",
      "article-title": "Antibody L26 recognises an intracellular epitope on the B\u2010cell associated CD20 antigen.",
      "volume": "136",
      "author": "Mason DY",
      "year": "1990",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "e_1_2_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1177/32.2.6198355"
    },
    {
      "key": "e_1_2_1_30_2",
      "doi-asserted-by": "crossref",
      "first-page": "2474",
      "DOI": "10.4049/jimmunol.147.8.2474",
      "article-title": "The IgM associated protein mb\u20101 as a marker of normal and neoplastic B cells.",
      "volume": "147",
      "author": "Mason DY",
      "year": "1991",
      "journal-title": "J. Immunol."
    },
    {
      "key": "e_1_2_1_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/eji.1830221044"
    },
    {
      "key": "e_1_2_1_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/343760a0"
    },
    {
      "key": "e_1_2_1_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0167-5699(91)90054-W"
    },
    {
      "key": "e_1_2_1_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0167-5699(91)90053-V"
    },
    {
      "key": "e_1_2_1_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/eji.1830201238"
    },
    {
      "key": "e_1_2_1_36_2",
      "doi-asserted-by": "crossref",
      "first-page": "3881",
      "DOI": "10.4049/jimmunol.146.11.3881",
      "article-title": "The membrane IgM\u2010associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb\u20101 gene.",
      "volume": "146",
      "author": "Noesel CJM",
      "year": "1991",
      "journal-title": "J. Immunol."
    },
    {
      "key": "e_1_2_1_37_2",
      "first-page": "96",
      "article-title": "Rearranged antigen receptor genes in Hodgkin's disease.",
      "volume": "70",
      "author": "Sundeen J",
      "year": "1987",
      "journal-title": "Blood"
    }
  ],
  "container-title": "Histopathology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2559.1994.tb00568.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2559.1994.tb00568.x",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        24
      ]
    ],
    "date-time": "2023-10-24T17:31:42Z",
    "timestamp": 1698168702000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2559.1994.tb00568.x"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        6
      ]
    ]
  },
  "references-count": 36,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1994,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1111/j.1365-2559.1994.tb00568.x"
  ],
  "URL": "http://dx.doi.org/10.1111/j.1365-2559.1994.tb00568.x",
  "relation": {},
  "ISSN": [
    "0309-0167",
    "1365-2559"
  ],
  "subject": [],
  "container-title-short": "Histopathology",
  "published": {
    "date-parts": [
      [
        1994,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "2007-04-03",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}