DOI: 10.1111/j.1365-2362.1988.tb01165.x. Effect of calcium intake on serum levels of 25‐hydroxyvitamin D3

Effect of calcium intake on serum levels of 25‐hydroxyvitamin D3

10.1111/j.1365-2362.1988.tb01165.x

Crossref journal-article

Wiley

European Journal of Clinical Investigation (311)

Abstract

Abstract. The effects of high calcium intake on vitamin D metabolism were investigated. To the normal diet of 14 healthy men, 2 g calcium were added daily for 6–7 weeks. The mean serum concentration of 25‐hydroxyvitamin D3 increased from 73 ± 7 to 94 ± 6 nmol l‐1 (P<0·05, Student's unpaired t‐test; P<0·01, paired t‐test) in the subjects receiving calcium, whereas there was only a minimal increase, from 67 ± 5 to 71 ± 4 nmol l‐1 in a control group on a normal diet. At the end of the study the difference between the test group and the controls was highly significant (P<0·005). The calcium loading caused a statistically significant depression of the serum levels of 1,25‐dihydroxyvitamin D. The results obtained are in agreement with previous studies in rats and indicate that calcium intake is of some importance for the serum level of 25‐hydroxyvitamin D3. The findings are discussed in relation to our previous finding that there is a relationship between high 25‐hydroxyvitamin D3 levels and hypercalciuria in renal‐stone formers.

Bibliography

BERLIN, T., & BJÃRKHEM, I. (1988). Effect of calcium intake on serum levels of 25âhydroxyvitamin D3. European Journal of Clinical Investigation, 18(1), 52â55. Portico.

Authors 2

T. BERLIN (first)
I. BJÖRKHEM (additional)

References 23 Referenced 36

10.3109/00365598209179765
10.3109/00365518609083684
10.3109/00365598209179746
JongenMJM.The role of vitamin D in the pathogenisis of urinary calcium‐stone disease.PhD Thesis Vrije University Juuriaans by Amsterdam 1983.
10.1001/archinte.145.4.681
10.1172/JCI108696
{'key': 'e_1_2_1_8_2', 'first-page': '955', 'article-title': 'Increased serum 1,25‐dihydroxyvitamin D3 in idiopathic hypercalciuria', 'volume': '90', 'author': 'Shen FH', 'year': '1977', 'journal-title': 'J Lab Clin Med'} / J Lab Clin Med / Increased serum 1,25‐dihydroxyvitamin D3 in idiopathic hypercalciuria by Shen FH (1977)
10.1210/jcem-51-5-998
10.1210/jcem-58-1-161
10.1056/NEJM198407123110201
10.1016/0002-9343(82)90567-8
{'key': 'e_1_2_1_13_2', 'first-page': '723', 'article-title': 'Studies on the relationship between vitamin D3 status and urinary excretion of calcium in healthy subjects: effects of increased levels of 25‐hydroxyvitamin D3', 'volume': '46', 'author': 'Berlin T', 'year': '1986', 'journal-title': 'Scand J Urol Nephrol'} / Scand J Urol Nephrol / Studies on the relationship between vitamin D3 status and urinary excretion of calcium in healthy subjects: effects of increased levels of 25‐hydroxyvitamin D3 by Berlin T (1986)
10.1016/S0006-291X(87)80071-2
10.1016/0009-8981(80)90079-0
{'key': 'e_1_2_1_16_2', 'first-page': '167', 'article-title': 'Mass fragmentography of 25‐hydroxyvitamin D3. Quantitative mass spectrometry', 'author': 'Björkhem I', 'year': '1978', 'journal-title': 'Life Sci'} / Life Sci / Mass fragmentography of 25‐hydroxyvitamin D3. Quantitative mass spectrometry by Björkhem I (1978)
10.1016/S0076-6879(80)67047-5
10.1210/jcem-58-1-91
10.1172/JCI111568
10.1172/JCI112745
10.1016/S0021-9258(17)38181-4 / J Biol Chem / Assay and properties of a mitochondrial 25‐hydroxylase active on vitamin D3 by Björkhem I (1978)
10.1042/bj1840491
{'key': 'e_1_2_1_23_2', 'volume-title': 'Vitamin D, Metabolism and Function. Monographs on Endocrinology', 'author': 'DeLuca HF.', 'year': '1979'} / Vitamin D, Metabolism and Function. Monographs on Endocrinology by DeLuca HF. (1979)
10.1159/000176984

Dates

Type	When
Created	17 years, 5 months ago (March 20, 2008, 9:03 a.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 3:33 a.m.)
Indexed	4 months, 2 weeks ago (April 19, 2025, 4:48 a.m.)
Issued	37 years, 7 months ago (Feb. 1, 1988)
Published	37 years, 7 months ago (Feb. 1, 1988)
Published Online	17 years, 5 months ago (March 20, 2008)
Published Print	37 years, 7 months ago (Feb. 1, 1988)

Funders 0

None

BibTeX

@article{BERLIN_1988, title={Effect of calcium intake on serum levels of 25‐hydroxyvitamin D3}, volume={18}, ISSN={1365-2362}, url={http://dx.doi.org/10.1111/j.1365-2362.1988.tb01165.x}, DOI={10.1111/j.1365-2362.1988.tb01165.x}, number={1}, journal={European Journal of Clinical Investigation}, publisher={Wiley}, author={BERLIN, T. and BJÖRKHEM, I.}, year={1988}, month=feb, pages={52–55} }

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