DOI: 10.1111/j.1365-2362.1983.tb00119.x. Calcium malabsorption in the elderly: the effect of treatment with oral 25‐hydroxyvitamin D<sub>3</sub>

Calcium malabsorption in the elderly: the effect of treatment with oral 25‐hydroxyvitamin D3

10.1111/j.1365-2362.1983.tb00119.x

Crossref journal-article

Wiley

European Journal of Clinical Investigation (311)

Abstract

Abstract. Calcium malabsorption is common in the elderly and may contribute to the development of age‐related bone loss. To investigate its cause, we have measured radio‐calcium absorption, plasma 25‐hydroxyvitamin D, 1,25‐dihydroxyvitamin D and parathyroid hormone in forty‐eight elderly women with a normal plasma creatinine. Calcium malabsorption was associated with low 25‐hydroxyvitamin D concentrations and was corrected by increasing these into the normal range by treatment with oral 25‐hydroxyvitamin D3. Treatment also increased 1,25‐dihydroxyvitamin D, and decreased parathyroid hormone concentrations.Before treatment, plasma parathyroid hormone was related to plasma creatinine but not to 25‐hydroxyvitamin D, and the change in absorption on treatment correlated inversely with plasma creatinine. 51Cr EDTA clearance was measured in sixteen elderly women and confirmed that renal impairment was common even with a plasma creatinine in the normal range. Our results suggest that calcium malabsorption in the elderly is predominantly due to vitamin D deficiency; renal impairment is also common and contributes to the malabsorption by increasing the requirements for vitamin D.

Bibliography

FRANCIS, R. M., PEACOCK, M., STORER, J. H., DAVIES, A. E. J., BROWN, W. B., & NORDIN, B. E. C. (1983). Calcium malabsorption in the elderly: the effect of treatment with oral 25âhydroxyvitamin D3. European Journal of Clinical Investigation, 13(5), 391â396. Portico.

Authors 6

R. M. FRANCIS (first)
M. PEACOCK (additional)
J. H. STORER (additional)
A. E. J. DAVIES (additional)
W. B. BROWN (additional)
B. E. C. NORDIN (additional)

References 29 Referenced 91

10.1016/S0140-6736(70)91344-9
{'key': 'e_1_2_1_3_2', 'first-page': '442', 'article-title': 'Calcium absorption in the elderly', 'volume': '215', 'author': 'Nordin BEC', 'year': '1976', 'journal-title': 'Calcif-Tissue Res'} / Calcif-Tissue Res / Calcium absorption in the elderly by Nordin BEC (1976)
10.1172/JCI107461
10.1016/S0300-595X(73)80045-3
{'key': 'e_1_2_1_6_2', 'first-page': '68', 'article-title': 'Intestinal absorption of calcium and phosphorus', 'volume': '40', 'author': 'Wasserman RH.', 'year': '1981', 'journal-title': 'Fed Proc'} / Fed Proc / Intestinal absorption of calcium and phosphorus by Wasserman RH. (1981)
10.1093/ageing/9.4.249
10.1126/science.6251551
10.1136/bmj.1.6158.221
10.1136/bmj.2.6185.303
10.1042/cs0550213
10.1515/9783112330029-177 / Vitamin D, Basic Research and its Clinical Application by Skinner RK. (1979)
10.1038/228764a0
10.1038/228763a0
10.1056/NEJM197711032971804
10.1172/JCI102286
10.1016/S0140-6736(67)92781-X
10.1016/0009-8981(76)90202-3
10.1016/0009-8981(80)90060-1
10.1016/0009-8981(80)90010-8
{'key': 'e_1_2_1_21_2', 'first-page': '556', 'volume-title': 'Calcium, Phosphate and Magnesium Metabolism', 'author': 'Peacock M.', 'year': '1976'} / Calcium, Phosphate and Magnesium Metabolism by Peacock M. (1976)
10.1042/cs0610477
10.1016/0002-9343(62)90183-3
10.1136/bmj.1.6163.589
10.1016/S0140-6736(77)92280-2
10.1016/S0140-6736(77)92553-3
10.1016/S0140-6736(80)90283-4
{'key': 'e_1_2_1_28_2', 'first-page': '212', 'article-title': 'Formation of vitamin D metabolites following correction of human vitamin D deficiency. Observations in patients with nutritional osteomalacia', 'volume': '5', 'author': 'Stanbury SW', 'year': '1981', 'journal-title': 'Min Electr Metab'} / Min Electr Metab / Formation of vitamin D metabolites following correction of human vitamin D deficiency. Observations in patients with nutritional osteomalacia by Stanbury SW (1981)
FrancisRM PeacockM TaylorGA StorerJH NordinBEC.Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites in the bowel.Clin Sci in press.
10.1016/S0300-595X(80)80026-0

Dates

Type	When
Created	17 years, 5 months ago (March 20, 2008, 9:14 a.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 5:59 a.m.)
Indexed	1 year, 2 months ago (June 22, 2024, 2:45 a.m.)
Issued	41 years, 11 months ago (Oct. 1, 1983)
Published	41 years, 11 months ago (Oct. 1, 1983)
Published Online	17 years, 5 months ago (March 20, 2008)
Published Print	41 years, 11 months ago (Oct. 1, 1983)

Funders 0

None

BibTeX

@article{FRANCIS_1983, title={Calcium malabsorption in the elderly: the effect of treatment with oral 25‐hydroxyvitamin D3}, volume={13}, ISSN={1365-2362}, url={http://dx.doi.org/10.1111/j.1365-2362.1983.tb00119.x}, DOI={10.1111/j.1365-2362.1983.tb00119.x}, number={5}, journal={European Journal of Clinical Investigation}, publisher={Wiley}, author={FRANCIS, R. M. and PEACOCK, M. and STORER, J. H. and DAVIES, A. E. J. and BROWN, W. B. and NORDIN, B. E. C.}, year={1983}, month=oct, pages={391–396} }

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