DOI: 10.1111/j.1365-2362.1979.tb01667.x. Esterification of cholesterol in human small intestine: the importance of acyl‐CoA:cholesterol acyltransferase

Esterification of cholesterol in human small intestine: the importance of acyl‐CoA:cholesterol acyltransferase

10.1111/j.1365-2362.1979.tb01667.x

Crossref journal-article

Wiley

European Journal of Clinical Investigation (311)

Abstract

Abstract. Human intestinal mucosa contains acyl‐CoA: cholesterol acyltransferase activity. The enzyme has been studied by using oleylcarnitine, CoA and carnitine palmitoyltransferase as an oleyl‐CoA regenerating system. The enzyme was found in the particulate fraction of the cells, it had a pH optimum between 7.2 and 8.2, and was inhibited by taurocholate. The specific enzymic activity in biopsies from intestinal mucosa of normal men was found to be 3.6 ± 1.37 nmol cholesteryl ester formed mg protein‐1 h‐1, an activity which can account for all cholesteryl esters in intestinal lymph. Low enzymic activity was found in biopsies from patients with small intestinal disorders. Two pancreatectomized patients had values within the normal range.

Bibliography

NORUM, K. R., LILLJEQVIST, A., HELGERUD, P., NORMANN, E. R., MO, A., & SELBEKK, B. (1979). Esterification of cholesterol in human small intestine: the importance of acylâCoA:cholesterol acyltransferase. European Journal of Clinical Investigation, 9(1), 55â62. Portico.

Authors 6

KAARE R. NORUM (first)
ANNE‐CHARLOTTE LILLJEQVIST (additional)
PER HELGERUD (additional)
ELDAR R. NORMANN (additional)
ARVE MO (additional)
BODIL SELBEKK (additional)

References 26 Referenced 65

10.1093/ajcn/26.6.647
10.1016/S0022-2275(20)41706-7
10.1152/physrev.1965.45.4.747
10.1016/S0022-2275(20)41678-5 / J Lipid Res / The lecithin:cholesterol acyl transferase activity of rat intestinal lymph by Bennett Clark S. (1977)
{'key': 'e_1_2_1_6_2', 'first-page': '1407', 'volume-title': 'Handbook of Physiology', 'author': 'Treadwell C.R.', 'year': '1968'} / Handbook of Physiology by Treadwell C.R. (1968)
10.1080/00365521.1976.12097161 / Scand J Gastroent / Coenzyme‐A‐dependent esterification of cholesterol in rat intestinal mucosa by Haugen R. (1976)
10.3109/00365527709180929
10.1159/000175588
{'key': 'e_1_2_1_10_2', 'first-page': '95', 'article-title': 'Palmitoyl‐CoA:carnitine palmitoyltransferase. Purification from calf‐liver mitochondria and some properties of the enzyme', 'volume': '89', 'author': 'Norum K.R.', 'year': '1964', 'journal-title': 'Biochim Biophys Acta'} / Biochim Biophys Acta / Palmitoyl‐CoA:carnitine palmitoyltransferase. Purification from calf‐liver mitochondria and some properties of the enzyme by Norum K.R. (1964)
{'key': 'e_1_2_1_11_2', 'first-page': '64', 'volume-title': 'Gastroenterologisk undersøkelsesmetodikk', 'author': 'Gjone E.', 'year': '1970'} / Gastroenterologisk undersøkelsesmetodikk by Gjone E. (1970)
10.1016/S0021-9258(19)52451-6
10.3109/00365517109080184
10.1152/ajplegacy.1955.181.3.523
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10.1016/S0021-9258(18)96064-3 / J Biol Chem / The effects of detergents on palmitoyl coenzyme A:carnitine palmitoyltransferase by Bremer J. (1967)
NorumK.R.&LilljeqvistA‐C.(1978)Unpublished observations.
10.1016/0021-9150(74)90076-8
10.1016/S0021-9258(18)91319-0
10.1016/0005-2760(70)90082-2
10.3181/00379727-113-28481
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10.1016/S0021-9258(19)41498-1 / J Biol Chem / Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols by Brown M.S. (1975)
10.1161/01.RES.35.5.692
10.1016/0021-9150(77)90071-5
10.1016/S0022-2275(20)41590-1 / J Lipid Res / 3‐Hydroxy‐3‐methylglytaryl coenzyme A reductase in isolated villous and crypt cells of the rat ileum by Merchant J.L. (1977)
10.1172/JCI105267

Dates

Type	When
Created	17 years, 5 months ago (March 20, 2008, 9:50 a.m.)
Deposited	1 year, 9 months ago (Nov. 10, 2023, 7:58 p.m.)
Indexed	2 days, 21 hours ago (Sept. 4, 2025, 10:34 a.m.)
Issued	46 years, 7 months ago (Feb. 1, 1979)
Published	46 years, 7 months ago (Feb. 1, 1979)
Published Online	17 years, 5 months ago (March 20, 2008)
Published Print	46 years, 7 months ago (Feb. 1, 1979)

Funders 0

None

BibTeX

@article{NORUM_1979, title={Esterification of cholesterol in human small intestine: the importance of acyl‐CoA:cholesterol acyltransferase}, volume={9}, ISSN={1365-2362}, url={http://dx.doi.org/10.1111/j.1365-2362.1979.tb01667.x}, DOI={10.1111/j.1365-2362.1979.tb01667.x}, number={1}, journal={European Journal of Clinical Investigation}, publisher={Wiley}, author={NORUM, KAARE R. and LILLJEQVIST, ANNE‐CHARLOTTE and HELGERUD, PER and NORMANN, ELDAR R. and MO, ARVE and SELBEKK, BODIL}, year={1979}, month=feb, pages={55–62} }

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