DOI: 10.1111/j.1365-2265.1976.tb03835.x. STRUCTURE ACTIVITY STUDIES ON SOMATOSTATIN

STRUCTURE ACTIVITY STUDIES ON SOMATOSTATIN

10.1111/j.1365-2265.1976.tb03835.x

Crossref journal-article

Wiley

Clinical Endocrinology (311)

Abstract

SUMMARYSeven synthetic analogues of somatostatin helped clarify structural requirements for suppression of growth hormone secretion in rats. Size of the ring is not critical; deletions of serine‐13, lysine‐4 or asparagine‐5 result in peptides which retain an appreciable fraction of the activity. The analogue des‐Ala1, Gly2, Asn5‐somatostatin lowers plasma growth hormone and insulin levels without affecting plasma glucagon levels significantly.

Bibliography

SARANTAKIS, D., McKINLEY, W. A., JAUNAKAIS, I., CLARK, D., & GRANT, N. H. (1976). STRUCTURE ACTIVITY STUDIES ON SOMATOSTATIN. Clinical Endocrinology, 5(s1). Portico.

Authors 5

D. SARANTAKIS (first)
W. A. McKINLEY (additional)
I. JAUNAKAIS (additional)
D. CLARK (additional)
N. H. GRANT (additional)

References 12 Referenced 30

10.1016/S0140-6736(73)92873-0
10.1016/S0140-6736(74)92071-6
10.1016/S0140-6736(74)90869-1
10.1126/science.179.4068.77
10.1210/jcem-38-5-913
10.1126/science.1089999
10.1056/NEJM197409122911102
10.1210/endo-96-3-749
10.1002/hlca.19730560503
10.1021/ja00897a025
10.1016/0006-291X(73)90913-3
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Dates

Type	When
Created	17 years, 5 months ago (March 18, 2008, 8:13 a.m.)
Deposited	1 year, 11 months ago (Sept. 26, 2023, 6:55 a.m.)
Indexed	1 year, 7 months ago (Jan. 15, 2024, 5:43 a.m.)
Issued	49 years, 7 months ago (Feb. 1, 1976)
Published	49 years, 7 months ago (Feb. 1, 1976)
Published Online	17 years, 5 months ago (March 18, 2008)
Published Print	49 years, 7 months ago (Feb. 1, 1976)

Funders 0

None

BibTeX

@article{SARANTAKIS_1976, title={STRUCTURE ACTIVITY STUDIES ON SOMATOSTATIN}, volume={5}, ISSN={1365-2265}, url={http://dx.doi.org/10.1111/j.1365-2265.1976.tb03835.x}, DOI={10.1111/j.1365-2265.1976.tb03835.x}, number={s1}, journal={Clinical Endocrinology}, publisher={Wiley}, author={SARANTAKIS, D. and McKINLEY, W. A. and JAUNAKAIS, I. and CLARK, D. and GRANT, N. H.}, year={1976}, month=feb }

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