Abstract
SummaryThe collectins are a group of soluble multimeric lectins, which contain collagenous segments, and resemble the complement protein Clq in aspects of their structures and functions. This group of proteins, which includes MBP, SP-A, SP-D, conglutinin and CL-43, are known to act as opsonins in various circumstances, and are likely to have roles in innate immunity. The focus of current research is to pursue the hypothesis that the collectins recognize and bind to non-host carbohydrate structures on microorganisms and particles, and participate in the processing or elimination of such material, either by direct interaction with phagocytic cell receptors, or by indirect routes such as complement activation.
References
41
Referenced
21
10.1016/0014-5793(89)80689-1
/ FEBS Lett / Structures and functions of the group of mammalian lectins containing collagen-like sequences by Thiel (1989){'key': '2022011615004948400_b2', 'first-page': '188', 'article-title': 'Interaction of lung surfactant protein A with Clq-receptor', 'volume': '8', 'author': 'Malhotra', 'year': '1991', 'journal-title': 'Complement Inflamm.'}
/ Complement Inflamm. / Interaction of lung surfactant protein A with Clq-receptor by Malhotra (1991)10.1002/eji.1830220616
/ Eur. J. Immunol. / Interaction of Clq-receptor (ClqR) with lung surfactant protein A (SP-A) by Malhotra (1992)10.1016/0167-5699(94)90136-8
/ Immunology Today / Collections: collagenous C-type lectins of the innate immune defence system by Holmskov (1994){'key': '2022011615004948400_b5', 'first-page': '224', 'article-title': 'Structure and function of collections: humoral C-type lectins with collagenous regions', 'volume': '93', 'author': 'Holmskov', 'year': '1993', 'journal-title': 'Behring Inst Mitt'}
/ Behring Inst Mitt / Structure and function of collections: humoral C-type lectins with collagenous regions by Holmskov (1993){'key': '2022011615004948400_b6', 'first-page': '6', 'article-title': 'Similarity in structure between Clq and the collections as judged by electron microscopy', 'volume': '93', 'author': 'Lu', 'year': '1993', 'journal-title': 'Behring Inst Mitt'}
/ Behring Inst Mitt / Similarity in structure between Clq and the collections as judged by electron microscopy by Lu (1993){'key': '2022011615004948400_b7', 'volume-title': 'New Aspects of Complement Structure and Function', 'author': 'Lu', 'year': '1994'}
/ New Aspects of Complement Structure and Function by Lu (1994)10.1016/0167-5699(91)90004-D
/ Immunol. Today / Cl: Molecular Interaction with Activating Systems by Sim (1991)10.1042/bst0220106
/ Biochem Soc Trans / Interactions of carbohydrates and lectins with complement by Sim (1994){'key': '2022011615004948400_b10', 'first-page': '6', 'article-title': 'Similirity in structure between Clq and the collections as judged by electron microscopy', 'volume': '93', 'author': 'Lu', 'year': '1993', 'journal-title': 'Behring Inst Mitt'}
/ Behring Inst Mitt / Similirity in structure between Clq and the collections as judged by electron microscopy by Lu (1993)10.1038/360127a0
/ Nature / Structure of a C-type marmoset-binding protein complexed with an oligosaccharide by Weis (1992)10.1016/0952-7915(93)90082-4
/ Curr Opin Immunol / Collectins: pattern recognition molecules involved in first line hos t defence by Sastry (1993){'key': '2022011615004948400_b13', 'article-title': 'Interaction of human collections with influenza virus', 'author': 'Malhotra', 'journal-title': 'Biochem J'}
/ Biochem J / Interaction of human collections with influenza virus by Malhotra{'key': '2022011615004948400_b14', 'article-title': 'Structural and functional properties of the bovine plasma C-type lectin CL-43', 'author': 'Holmskov', 'year': '1994', 'journal-title': 'J Biol Chem'}
/ J Biol Chem / Structural and functional properties of the bovine plasma C-type lectin CL-43 by Holmskov (1994)10.1016/0022-2836(88)90448-2
/ J Mol Biol / Macromolecular organisation of natural and recombinant lung surfactant protein SP 28–36 by Voss (1988)10.1042/bj2930015
/ Biochem J / Localization of the receptor-binding site in the collectin family of proteins by Malhotra (1993)10.1016/S0021-9258(18)47587-4
/ J Biol Chem / Serum lectin with known structure activates complement through the classical pathway by Ikeda (1987)10.4049/jimmunol.144.6.2287
/ J Immunol / Binding of the pentamer/ hexamer forms of mannan-binding protein to zymosan activates the proenzyme Clr2Cls2 complex, of the classical pathway of complement, without involvement of Clq by Lu (1990)10.1016/S0021-9258(19)39928-4
/ J Biol Chem / The mechanism of carbohydrate-mediated complement activation by the serum mannan-binding protein by Ohta (1990)10.4049/jimmunol.128.3.1256
/ J Immunol / A new complement-dependent bactericidal factor found in nonimmune mouse sera: specific binding to polysaccharide of Ra chemotype Salmonella by Ihara (1982)10.4049/jimmunol.141.12.4271
/ J Immunol / The C4 and C2 but not Cl components of complement are responsible for the complement activation triggered by the Ra-reactive factor by Ji (1988)10.1016/0006-291X(92)90531-O
/ Biochem Biophys Res Commun / Human mannose-binding protein is identical to a component of Ra-reactive factor by Matsushita (1992)10.1084/jem.176.6.1497
/ J Exp Med / Activation of the classical complement pathway by mannose-binding protein in association with a novel Cls-like serine protease by Matsushita (1992)10.1006/bbrc.1993.2349
/ Biochem Biophys Res Commun / A new member of the Cls family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum by Takada (1993)10.4049/jimmunol.152.5.2308
/ J Immunol / A 100kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organisation similar to Clr and Cls by Takayama (1994){'key': '2022011615004948400_b26', 'article-title': 'Mechanism of complement activation mediated by Mannan-Binding Protein', 'author': 'Lu', 'year': '1994', 'journal-title': 'Immunology'}
/ Immunology / Mechanism of complement activation mediated by Mannan-Binding Protein by Lu (1994)10.1084/jem.172.3.955
/ J Exp Med / Human leukocyte Clq receptor binds other soluble proteins with collagen domains by Malhotra (1990){'key': '2022011615004948400_b28', 'first-page': '300', 'article-title': 'Surfactant protein D binding to alveolar macrophages', 'author': 'Miyamura', 'year': '1994', 'journal-title': 'Biochem J'}
/ Biochem J / Surfactant protein D binding to alveolar macrophages by Miyamura (1994){'key': '2022011615004948400_b29', 'first-page': '20345', 'article-title': 'Phagocytic cell m olecu les that bind the collagen-like region of Cl q- involvement in Clq-mediated phagocytosis', 'volume': '266', 'author': 'Guan', 'year': '1991', 'journal-title': 'J Biol Chem 1991'}
/ J Biol Chem 1991 / Phagocytic cell m olecu les that bind the collagen-like region of Cl q- involvement in Clq-mediated phagocytosis by Guan (1991)10.1042/bj2620625
/ Biochem J / Chemical and hydrodynamic characterization of the human leukocyte receptor for complement subcomponent Cl q by Malhotra (1989){'key': '2022011615004948400_b31', 'first-page': '341', 'article-title': 'Structure and homology of human Clq receptor (collectin receptor)', 'volume': '78', 'author': 'Malhotra', 'year': '1993', 'journal-title': 'Immunology'}
/ Immunology / Structure and homology of human Clq receptor (collectin receptor) by Malhotra (1993){'key': '2022011615004948400_b32', 'first-page': '254', 'article-title': 'Collectin receptor (Clq receptor): structure and function', 'volume': '93', 'author': 'Malhotra', 'year': '1993', 'journal-title': 'Behring Inst Mitt'}
/ Behring Inst Mitt / Collectin receptor (Clq receptor): structure and function by Malhotra (1993){'key': '2022011615004948400_b33', 'first-page': '236', 'article-title': 'The Clq-R participates in immunoregulation and signal transduction', 'volume': '93', 'author': 'Ghebrehiwet', 'year': '1993', 'journal-title': 'Behring Inst Mitt'}
/ Behring Inst Mitt / The Clq-R participates in immunoregulation and signal transduction by Ghebrehiwet (1993){'key': '2022011615004948400_b34', 'first-page': '241', 'article-title': 'Functional aspects of the Clq receptors', 'volume': '93', 'author': 'Tenner', 'year': '1993', 'journal-title': 'Behring Inst Mitt'}
/ Behring Inst Mitt / Functional aspects of the Clq receptors by Tenner (1993)10.1084/jem.160.5.1375
/ J Exp Med / Identification of the Raji cell membrane-derived Clq inhibitor as a receptor for human Clq, Purification and immunochemical characterization by Ghebrehiwet (1984){'key': '2022011615004948400_b36', 'first-page': '493', 'article-title': 'Characterization of Clq-binding material released from the membranes of Raji and U937 cells by limited proteolysis with trypsin', 'volume': '255', 'author': 'Erdei', 'year': '1988', 'journal-title': 'Biochem J'}
/ Biochem J / Characterization of Clq-binding material released from the membranes of Raji and U937 cells by limited proteolysis with trypsin by Erdei (1988)10.1172/JCI114582
/ J Clin Invest / Molecular cloning, expression, and chromosome 19 localization of a human Ro/ SSA autoantigen by McCauliffe (1990)10.4049/jimmunol.147.9.3031
/ J Immun on / Characterization of the autoantigen cal reticulin by Rokeach (1991)10.1111/j.1365-2249.1993.tb08213.x
/ Clin Exp Immunol / A calreticulin-like protein co-purifies with a ‘60kD’ component of Ro/SSA, but is not recognized by antibodies in Sjogren's syndrome sera by Lu (1993)10.4049/jimmunol.151.10.5800
/ J Immunol / Autoimmunity and filariasis. Autoantibodies against cytoplasmic cellular proteins in sera of patients with onchocerciasis by Meilof (1993)10.1016/0140-6736(91)93263-9
/ Lancet / Molecular basis of op-sonic defect in immunodeficient children by Sumiya (1991)
Dates
Type | When |
---|---|
Created | 15 years, 1 month ago (July 26, 2010, 5:19 p.m.) |
Deposited | 2 years, 3 months ago (June 2, 2023, 5:58 a.m.) |
Indexed | 4 months, 3 weeks ago (April 15, 2025, 7:33 a.m.) |
Issued | 31 years, 1 month ago (Aug. 1, 1994) |
Published | 31 years, 1 month ago (Aug. 1, 1994) |
Published Online | 17 years, 2 months ago (June 28, 2008) |
Published Print | 17 years, 2 months ago (June 28, 2008) |
@article{MALHOTRA_1994, title={Collectins, collectin receptors and the lectin pathway of complement activation}, volume={97}, ISSN={1365-2249}, url={http://dx.doi.org/10.1111/j.1365-2249.1994.tb06254.x}, DOI={10.1111/j.1365-2249.1994.tb06254.x}, number={Supplement_2}, journal={Clinical and Experimental Immunology}, publisher={Oxford University Press (OUP)}, author={MALHOTRA, R and LU, J and HOLMSKOV, U and SIM, R B}, year={1994}, month=aug, pages={4–9} }