DOI: 10.1111/j.1365-2222.1986.tb01950.x. Pneumococcus‐specific immunoglobulin E in cigarette smokers

Pneumococcus‐specific immunoglobulin E in cigarette smokers

10.1111/j.1365-2222.1986.tb01950.x

Crossref journal-article

Wiley

Clinical & Experimental Allergy (311)

Abstract

SummaryA relationship between elevated scrum immunoglobulin E levels and smoking has been demonstrated in epidemiological studies. Allergy skin test data suggest that the excess immunoglobulin E of smokers is not specific for aeroallergens. It is possible that the excess immunoglobulin E is specific for microorganisms that often infect the lower respiratory tract of smokers. To investigate this possibility we utilized a radio‐allergosorbent test assay for detecting serum immunoglobulin E specific for Streptococcus pneumoniae, an organism commonly isolated from the respiratory tract of smokers with chronic bronchitis. We assayed sera of thirty smokers and thirty nonsmokers for immunoglobulin E specific for Streptococcus pneumoniae. Individual sera were considered positive for pneumococcus‐specific immunoglobulin E if the binding was at least twice the non‐specific binding at the total immunoglobulin E concentration of the particular serum. Eleven of the thirty sera of smokers and two of the thirty nonsmokers were positive for pneumococcus‐specific immunoglobulin E. By chi‐square analysis of these data, the prevalence of pneumococcus‐specific immunoglobulin E was significantly greater in the smoking group compared with the non‐smoking group (P<0·02). These results suggest that the excess immunoglobulin E of smokers is, at least in part, specific for microorganisms that infect the airways.

Bibliography

BLOOM, J. W., HALONEN, M., DUNN, A. M., PINNAS, J. L., & BURROWS, B. (1986). Pneumococcusâspecific immunoglobulin E in cigarette smokers. Clinical & Experimental Allergy, 16(1), 25â32. Portico.

Authors 5

J. W. BLOOM (first)
MARILYN HALONEN (additional)
ANITA M. DUNN (additional)
J. L. PINNAS (additional)
B. BURROWS (additional)

References 18 Referenced 18

{'key': 'e_1_2_1_2_2', 'first-page': '523', 'article-title': 'The relationship of serum immunoglobulin E to cigarette smoking', 'volume': '124', 'author': 'Burrows B', 'year': '1981', 'journal-title': 'Am Rev Respir Dis'} / Am Rev Respir Dis / The relationship of serum immunoglobulin E to cigarette smoking by Burrows B (1981)
10.1016/0091-6749(82)90148-8
{'key': 'e_1_2_1_4_2', 'first-page': '262', 'article-title': 'Immunoglobulin levels in smokers and nonsmokers', 'volume': '44', 'author': 'Gerrard JW', 'year': '1980', 'journal-title': 'Ann Allergy'} / Ann Allergy / Immunoglobulin levels in smokers and nonsmokers by Gerrard JW (1980)
10.1016/S0272-5231(21)00103-9
10.1093/oxfordjournals.aje.a112141
10.1016/0091-6749(81)90167-6
10.7326/0003-4819-84-2-129
10.4049/jimmunol.125.6.2437 / J Immunol / IgE antibodies to Staphylococcus aureus and Candida alhicans in patients with the syndrome of hyper‐immunoglobulin E and recurrent infections by Berger M (1980)
{'key': 'e_1_2_1_10_2', 'first-page': '84', 'volume-title': 'Methods in Immunology', 'author': 'Garvey J', 'year': '1977'} / Methods in Immunology by Garvey J (1977)
10.1016/0091-6749(82)90042-2
10.1016/0091-6749(78)90138-0
{'key': 'e_1_2_1_13_2', 'first-page': '995', 'article-title': 'Immunochemical and physicochemical properties of tobacco extracts', 'volume': '120', 'author': 'Gleich GJ', 'year': '1979', 'journal-title': 'Am Rev Respir Dis'} / Am Rev Respir Dis / Immunochemical and physicochemical properties of tobacco extracts by Gleich GJ (1979)
{'key': 'e_1_2_1_14_2', 'first-page': '168', 'article-title': 'IgE antibody response of smokers, nonsmokers, and ‘smoke‐sensitive’ persons to tobacco leaf and smoke antigens', 'volume': '121', 'author': 'Lehrer SB', 'year': '1980', 'journal-title': 'Am Rev Respir Dis'} / Am Rev Respir Dis / IgE antibody response of smokers, nonsmokers, and ‘smoke‐sensitive’ persons to tobacco leaf and smoke antigens by Lehrer SB (1980)
10.1056/NEJM197904123001506
10.1128/iai.32.2.967-968.1981 / Infec Immunol / Specific pseudomonas immunoglobulin E antibodies in sera of patients with cystic fibrosis by Shen J (1981)
10.1111/j.1398-9995.1980.tb02019.x
10.1111/j.1365-2222.1982.tb01642.x
10.1378/chest.84.6.657

Dates

Type	When
Created	19 years, 4 months ago (April 28, 2006, 8:53 a.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 9:30 a.m.)
Indexed	1 year, 10 months ago (Oct. 25, 2023, 8:58 p.m.)
Issued	39 years, 8 months ago (Jan. 1, 1986)
Published	39 years, 8 months ago (Jan. 1, 1986)
Published Online	19 years, 4 months ago (April 27, 2006)
Published Print	39 years, 8 months ago (Jan. 1, 1986)

Funders 0

None

BibTeX

@article{BLOOM_1986, title={Pneumococcus‐specific immunoglobulin E in cigarette smokers}, volume={16}, ISSN={1365-2222}, url={http://dx.doi.org/10.1111/j.1365-2222.1986.tb01950.x}, DOI={10.1111/j.1365-2222.1986.tb01950.x}, number={1}, journal={Clinical & Experimental Allergy}, publisher={Wiley}, author={BLOOM, J. W. and HALONEN, MARILYN and DUNN, ANITA M. and PINNAS, J. L. and BURROWS, B.}, year={1986}, month=jan, pages={25–32} }

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