DOI: 10.1111/j.1365-2141.1989.tb07680.x. 18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance

18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance

10.1111/j.1365-2141.1989.tb07680.x

Crossref journal-article

Wiley

British Journal of Haematology (311)

Abstract

Summary. Cytogenetic, molecular genetic and clinical information was collected for 102 cases of diffuse large cell lymphoma (DLCL) ascertained in a diagnostic laboratory over a 3‐year period. Nineteen cases showed evidence of either a t(14;18) or a rearrangement of one of three genomic probes for breakpoints at 18q21. Clinical and histologic evidence of transformation from follicular lymphoma or chronic lymphocytic leukaemia was available in six cases. Except for age, prognostic clinical variables (LDH, stage, extranodal involvement) were similar between the 18q21 rearranged patients and DLCL patients without 18q21 rearrangement. At a median follow‐up in excess of 2 years for both groups, there was no difference in overall survival between the 18q21 rearranged group compared to DLCL patients lacking this genetic abnormality. The median disease‐free survival for the 18q21 rearranged group, however, was significantly shorter and survival in partial remission longer. The propensity for extended survival of the 18q21 rearranged DLCL patients with residual or recurrent disease resembled the clinical behaviour of nodular lymphoma patients with t(14;18). These results suggest that cytogenic or molecular genetic identification of a chromosome 18q21 translocation may be of prognostic significance in the analysis of treatment protocols for patients with DLCL.

Bibliography

Offit, K., Koduru, P. R. K., Hollis, R., Filippa, D., Jhanwar, S. C., Clarkson, B. C., & Chaganti, R. S. K. (1989). 18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance. British Journal of Haematology, 72(2), 178â183. Portico.

Authors 7

Kenneth Offit (first)
Prasad R. K. Koduru (additional)
Rachel Hollis (additional)
Daniel Filippa (additional)
Suresh C. Jhanwar (additional)
Bayard C. Clarkson (additional)
R. S. K. Chaganti (additional)

References 24 Referenced 69

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{'key': 'e_1_2_1_8_1', 'first-page': '5372', 'article-title': 'Predictive model for prognosis in advanced diffuse histiocytic lymphoma', 'volume': '46', 'author': 'Danieu L.', 'year': '1986', 'journal-title': 'Cancer Research'} / Cancer Research / Predictive model for prognosis in advanced diffuse histiocytic lymphoma by Danieu L. (1986)
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{'key': 'e_1_2_1_17_1', 'first-page': '794', 'article-title': "MACOP‐B for advanced diffuse intermediate and high grade non‐Hodgkin's lymphoma: preliminary results of the Memorial experience", 'volume': '6', 'author': 'Lowenthal D.A.', 'year': '1987', 'journal-title': 'Proceedings of the American Society of Clinical Oncology'} / Proceedings of the American Society of Clinical Oncology / MACOP‐B for advanced diffuse intermediate and high grade non‐Hodgkin's lymphoma: preliminary results of the Memorial experience by Lowenthal D.A. (1987)
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10.1056/NEJM198711053171904
10.1056/NEJM198701083160204

Dates

Type	When
Created	17 years, 5 months ago (March 12, 2008, 10:11 a.m.)
Deposited	1 year, 11 months ago (Sept. 26, 2023, 6:16 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 2, 2025, 12:57 a.m.)
Issued	36 years, 2 months ago (June 1, 1989)
Published	36 years, 2 months ago (June 1, 1989)
Published Online	17 years, 5 months ago (March 12, 2008)
Published Print	36 years, 2 months ago (June 1, 1989)

Funders 0

None

BibTeX

@article{Offit_1989, title={18q21 rearrangement in diffuse large cell lymphoma: incidence and clinical significance}, volume={72}, ISSN={1365-2141}, url={http://dx.doi.org/10.1111/j.1365-2141.1989.tb07680.x}, DOI={10.1111/j.1365-2141.1989.tb07680.x}, number={2}, journal={British Journal of Haematology}, publisher={Wiley}, author={Offit, Kenneth and Koduru, Prasad R. K. and Hollis, Rachel and Filippa, Daniel and Jhanwar, Suresh C. and Clarkson, Bayard C. and Chaganti, R. S. K.}, year={1989}, month=jun, pages={178–183} }

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  "abstract": "<jats:p><jats:bold>Summary. </jats:bold> Cytogenetic, molecular genetic and clinical information was collected for 102 cases of diffuse large cell lymphoma (DLCL) ascertained in a diagnostic laboratory over a 3\u2010year period. Nineteen cases showed evidence of either a t(14;18) or a rearrangement of one of three genomic probes for breakpoints at 18q21. Clinical and histologic evidence of transformation from follicular lymphoma or chronic lymphocytic leukaemia was available in six cases. Except for age, prognostic clinical variables (LDH, stage, extranodal involvement) were similar between the 18q21 rearranged patients and DLCL patients without 18q21 rearrangement. At a median follow\u2010up in excess of 2 years for both groups, there was no difference in overall survival between the 18q21 rearranged group compared to DLCL patients lacking this genetic abnormality. The median disease\u2010free survival for the 18q21 rearranged group, however, was significantly shorter and survival in partial remission longer. The propensity for extended survival of the 18q21 rearranged DLCL patients with residual or recurrent disease resembled the clinical behaviour of nodular lymphoma patients with t(14;18). These results suggest that cytogenic or molecular genetic identification of a chromosome 18q21 translocation may be of prognostic significance in the analysis of treatment protocols for patients with DLCL.</jats:p>",
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