DOI: 10.1111/j.1365-2141.1989.tb00220.x. Vitamin D metabolism in myeloma

10.1111/j.1365-2141.1989.tb00220.x

Crossref journal-article

Wiley

British Journal of Haematology (311)

Abstract

Summary. We measured serum concentrations of vitamin D metabolites in 27 patients with myeloma, 16 of whom were hypercalcaemic. Serum values were compared with values from normal controls. Serum concentrations of calcitriol (1,25‐dihydroxyvitamin D; 1,25(OH)2D3) were decreased in both hyper‐ and normocalcaemic patients, but more markedly so in hypercalcaemia. These findings were not solely due to impaired renal function nor due to an inadequate supply of 25‐hydroxyvitamin D, and in hypercalcaemic patients were reversed by diphosphonate treatment. We conclude that hypercalcaemia in myeloma is not mediated by abnormalities in vitamin D metabolism. Decreased serum concentrations of 1,25(OH)2D3 may adversely affect both skeletal and tumour metabolism.

Bibliography

LawsonâMatthew, P., Clayton, J., GuillandâCumming, D., Yates, A., Preston, E., Greaves, M., & Kanis, J. A. (1989). Vitamin D metabolism in myeloma. British Journal of Haematology, 73(1), 57â60. Portico.

Authors 7

Peter Lawson‐Matthew (first)
Jill Clayton (additional)
Diane Guilland‐Cumming (additional)
Ashley Yates (additional)
Eric Preston (additional)
Michael Greaves (additional)
John A. Kanis (additional)

References 21 Referenced 6

10.1002/1097-0142(197510)36:4<1192::AID-CNCR2820360403>3.0.CO;2-I
10.7326/0003-4819-100-1-1
10.1016/S0140-6736(78)92277-8
10.1016/0221-8747(82)90013-3
10.1111/j.1365-2141.1981.tb02758.x
{'key': 'e_1_2_1_7_1', 'first-page': '205', 'article-title': 'Vitamin D metabolites in patients with established non‐union of fracture', 'volume': '1', 'author': 'Haining S.A.', 'year': '1986', 'journal-title': 'Bone and Mineral'} / Bone and Mineral / Vitamin D metabolites in patients with established non‐union of fracture by Haining S.A. (1986)
10.1136/jcp.34.1.54
10.1073/pnas.80.1.201
{'key': 'e_1_2_1_10_1', 'first-page': '29', 'article-title': 'Multiple myeloma: review of 869 cases', 'volume': '50', 'author': 'Kyle R.A.', 'year': '1975', 'journal-title': 'Mayo Clinic Proceedings'} / Mayo Clinic Proceedings / Multiple myeloma: review of 869 cases by Kyle R.A. (1975)
10.1136/jcp.39.10.1143
10.7326/0003-4819-100-1-144
10.1056/NEJM197411142912001
10.1111/j.1365-2141.1983.tb02074.x
10.1126/science.6310748
{'key': 'e_1_2_1_16_1', 'first-page': '556', 'article-title': 'Circulating vitamin D metabolites and hypercalcaemia of malignancy', 'volume': '106', 'author': 'Ralston S.H.', 'year': '1984', 'journal-title': 'Acta Endocrinologica (Copenhagen)'} / Acta Endocrinologica (Copenhagen) / Circulating vitamin D metabolites and hypercalcaemia of malignancy by Ralston S.H. (1984)
10.1210/jcem-60-1-29
10.1172/JCI109902
10.1016/S0009-8981(84)80001-7
10.1056/NEJM198012113032401
{'key': 'e_1_2_1_21_1', 'first-page': '43', 'article-title': 'Treatment of hypercalcaemia of malignancy with intravenous clodronate', 'volume': '8', 'author': 'Urwin G.H.', 'year': '1987', 'journal-title': 'Bone'} / Bone / Treatment of hypercalcaemia of malignancy with intravenous clodronate by Urwin G.H. (1987)
10.1111/j.1365-2141.1982.tb03936.x

Dates

Type	When
Created	17 years, 5 months ago (March 12, 2008, 10:05 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 12:25 a.m.)
Indexed	1 year, 10 months ago (Oct. 23, 2023, 3:40 a.m.)
Issued	36 years ago (Sept. 1, 1989)
Published	36 years ago (Sept. 1, 1989)
Published Online	17 years, 2 months ago (July 7, 2008)
Published Print	36 years ago (Sept. 1, 1989)

Funders 0

None

BibTeX

@article{Lawson_Matthew_1989, title={Vitamin D metabolism in myeloma}, volume={73}, ISSN={1365-2141}, url={http://dx.doi.org/10.1111/j.1365-2141.1989.tb00220.x}, DOI={10.1111/j.1365-2141.1989.tb00220.x}, number={1}, journal={British Journal of Haematology}, publisher={Wiley}, author={Lawson‐Matthew, Peter and Clayton, Jill and Guilland‐Cumming, Diane and Yates, Ashley and Preston, Eric and Greaves, Michael and Kanis, John A.}, year={1989}, month=sep, pages={57–60} }

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