DOI: 10.1111/j.1365-2141.1987.tb02297.x. Erythroid and myeloid maturation patterns related to progenitor assessment in the myelodysplastic syndromes

Erythroid and myeloid maturation patterns related to progenitor assessment in the myelodysplastic syndromes

10.1111/j.1365-2141.1987.tb02297.x

Crossref journal-article

Wiley

British Journal of Haematology (311)

Abstract

Summary. Patterns of erythropoiesis and granulopoiesis were studied in 15 patients with myelodysplastic syndromes and in one with smouldering leukaemia by correlating CFU‐C, BFU‐E and CFU‐E cloning efficiency with erythroid and myeloid maturation indices derived from quantitative 14C‐autoradiography and with ferrokinetics. Maturation index of a cell lineage was defined as the ratio of cell production rate increase from the first to the last proliferative compartment over the corresponding normal value. The myeloid maturation index was reduced in all cases, but CFU‐C progenitor frequency was increased by a factor of 3. Erythroid maturation index was also reduced in most cases, and BFU‐E progenitor frequency was reduced by a factor of 2. Similarly, CFU‐E cloning efficiency corrected for the erythroid maturation index was 2.5–10‐fold lower than normal. Comparison of the erythroid maturation index with ferrokinetics revealed a constant ratio of ineffective erythropoiesis with a maturation disturbance in the proliferative pool twice that in the non‐proliferative pool.These findings indicate basic qualitative and quantitative abnormalities and a difference in the patterns of production of erythroid and myeloid cells in the myelodysplastic syndromes: Myeloid progenitors are increased in number but their maturation is grossly abnormal. On the other hand, the apparent reduction in erythroid progenitors and the reduced erythroid maturation index are attributable to both premature cell death of the more mature erythroblasts and an increased proerythroblast proliferation, i.e. extra divisions in the proerythroblast compartment at the expense of maturation.

Bibliography

DÃ¶rmer, P., Schalhorn, A., Wilmanns, W., & Hershko, C. (1987). Erythroid and myeloid maturation patterns related to progenitor assessment in the myelodysplastic syndromes. British Journal of Haematology, 67(1), 61â66. Portico.

Authors 4

P. Dörmer (first)
A. Schalhorn (additional)
W. Wilmanns (additional)
C. Hershko (additional)

References 28 Referenced 17

10.1159/000206682
10.1111/j.1365-2141.1982.tb02771.x
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10.1002/1097-0142(19830701)52:1<83::AID-CNCR2820520117>3.0.CO;2-9
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10.1016/0145-2126(79)90007-9

Dates

Type	When
Created	17 years, 5 months ago (March 12, 2008, 10:35 a.m.)
Deposited	1 year, 11 months ago (Sept. 27, 2023, 2:47 a.m.)
Indexed	1 year, 10 months ago (Oct. 29, 2023, 5:42 a.m.)
Issued	38 years ago (Sept. 1, 1987)
Published	38 years ago (Sept. 1, 1987)
Published Online	17 years, 2 months ago (July 7, 2008)
Published Print	38 years ago (Sept. 1, 1987)

Funders 0

None

BibTeX

@article{D_rmer_1987, title={Erythroid and myeloid maturation patterns related to progenitor assessment in the myelodysplastic syndromes}, volume={67}, ISSN={1365-2141}, url={http://dx.doi.org/10.1111/j.1365-2141.1987.tb02297.x}, DOI={10.1111/j.1365-2141.1987.tb02297.x}, number={1}, journal={British Journal of Haematology}, publisher={Wiley}, author={Dörmer, P. and Schalhorn, A. and Wilmanns, W. and Hershko, C.}, year={1987}, month=sep, pages={61–66} }

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  "abstract": "<jats:p><jats:bold>S<jats:sc>ummary</jats:sc>. </jats:bold> Patterns of erythropoiesis and granulopoiesis were studied in 15 patients with myelodysplastic syndromes and in one with smouldering leukaemia by correlating CFU\u2010C, BFU\u2010E and CFU\u2010E cloning efficiency with erythroid and myeloid maturation indices derived from quantitative <jats:sup>14</jats:sup>C\u2010autoradiography and with ferrokinetics. Maturation index of a cell lineage was defined as the ratio of cell production rate increase from the first to the last proliferative compartment over the corresponding normal value. The myeloid maturation index was reduced in all cases, but CFU\u2010C progenitor frequency was increased by a factor of 3. Erythroid maturation index was also reduced in most cases, and BFU\u2010E progenitor frequency was reduced by a factor of 2. Similarly, CFU\u2010E cloning efficiency corrected for the erythroid maturation index was 2.5\u201310\u2010fold lower than normal. Comparison of the erythroid maturation index with ferrokinetics revealed a constant ratio of ineffective erythropoiesis with a maturation disturbance in the proliferative pool twice that in the non\u2010proliferative pool.</jats:p><jats:p>These findings indicate basic qualitative and quantitative abnormalities and a difference in the patterns of production of erythroid and myeloid cells in the myelodysplastic syndromes: Myeloid progenitors are increased in number but their maturation is grossly abnormal. On the other hand, the apparent reduction in erythroid progenitors and the reduced erythroid maturation index are attributable to both premature cell death of the more mature erythroblasts and an increased proerythroblast proliferation, i.e. extra divisions in the proerythroblast compartment at the expense of maturation.</jats:p>",
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